Ross Immunology True/False Practice Exam 2
A hybridoma cell produces antibodies of different isotypes.
F
A major function of the complement system is the destruction of intracellular bacteria.
F
Bacterial somatic ("O") antigen describes the antigenic nature of lipid A of bacterial polysaccharide.
F
Cytotoxic T cells use a single mechanism to kill cells.
F
Effector CTL requires one signal for complete activation; on the other hand, effector Th requires two signals for complete activation.
F
Hapten is another term for antigen.
F
Host cells that present peptide antigens to T helper cells or CTLs are collectively referred to as professional APCs.
F
IgA is produced against T-independent antigens.
F
IgG functions more effectively than IgM in complement activation.
F
IgM is the predominant Ig produced in the mucosal immune system.
F
In birds, the early events in B cell development occur in Peyer's patches.
F
Naive T cells and effector T cells are long-lived cells.
F
Naive T cells constitutively express CTLA-4 cell surface receptors on their surface.
F
Neutrophil activation is the first step in neutrophil recruitment to inflamed tissue.
F
Somatic hypermutation which occurs in proliferating B cells, is critical to isotype switching.
F
Th2 cells are the predominant helper cells that secrete cytokines which mediate the elimination of intracellular microbes from the body.
F
The granzymes of CTLs mediate target cell death by activating the cell's extrinsic apoptotic pathway.
F
The ligand for the killer cell activatory receptor (KAR) of an NK cell is Class I MHC molecule.
F
The plateau phase of antibody production is characterized by a high level of antigen processing and presentation by professional APCs.
F
Activated B cells produce in gut-associated lymphatic tissues may populate different mucosal sites by way of the bloodstream.
T
Antibodies are glycoproteins.
T
Antibodies are important in targeting virus-infected cells to be killed by macrophages and natural killer cells.
T
Antigens are generally multivalent.
T
CTLs are MHC class I-restricted T lymphocytes.
T
Cytokines are critical to the induction of the so-called systemic inflammatory response system (SIRS).
T
Cytolytic T lymphocytes adhere to target cells by CD11aCD18.
T
Each terminally differentiated plasma cell is derived from a specific B cell and produces antibodies of a single class or subclass.
T
Interleukin-10 is a potent suppressor of macrophage function.
T
Lymphocytes activated at one mucosal surface may become distributed through-out the mucosa-associated lymphatic tissues.
T
Mechanisms that contribute to TCR or BCR diversity include gene rearrangement and addition of N-region nucleotides to the cut ends of V(D)J genes.
T
Membrane Igs (BCRs) are slightly larger than their secreted counterparts.
T
Microorganisms engulfed by phagocytic cells are killed in intracellular vesicles called phagolysosomes.
T
Monoclonal antibodies are antibodies specific for a single epitope.
T
Most antigens are multivalent.
T
Most of the T cells generated daily never leave the thymus as mature T cells.
T
Plasma cells are antibody factories.
T
Resistant bacterial flora release toxic products called bacteriocins that either kill or inhibit incoming pathogens.
T
Secondary follicles are primary follicles with germinal centers .
T
Self-reactive immature B cells can be rescued from negative selection by the expression of a different light chain.
T
Serum IgM cannot activate complement by itself.
T
Some parasites evade host immune defenses by acquiring an outer coat of host proteins.
T
Stable expression of cell surface MHC molecule requires a peptide bound to the MHC cleft.
T
The five antibody classes have different effector functions, serum concentration, and half-lives.
T
Tissue macrophages can proliferate locally, producing more cells.
T
When fully activated, cells of the adaptive immune response always undergo clonal expansion.
T
