Patho final exam

A child is born to a couple, one of whom is a carrier for a sex-linked recessive disease. The other parent has the disease ("having" the disease means the phenotype is seen—ie, S&S). What would be the chances that the couple has a child with the disease? (Use a Punnett square to figure this out.) In the question above, what are the chances that a child will be a carrier? a. 0% b. 25% c. 50% d. 75%

b. 25%

The parents of a new baby with Down's syndrome ask their nurse what to expect. She bases her answer on her understanding that the child will have a. developmental problems brought on by a sex-linked monosomy. b. developmental problems brought on by the pathologic interaction of 3 chromosomes where there should be only two. c. a phenotype based on defective mitochondrial protein synthesis that created aneuploidy. d. the phenotype of diminished IQ and physical differences that are caused by a single-gene disorder.

b. developmental problems brought on by the pathologic interaction of 3 chromosomes where there should be only two.

An 80-year-old patient is in shock from loss of blood following an accident. His vital signs are: BP 80/50 (normal ~ 120/80), HR 120 (norm = 60-100), RR 20 (norm = 12 to 20), T 98.6 (norm ~ 98.6). In assessing this patient, the nurse understands that the abnormal HR is a. probably the etiology for the patient's low BP. b. due to the patient's heart compensating for low blood volume by pumping faster. c. the normal compensatory response of shunting blood volume to the periphery. d. due to multiple risk factors.

b. due to the patient's heart compensating for low blood volume by pumping faster.

A family nurse practitioner (FNP) tells a patient that her biopsy shows leiomyosarcoma staged at T2N2M0. This patient has a a. benign tumor of the endometrium. b. smooth muscle malignancy that has spread to the lymph nodes. c. a malignancy of the uterus that has spread to distant sites. d. muscle cell tumor that is a carcinoma.

b. smooth muscle malignancy that has spread to the lymph nodes.

A patient who is having hyposecretion of ADH (antidiuretic hormone) would MOST LIKELY have the following sign: a. serum osmolality of 270. b. oliguria (low urine output). c. serum osmolality of 300. d. edema.

c. serum osmolality of 300.

A child accidentally ingests an insecticide with the ingredient cyanide. Knowing that cyanide suppresses the actions of cytochrome oxidase in the electron transport chain, what is a likely sign or symptom you would expect and why? (see page 2 of metabolic pathway concept map and use your critical thinking skills) a. Ketonuria due to increased glycogenesis. b. Confusion due to glycolysis. c. Mild euphoria due to enhanced production of ATP. d. Shortness of breath due to decreased ATP to use for the work of breathing.

d. Shortness of breath due to decreased ATP to use for the work of breathing.

All of the linkages below are correct EXCEPT a. cancer-related angiogenesis leaches nutrition from our cells cachexia, weakness. b. cancer injures prostate cells release into blood of high levels of a tumor marker called PSA (prostate-specific antigen) c. ingestion of foods high in preservatives increase genetic "hits" increased risk of cancer. d. age-related wear and tear of cells increased risk of cancerous lesions such as lipomas.

d. age-related wear and tear of cells increased risk of cancerous lesions such as lipomas.

Which sets of information are correctly linked? a. a patient with decreased RBC production: erythropoietin injections are needed to counteract overproliferation of red blood cells. b. arterial embolus blocks blood flow: decrease in venous circulation to tissue with resultant hypoxia of cells. c. gout: caused by diet high in urea. d. carbon monoxide: binds to Hgb in oxygen's place.

d. carbon monoxide: binds to Hgb in oxygen's place.

An RN is taking care of a cocaine addict who has just given birth to a baby with a teratogenic defect. A student nurse asks him what the probable etiology was. The RN shows understanding of genetic disorders when he says a. "It's hard to know the exact cause, but it's likely that fetal chromosomal development was impaired by the mom's intra-pregnancy cocaine ingestion." b. "The baby inherited a structural chromosomal defect that resulted in a problem called aneuploidy." c. "The baby inherited a gene that caused a defect called trisomy 21." d. "Since the little guy was born with the Philadelphia chromosome, he will be a life-long Phillies fan."

a. "It's hard to know the exact cause, but it's likely that fetal chromosomal development was impaired by the mom's intra-pregnancy cocaine ingestion."

A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype. What is the percent possibility of this couple's child having a completely normal genotype? a. 0% b. 25% c. 50% d. 100%

a. 0%

After not eating since breakfast 6 hours ago, a student taking a test notices a period of hunger and fatigue. He doesn't have access to food because he is taking the test. About 10 minutes later, though, he begins to feel ok again and finishes the test with flying colors. What has happened in his body? a. A compensatory response called glycogenolysis allowed him to access stored glucose for energy. b. A decompensatory response occurred, in which adrenalin increased and caused more blood flow to the brain. c. Since his blood sugar was likely low, the heart underwent a compensatory response known as hypertrophy in order to increase blood flow to central organs. d. Using a control mechanism known as hyperventilation, the student was able to "blow off" excess CO2 and thus have a clearer thinking process.

a. A compensatory response called glycogenolysis allowed him to access stored glucose for energy.

