PHAR 512 ONCO PROSTATE CANCER

What are the LHRH agonists?

Goserelin Histrelin Leuprolide Triptorelin

What is the treatment for a patient with prostate cancer who is castration naive without metastases?

LHRH agonist +/- antiandrogen LHRH antagonist

What are the antiandrogens

Abiraterone Apalutamide Bicalutamide Enzalutamide Flutamide Nilutamide

How do you manage tumor flare?

Add an antiandrogen

What is the treatment for a patient with prostate cancer who is castration resistant without metastates?

Continue LHRH agonist or antagonist to maintain castrate levels of testosterone and ADD Abiraterone with prednisone Docetaxel + prednisone Enzalutamide

What are the LHRH antagonists?

Degarelix

What are long term complications associated with ADT?

Increased fracture risk (get regular screenings and take calcium and vit D) Decreased muscle mas Increased risk of CVD and DM (Regular screening and exercise)

What is the treatment for a patient with prostate cancer who is castration naive with metastases?

LHRH agonist + antiandrogen OR LHRH antagonist OR LHRH antagonist PLUS abiraterone with prednisone OR LHRH antagonist PLUS docetaxel x 6 cycles

What does castration-naive mean?

Patient is not on Androgen Depravation Therapy (ADT) at the time of progression

What does castration resistant mean?

Prostate cancer that progresses clinically, radiographically, or biometrically despite castrate levels of testosterone

Supportive care for colon cancer

Zoledronic acid or denosumab (WITH CALCIUM AND VITAMIN D) to prevent skeletal complications in patients with bone metastases