Link CML etiology with its S&S: a. Genes on a defective chromosome malfunction and code for extreme leukocytosis. b. Myelocytic leukocytes attack cells in the blood and cause changes known as The Philadelphia Story. c. A genetic defect causes cancerous changes in the blood vessels, producing hemangiosarcomas. d. Genes on an extra chromosome malfunction and cause defects in leukocyte development, resulting in leukopenia.

a. Genes on a defective chromosome malfunction and code for extreme leukocytosis.

The parents of a five year old girl complain anxiously to her pediatrician that in the last couple of weeks, no matter how much she eats, she keeps losing weight. She appears quite thin, well below her normal weight. Her blood sugar is 300 (normal range 70-99). She is diagnosed with Type I diabetes mellitus (DM 1). This girl's body needs to compensate for the acid/base imbalance noted above. Knowing that the lungs will compensate when the "metabolic" side is "sick" and the kidneys will compensate when the lungs are "sick," which compensatory response would you expect? a. Hyperventilation --increased respiratory rate (RR)-- to "blow off" CO2; this is the lungs' way to get rid of acids. b. Hypoventilation—decreased RR-- to "hold onto" CO2, since CO2 is an alkali that will counteract the acidosis. c. Kidneys will excrete more HCO3 into the urine to get rid of acidic byproducts. d. By hyperventilating and blowing off CO2, the body will bring the pH down to normal range.

a. Hyperventilation --increased respiratory rate (RR)-- to "blow off" CO2; this is the lungs' way to get rid of acids.

A large bookcase falls upon an elderly man in his home. His left leg is pinned and he cannot move for 2 days until his neighbor finds him. He is hospitalized with massive trauma to his left leg, with resultant rhabdomyolysis (rhabdomyo means striated muscle tissue; lysis means "break down"). His pulses in that foot are unpalpable and the foot is pale and cool. Eventually his foot must be amputated. Which mini-concept map, showing one event leading to the next, best fits with the scenario above? a. Massive mechanical trauma to leg distal arterial flow blocked ischemia to foot infarction of foot tissue amputation. b. Rhabdomyolysis damage to striated cells spreads to arteries proximal to the trauma ischemia infection amputation. c. Mechanical trauma interrupt cell membrane functions such as Na/K pump solute imbalance leg edema amputation. d. Cool foot tissues become too cold to conduct metabolic pathway functions cells become dormant distal arterial flow increases pathologically amputation.

a. Massive mechanical trauma to leg distal arterial flow blocked ischemia to foot infarction of foot tissue amputation.

A scene in the ER: A CIA operative who has had no previous medical history presents with initial complaints of nausea, vomiting, severe weakness. Now he is also short of breath. His pH is 7.20 and his HCO3 is 17. What is most likely going on in his body? a. Poisoning (by an enemy spy) cellular hypoxiacells must repeatedly go through anaerobic glycolysis to gain some ATPSincreases pyruvatelactic acidosis metabolic acidosis. b. Poisoning (by an enemy spy) hypoxiacells must continuously go through aerobic glycolysis instead of continuing down normal metabolic pathway low ATPSrespiratory acidosis. c. Gastrointestinal flu can't eat low blood sugarglucagon secretedtriggers glycogenolysis glucose released into blood, but also there are acidotic byproducts that must be countered by more HCO3increased alkalinitymetabolic alkalosis. d. Job stresslow oxygenation body compensates by increasing respiratory rate (hyperventilation) too much CO2 blown off respiratory alkalosis.

a. Poisoning (by an enemy spy) cellular hypoxiacells must repeatedly go through anaerobic glycolysis to gain some ATPSincreases pyruvatelactic acidosis metabolic acidosis.

A patient has advanced liver disease. Blood tests reveal that his serum albumin (albumin is one of the protein molecules found in the blood) level is very low. What eventually happens in this patient situation? a. Water would shift from blood (B) to tissue (T) because of decreased plasma oncotic pressure. b. There would be an increased intravascular volume due to increased plasma oncotic pressure. c. There would be dehydrated brain cells due to fluid shifting from T to B. d. Water would shift from T to B because of increased osmolality of the vascular space.

a. Water would shift from blood (B) to tissue (T) because of decreased plasma oncotic pressure.

A patient says she has read that free radicals might be partly responsible for the development of her disease process. She wants to know more information and if there is anything that can counteract free radicals. The nurse's explanation will be based on understanding that all of the following statements are true EXCEPT a. an example of a free radical is cytochrome oxide. b. free radical molecules initiate harmful reactions such as lipid peroxidation, which damages the lipids of cell membranes. c. the body's way to counteract free radicals include enzymes such as superoxide dismutase. d. free radicals are molecules that are in a highly reactive state and can be calmed by taking certain vitamins.

a. an example of a free radical is cytochrome oxide.

A 55 year old male is in the ER having a myocardial infarction (heart attack, AKA "M.I."), which is caused by coronary arteries that are clogged with fat and narrowed so that not enough oxygen-rich blood is getting to his heart. He admits that his daily nutrition is poor, consisting mainly of high-fat fast food. He has a family history of cardiac disease-- his father had a heart attack at age 46. The patient is obese and is a heavy cigarette smoker-- 2 PPD (packs per day). The patient said he had decided to take up jogging today and after a few minutes began having chest pain, nausea and shortness of breath. He went to the ER and was noted to have profuse diaphoresis (heavy sweating), tachycardia (rapid heart rate), and significant changes on his electrocardiogram (ECG or EKG). The patient recovers from this acute heart attack but his heart is so damaged that subsequently he has many episodes of congestive heart failure and many hospitalizations. A sequela of the MI was a. having to be hospitalized frequently because of problems associated with the damaged heart. b. having to be hospitalized frequently with repeat heart attacks. c. needing to jog more often. d. continuing to smoke 2 PPD.

a. having to be hospitalized frequently because of problems associated with the damaged heart.

In the previous question (A patient is hospitalized in renal failure. Because of her kidneys' inability to excrete water, she has generalized edema & a serum sodium of 129. Because the kidneys have also lost the ability to appropriately regulate potassium, she also has a serum potassium of 5.9.), the edema is most likely due to fluid shifting from the intravascular space into interstitial spaces secondary to all the following EXCEPT: a. hypertonicity of the plasma space. b. hypotonicity of the plasma space. c. hypoosmolality of the blood. d. diminished osmotic pressure of the blood.

a. hypertonicity of the plasma space.

Remember the patient in Assignment #1, with cancer who can't eat and has lost 80 pounds? Let's add to his assessment findings: let's say he has generalized edema and a serum protein of 4gm/dl (normal = 6.0 to 8.3 gm/dl ). Which is the most accurate mini-concept map linking his blood protein level with edema? a. hypoproteinemia concentration in blood is now lower than the normal concentration of fluids inside cells fluid goes from blood to tissue (B to T). b. hypoproteinemia concentration in blood is now higher than the normal concentration of fluids inside cells fluid goes from B to T c. hypoproteinemia blood is now hyperosmolar compared to the cells fluid goes from T to B d. hyperproteinemiablood now has lower oncotic pressure than normal fluid goes from T to B

a. hypoproteinemia concentration in blood is now lower than the normal concentration of fluids inside cells fluid goes from blood to tissue (B to T).

The phenotype of the person in question 27 (A person has hemophilia. Which is the correct genotype?) includes having ________ because __________. a. joint pain : the gene that codes for coagulation factors is defective, causing easy bleeding into the joints. b. joint pain : the joint tissue is oxygen-starved due to deformed hemoglobin in the RBCs. c. simian facial features : hemophilia is a teratogenic disorder caused by maternal alcohol abuse. d. severely shortened arms and legs : a drug called thalidomide caused the mutated genotype.

a. joint pain : the gene that codes for coagulation factors is defective, causing easy bleeding into the joints.

A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype. Mom's genotype is a. ss b. Ss c. SS d. none of the above.

a. ss

Re: the patient in the previous question (A patient who just came out of general anesthesia has lab work done. The serum osmo is 165. The nurse taking care of this patient suspects that the _____ is due to _________.): As an intervention to return the patient to normal serum osmolality, the nurse is likely to be ordered to hang an IV bag of _______ because once the fluid is distributed in the blood it will __________ and help return fluid compartment status to homeostasis. a. 0.45 NaCl: cause water to shift from tissue (T) to blood (B). b. 3% NaCl : cause water to shift from T to B. c. 0.25 NaCl : shift water from B to T. d. NS : shift water from B to T.

b. 3% NaCl : cause water to shift from T to B.

A large bookcase falls upon an elderly man in his home. His left leg is pinned and he cannot move for 2 days until his neighbor finds him. He is hospitalized with massive trauma to his left leg, with resultant rhabdomyolysis (rhabdomyo means striated muscle tissue; lysis means "break down"). His pulses in that foot are unpalpable and the foot is pale and cool. Eventually his foot must be amputated. Initial lab work is drawn that show a CK of 100,000 (normal serum CK is 0 to 200). Why is it so high? a. As a compensatory response, the production of the enzyme creatine kinase (CK) is increased in the cells and then is excreted to "clean up" the cellular debris. b. As a result of injury, the striated cell membranes lose integrity and there is leakage of intracellular substances such as CK into the surrounding tissue bed. c. Creatine kinase (CK) is only found in striated muscle cells, so it makes sense that rhabdomyolysis would result in greater release of CK. d. Local tissue response to injury includes release of toxic, lytic substances such as CK.

b. As a result of injury, the striated cell membranes lose integrity and there is leakage of intracellular substances such as CK into the surrounding tissue bed.

A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype. Which is true about the dad? a. His genotype is ss. b. He is a carrier of sickle cell. c. He likely has the typical S&S of sickle cell. d. All of the above.

b. He is a carrier of sickle cell.

On a more cellular level, which is true regarding the two patients in question 14 (You have two patients whose serum osmolality results are as follows: Albus Dumbledore (Mr. D.) has a serum osmolality of 263. Minerva McGonagall (Ms. M) has a serum osmolality of 326. (normal serum osmo = 280- 295)? a. Mr. D's tissue cells are likely shrunken from fluid being pulled from tissue to blood. b. Ms. M's tissue cells are likely shrunken from fluid being pulled from tissue to blood. c. Ms. M has more dilute blood than Mr. D. d. Mr. D's blood is hyperosmolar compared to normal.

b. Ms. M's tissue cells are likely shrunken from fluid being pulled from tissue to blood.

A large bookcase falls upon an elderly man in his home. His left leg is pinned and he cannot move for 2 days until his neighbor finds him. He is hospitalized with massive trauma to his left leg, with resultant rhabdomyolysis (rhabdomyo means striated muscle tissue; lysis means "break down"). His pulses in that foot are unpalpable and the foot is pale and cool. Eventually his foot must be amputated. After many months the patient finally has recovered enough to be able to get up and have some physical therapy. What change of the musculature will the therapist have to deal with in the injured leg (besides loss of a foot)? a. Presence of decubiti because of scarring. b. Muscle cell shrinkage called atrophy. d. Increase in numbers of muscle cells, called hyperplasia e. Hypertrophy of the striated muscle cells.

b. Muscle cell shrinkage called atrophy

Link the correct answer in question 38 (Because of the decreased influx of cations, the local nerve cell RMPs will be reset from -90mV to -120mV.) with the effect of numbing the skin in the area to be stitched. a. Since the RMPs of the area nerve cells are now more positively charged, they are hypopolarized and therefore will conduct pain sensations very slowly or not at all. b. Since the RMPs of the area nerve cells are now more negatively charged, they are hyperpolarized and therefore will conduct pain sensations very slowly or not at all. c. Since the RMPs of the area nerve cells are now more negatively charged, they are hypopolarized and therefore will be so hyperactive that pain sensation will be negligible. d. Since the RMPs of the area nerve cells are now more positively charged, they are hyperpolarized and therefore will conduct pain sensations very slowly or not at all.

b. Since the RMPs of the area nerve cells are now more negatively charged, they are hyperpolarized and therefore will conduct pain sensations very slowly or not at all.

A patient with a serum calcium of 6.0 (norm = 8.5- 10.5) is most likely to ______ because_______. a. be lethargic: the cells are hypopolarized. b. have muscle spasms: more Na+ has entered the cells. c. be weak: more Na+ has left the cells. d. have hyperirritable muscles: the cells are hyperpolarized.

b. have muscle spasms: more Na+ has entered the cells.

A 55 year old male is in the ER having a myocardial infarction (heart attack, AKA "M.I."), which is caused by coronary arteries that are clogged with fat and narrowed so that not enough oxygen-rich blood is getting to his heart. He admits that his daily nutrition is poor, consisting mainly of high-fat fast food. He has a family history of cardiac disease-- his father had a heart attack at age 46. The patient is obese and is a heavy cigarette smoker-- 2 PPD (packs per day). The patient said he had decided to take up jogging today and after a few minutes began having chest pain, nausea and shortness of breath. He went to the ER and was noted to have profuse diaphoresis (heavy sweating), tachycardia (rapid heart rate), and significant changes on his electrocardiogram (ECG or EKG). The patient recovers from this acute heart attack but his heart is so damaged that subsequently he has many episodes of congestive heart failure and many hospitalizations. In reading the scenario, it is easy to find 4 risk factors—things that "set the stage" for this patient to have a heart attack. They include all the following EXCEPT a. being a heavy cigarette smoker. b. having profuse diaphoresis. c. a parent with heart disease. d. high-fat diet.

b. having profuse diaphoresis.

A patient is hospitalized in renal failure. Because of her kidneys' inability to excrete water, she has generalized edema & a serum sodium of 129. Because the kidneys have also lost the ability to appropriately regulate potassium, she also has a serum potassium of 5.9. These lab results show: a. hypernatremia & hypokalemia. b. hyperkalemia & hyponatremia. c. hyperosmolality & hypernatremia. d. hypoosmolality & hypocalcemia.

b. hyperkalemia & hyponatremia.

A patient who just came out of general anesthesia has lab work done. The serum osmo is 165. The nurse taking care of this patient suspects that the _____ is due to _________. a. hyperosmolality: dehydration. b. hypoosmolality: syndrome of inappropriate ADH (SIADH). c. hypertonicity: SIADH. d. high oncotic pressure: a state of hyperpolarization inside the cells.

b. hypoosmolality: syndrome of inappropriate ADH (SIADH).

A 28-year-old man presents with a low blood pressure due to blood loss from a gunshot wound. The regulatory action that will best compensate for this patient's fluid volume deficit is: a. increased action of the natriuretic peptide system. b. increased action of the RAAS. c. inhibition of renin secretion. d. conversion of aldosterone into angiotensin II.

b. increased action of the RAAS.

The nurse in the previous question (A patient who just came out of general anesthesia has lab work done. The serum osmo is 165. The nurse taking care of this patient suspects that the _____ is due to _________.) would expect all the following S&S EXCEPT: a. signs of cerebral edema such as irritability. b. signs of cerebral cell dehydration such as headache. c. pitting edema d. crackles in the lungs upon auscultation.

b. signs of cerebral cell dehydration such as headache.

A patient that has been recently diagnosed with a neuroma on the sole of his foot is very anxious. Of the following, which information shows that the nurse understands the nomenclature of neoplasms when explaining the situation to the patient? a. "You should have the neuroma removed, as this is a cancer that will spread to other parts of the body." b. "This is most likely a malignancy that will metastasize to your lymph nodes." c. "Neuromas are benign growths that usually will not spread." d. "You will soon have the irresistible urge to put on tap shoes and dance in a Broadway musical."

c. "Neuromas are benign growths that usually will not spread."

A 55-year-old man with emphysema (a type of chronic lung disease) who has smoked 2 packs of cigarettes per day for 40 years is hospitalized for acute onset of cough productive of bloody sputum (sputum=secretions from deep in the lungs). After a few days of testing and treatment, the patient's nurse reads a physician's note on the chart: "I have told the patient that the etiologies of his hemoptysis are: 1) exacerbation of his chronic emphysema and 2) the new diagnosis of lung cancer. The onsets of both were contributed to by his longstanding smoking." The patient asks the nurse for more information. Which of the following explanations to the patient best indicates a full understanding of the patient's situation? a. "You have a disease process that was iatrogenically caused by cigarette smoking." b. "You have a sudden onset of a chronic lung disease that was brought on by lung cancer." c. "The coughing up of blood is caused by a worsening of a disease you've had for a long time, plus a new problem-- lung cancer." d. "These diseases have been creeping up on you for probably 20 years; it just goes to show that you should never have taken up smoking."

c. "The coughing up of blood is caused by a worsening of a disease you've had for a long time, plus a new problem-- lung cancer."

.A child is born to a couple, one of whom is heterozygous for an autosomal dominant disease. The other parent is homozygous normal. What would be the child's chances of having the disease? (Use a Punnett square to figure this out). a. 0% b. 25% c. 50% d. 75%

c. 50%

A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype. What is the percent possibility of this couple's child having sickle cell trait? a. 0% b. 25% c. 50% d. 75%

c. 50%

A 25-year old pregnant women voices concerns about the genetic health of her fetus because she has sickle cell disease. Her husband has been genetically tested and has a heterozygous genotype. What is the percent possibility of this couple's child having the disease, sickle cell anemia? a. 0% b. 25% c. 50% d. 75%

c. 50%

A child is born to a couple, one of whom is a carrier for a sex-linked recessive disease. The other parent has the disease ("having" the disease means the phenotype is seen—ie, S&S). What would be the chances that the couple has a child with the disease? (Use a Punnett square to figure this out.) a. 0% b. 25% c. 50% d. 75%

c. 50%

A patient in the ER is about to get a laceration stitched up. First the ER nurse practitioner (NP) will infiltrate the area with Lidocaine, a drug that will prevent the patient from feeling pain as the stitches go in. The medication's mechanism of action is to change the permeability of nerve cell membranes so that they decrease the number of Na+ ions that are allowed to come into the cell. Using critical thinking and knowledge of RMP issues, what do you think is the next step? a. The nerve cells in the area become filled with anions and the RMP is reset from -90mV to -60mV. b. Because of the increased influx of cations, the local nerve cell membranes become more positively charged. c. Because of the decreased influx of cations, the local nerve cell RMPs will be reset from -90mV to -120mV. d. The sodium/potassium pump of the cell membranes will cease to work properly, and the cells will become incapable of holding their normal RMP charge.

c. Because of the decreased influx of cations, the local nerve cell RMPs will be reset from -90mV to -120mV.

A 55 year old male is in the ER having a myocardial infarction (heart attack, AKA "M.I."), which is caused by coronary arteries that are clogged with fat and narrowed so that not enough oxygen-rich blood is getting to his heart. He admits that his daily nutrition is poor, consisting mainly of high-fat fast food. He has a family history of cardiac disease-- his father had a heart attack at age 46. The patient is obese and is a heavy cigarette smoker-- 2 PPD (packs per day). The patient said he had decided to take up jogging today and after a few minutes began having chest pain, nausea and shortness of breath. He went to the ER and was noted to have profuse diaphoresis (heavy sweating), tachycardia (rapid heart rate), and significant changes on his electrocardiogram (ECG or EKG). The patient recovers from this acute heart attack but his heart is so damaged that subsequently he has many episodes of congestive heart failure and many hospitalizations. Which mini-concept map do you think best describes accurate linkage between underlying pathophysiology and signs and symptoms (S&S) described in this scenario? a. Jogging increased heart rateblood pumped throughout body fastertissues (including lungs and stomach) receive too much bloodpatient complains of shortness of breath and nausea. b. History of heart disease in familypatient worries about it constantlybecomes anxioussmokes too muchnicotine causes narrowing of all arteries in body, including coronariesheart attack from narrowed coronaries. c. High levels of fat in the blood from high-fat dietclogs in coronary arteries develop over time oxygenated blood cannot get to distal tissues of heartunoxygenated tissues "cry out" (send pain messages to brain) patient complains of chest pain. d. Obesity increased pressure on diaphragmbreathing becomes more difficultshortness of breathless oxygen EKG changes.

c. High levels of fat in the blood from high-fat dietclogs in coronary arteries develop over time oxygenated blood cannot get to distal tissues of heartunoxygenated tissues "cry out" (send pain messages to brain) patient complains of chest pain.

If you had a patient whose labwork showed that he was hyperproteinemic, what would you know about that patient? a. He has a low osmotic pressure. b. He has a low blood oncotic pressure. c. His blood is more concentrated than usual. d. You may need to hang an IV bottle of albumin.

c. His blood is more concentrated than usual.

The parents of a five year old girl complain anxiously to her pediatrician that in the last couple of weeks, no matter how much she eats, she keeps losing weight. She appears quite thin, well below her normal weight. Her blood sugar is 300 (normal range 70-99). She is diagnosed with Type I diabetes mellitus (DM 1). If ABGs were done on this patient, you would expect all the following EXCEPT: a. a blood pH of 7.32 because sustained gluconeogenesis causes acidic byproducts to accumulate. b. a HCO3 of 20 because the high numbers of acids in her body "take over" and "overcome" the HCO3, which then diminishes in number. c. a HCO3 of 30 because the low numbers of acids in her body stimulate increase in HCO3. d. this acid/base imbalance to be called metabolic acidosis because it is an acidotic state caused by a metabolic disorder.

c. a HCO3 of 30 because the low numbers of acids in her body stimulate increase in HCO3.

A 59 year old man is diagnosed with CML—chronic myelocytic leukemia. All of the following help to explain the genetic etiology of the CML EXCEPT a. a chromosomal structural defect called translocation occurs. b. pieces of two chromosomes are exchanged. c. a chromosomal aneuploidy defect called translocation occurs. d. a short, defective chromosome called the Philadelphia chromosome develops.

c. a chromosomal aneuploidy defect called translocation occurs.

An 80-year-old patient is in shock from loss of blood following an accident. His vital signs are: BP 80/50 (normal ~ 120/80), HR 120 (norm = 60-100), RR 20 (norm = 12 to 20), T 98.6 (norm ~ 98.6). The patient would also most likely have all of the following EXCEPT a. S&S of cool feet and hands from the body's compensatory response to shock. b. S&S of feeling faint and weak from blood loss. c. a risk factor of shock. d. a more guarded (ie, "poorer") prognosis because of his age.

c. a risk factor of shock.

A large bookcase falls upon an elderly man in his home. His left leg is pinned and he cannot move for 2 days until his neighbor finds him. He is hospitalized with massive trauma to his left leg, with resultant rhabdomyolysis (rhabdomyo means striated muscle tissue; lysis means "break down"). His pulses in that foot are unpalpable and the foot is pale and cool. Eventually his foot must be amputated. Because of massive cellular injury, myoglobin leaks from cells into blood. The patient eventually develops kidney failure from this myoglobinemia. All the following are true about this situation EXCEPT a. the patient may ultimately need injections of erythropoietin because of the ailing kidneys' failure to adequately create it. b. myoglobinuria will likely be present acutely due to "spillage" of excess of myoglobin into the urine. c. erythropoietin will be dangerously high in the blood secondary to kidney over-secretion of this hormone. d. the etiology of the eventual kidney failure is most likely the high amounts of myoglobin that overwhelm the kidneys' ability to process it.

c. erythropoietin will be dangerously high in the blood secondary to kidney over-secretion of this hormone.

All of the following are accurate possible findings in the patient above (cancer, cant eat, lost 80 lbs, generalized edema, serum protein levels low) EXCEPT that a. he has confusion due swollen brain cells. b. he has crackles in his lungs from fluid in the alveoli (lung tissue). c. his serum osmolality is 302 (norm = 280- 295). d. he will need a hypertonic IV solution to return fluid status to normal.

c. his serum osmolality is 302 (norm = 280- 295)

A diabetic patient has pathological changes to his arteries that result in narrowing and blockage. He is diagnosed with gangrene of the toes (gangrene is when LOTS of cells die).. Lab work is drawn and shows an elevated CK. Which pathological process accurately explains this type of occurrence? a. necrosisgangreneischemia creatine kinase spillage into blood. b. infarct cellular differentiation release of urea. c. ischemia cell injuryswellingspillage of cellular enzymes into blood. d. metastasis superoxide dismutase release of free radicals.

c. ischemia cell injuryswellingspillage of cellular enzymes into blood.

A 78 year old patient with cancer of the esophagus has not been able to eat, has lost 80 pounds and appears cachectic (extremely thin & wasted; the noun is cachexia). His breath smells fruity, like acetone. His pH is 7.14 and HCO3 18. Looking at his pH and HCO3, plus the corroborating patient picture, what acid/base imbalance is he in? a. respiratory alkalosis. b. metabolic alkalosis. c. metabolic acidosis. d. respiratory acidosis.

c. metabolic acidosis.

A patient has been vomiting copiously for 3 days. He is probably in ___ because _____. a. metabolic acidosis : vomiting often leads to hyperventilation. b. respiratory alkalosis : vomiting often leads to hyperventilation c. metabolic alkalosis : vomiting of the normal acidic digestive secretions of the stomach eventually depletes the body's acids. d. metabolic acidosis : vomiting of the normal acidic digestive secretions of the stomach eventually depletes the body's acids.

c. metabolic alkalosis : vomiting of the normal acidic digestive secretions of the stomach eventually depletes the body's acids.

A patient who smokes expresses concern to his nurse about the metaplastic changes of the bronchi that were seen during his bronchoscopy. The nurse bases her response on the knowledge that this type of cellular change is a. an irreversible cellular adaptation pattern. b. considered a precancerous cellular change. c. reversible if the change agent is removed. d. due to a physiologic hyperplasia

c. reversible if the change agent is removed.

As a result of the action in the previous question (increased action of RAAS), all the following will occur EXCEPT: a. the patient's body will "hang on" to fluids. b. Na+ will be retained by the kidneys. c. water excretion into the urine will increase. d. blood pressure will increase.

c. water excretion into the urine will increase.

The physiologic process underlying fluid shifts in the patient situation above is that a. "concentration calls" fluid into hypoosmolar compartments from hyperosmolar ones. b. the principle of diffusion results in albumin molecules going from lower to higher concentration. c. "concentration calls" fluid into compartments with higher oncotic pressure from compartments with lower oncotic pressure. d. the proteinemia means that protein molecules will diffuse throughout the blood and tissue.

c."concentration calls" fluid into compartments with higher oncotic pressure from compartments with lower oncotic pressure.

Which sets of sentences match each other correctly? (Read very carefully.) a. After several days of little sleep and very stressful life events a student's cold evolves into pneumonia. Insomnia and stress are precipitating factors for the pneumonia. b. A person with a chronic lung disease gets pneumonia. The pneumonia is considered an acute illness. c. Freshly oxygenated blood flows from the aorta through coronary arteries to distal parts of the heart muscle. Blockage in the coronaries would cause decreased oxygenation in the cardiac muscle tissue that is proximal to the blockage. d. A and B.

d. A and B.

A child with sickle cell anemia presents with pain all over, especially the joints. Which of the following best links the patho with S&S? a. Cyst formation in the kidneys leads to blood spillage from the circulation into the urine, thus causing anemia. b. A single-gene mutation causes malfunction of genetic coding for clotting properties, leading to bleeding and ischemic pain of the joints. c. Chromosomal aberrancy causes malformation of RBCs in the blood supply to the joints and subsequent pain due to lack of oxygen. d. A single-gene mutation causes malfunction in RBC O2-carrying capacity, leading to ischemic pain in the joint tissues.

d. A single-gene mutation causes malfunction in RBC O2-carrying capacity, leading to ischemic pain in the joint tissues.

A 78 year old patient with cancer of the esophagus has not been able to eat, has lost 80 pounds and appears cachectic (extremely thin & wasted; the noun is cachexia). His breath smells fruity, like acetone. His pH is 7.14 and HCO3 18. Link aspects of his clinical presentation to the pathophysiology underlying them. a. Patient can't eat hypoglycemiainsulin secreted from pancreas triggers glycogenolysis as a back-up plan raises blood sugar but byproducts include ketones. b. Difficulty breathing increased metabolic needsuses up all energy sources body begins to use HCO3 as source of energyHCO3 depleted HCO3 decreases to 18, causing pH to increase from normal to 7.14. c. Chronic illnessincreased stressincrease in counterregulatory hormonesglycogenesis triggeredtoo much glucose being stored rather than being readily availablecachexia. d. Given the description of the patient's debilitated state, he is probably in sustained gluconeogenesisgives energy but also increases accumulation of ketones body tries to get rid of them via many ways, including as acetone in the breath.

d. Given the description of the patient's debilitated state, he is probably in sustained gluconeogenesisgives energy but also increases accumulation of ketones body tries to get rid of them via many ways, including as acetone in the breath.

A 55-year-old man with emphysema (a type of chronic lung disease) who has smoked 2 packs of cigarettes per day for 40 years is hospitalized for acute onset of cough productive of bloody sputum (sputum=secretions from deep in the lungs). After a few days of testing and treatment, the patient's nurse reads a physician's note on the chart: "I have told the patient that the etiologies of his hemoptysis are: 1) exacerbation of his chronic emphysema and 2) the new diagnosis of lung cancer. The onsets of both were contributed to by his longstanding smoking." Based on all the information you have on the patient, which statement is most likely correct? a. The patient has a poor prognosis because of the comorbidities of lung cancer and cigarette smoking. b. Lung cancer was a sequela of the bloody sputum. c. A precipitating factor for the acute hospitalization was overexertion when the patient started an exercise class. d. Heavy cigarette smoking was a risk factor in the patient's developing emphysema and lung cancer.

d. Heavy cigarette smoking was a risk factor in the patient's developing emphysema and lung cancer.

You have two patients whose serum osmolality results are as follows: Albus Dumbledore (Mr. D.) has a serum osmolality of 263. Minerva McGonagall (Ms. M) has a serum osmolality of 326. (normal serum osmo = 280- 295). Based on understanding the links between fluid imbalances, lab results, and S&S, you will expect that a. Ms. M. will have an overall puffy appearance. b. Mr. D will have poor skin turgor and dry mucus membranes. c. Ms. M. will need a hypertonic IV to get her fluid status back to normal. d. Mr. D will have generalized pitting edema.

d. Mr. D will have generalized pitting edema.

Which mini-concept map has correct linkage in describing cancer genesis? a. angiogenesiscachexialack of nutritioncellular starvationcancerous changes b. growth factor signalsincreased cellular differentiationanaplasiacancer. c. oncogeneclonal proliferationincreased cellular differentiationcancer. d. oncogeneclonal proliferationanaplasiacancer cells.

d. oncogeneclonal proliferationanaplasiacancer cells.

A 55 year old male is in the ER having a myocardial infarction (heart attack, AKA "M.I."), which is caused by coronary arteries that are clogged with fat and narrowed so that not enough oxygen-rich blood is getting to his heart. He admits that his daily nutrition is poor, consisting mainly of high-fat fast food. He has a family history of cardiac disease-- his father had a heart attack at age 46. The patient is obese and is a heavy cigarette smoker-- 2 PPD (packs per day). The patient said he had decided to take up jogging today and after a few minutes began having chest pain, nausea and shortness of breath. He went to the ER and was noted to have profuse diaphoresis (heavy sweating), tachycardia (rapid heart rate), and significant changes on his electrocardiogram (ECG or EKG). The patient recovers from this acute heart attack but his heart is so damaged that subsequently he has many episodes of congestive heart failure and many hospitalizations. Without even having further knowledge of course material related to MI's, you can tell a lot about the scenario from careful reading and knowledge of basic patho verbiage. Example: The paragraph above suggests that the direct pathophysiologic etiology of the heart attack (MI) is most likely related to a. not eating green vegetables. b. congestive heart failure. c. lack of oxygen that narrows the coronary arteries. d. oxygen not reaching tissue that is distal to narrowing of the coronary arteries.

d. oxygen not reaching tissue that is distal to narrowing of the coronary arteries.

The parents of a five year old girl complain anxiously to her pediatrician that in the last couple of weeks, no matter how much she eats, she keeps losing weight. She appears quite thin, well below her normal weight. Her blood sugar is 300 (normal range 70-99). She is diagnosed with Type I diabetes mellitus (DM 1). In this scenario, the explanation that bests links pathophysiology with S&S in this child is that in DM1, the pancreas a. quits producing glucagon so that glycogen stores are inaccessible, thus causing weight loss. b. increases insulin production so that glucose stays in the blood, causing hyperglycemia. c. quits producing insulin so that glycogenolysis is stimulated and too much glucose enters the blood. d. quits producing insulin so that glucose cannot be used as energy in the cells, thus causing the body to burn up fat and protein for energy.

d. quits producing insulin so that glucose cannot be used as energy in the cells, thus causing the body to burn up fat and protein for energy.

A young, otherwise healthy patient is admitted to the hospital with a diagnosis of heart failure of unknown cause. The etiology of the heart failure would be termed a. iatrogenic. b. idiopathic. c. nosocomial. d. acute.

b. idiopathic.

A person has hemophilia. Which is the correct genotype? a. HH b. XHY c. XhY d. hh

c. XhY