Ross Immunology True/False Practice Exam 2

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A hybridoma cell produces antibodies of different isotypes.

F

A major function of the complement system is the destruction of intracellular bacteria.

F

Bacterial somatic ("O") antigen describes the antigenic nature of lipid A of bacterial polysaccharide.

F

Cytotoxic T cells use a single mechanism to kill cells.

F

Effector CTL requires one signal for complete activation; on the other hand, effector Th requires two signals for complete activation.

F

Hapten is another term for antigen.

F

Host cells that present peptide antigens to T helper cells or CTLs are collectively referred to as professional APCs.

F

IgA is produced against T-independent antigens.

F

IgG functions more effectively than IgM in complement activation.

F

IgM is the predominant Ig produced in the mucosal immune system.

F

In birds, the early events in B cell development occur in Peyer's patches.

F

Naive T cells and effector T cells are long-lived cells.

F

Naive T cells constitutively express CTLA-4 cell surface receptors on their surface.

F

Neutrophil activation is the first step in neutrophil recruitment to inflamed tissue.

F

Somatic hypermutation which occurs in proliferating B cells, is critical to isotype switching.

F

Th2 cells are the predominant helper cells that secrete cytokines which mediate the elimination of intracellular microbes from the body.

F

The granzymes of CTLs mediate target cell death by activating the cell's extrinsic apoptotic pathway.

F

The ligand for the killer cell activatory receptor (KAR) of an NK cell is Class I MHC molecule.

F

The plateau phase of antibody production is characterized by a high level of antigen processing and presentation by professional APCs.

F

Activated B cells produce in gut-associated lymphatic tissues may populate different mucosal sites by way of the bloodstream.

T

Antibodies are glycoproteins.

T

Antibodies are important in targeting virus-infected cells to be killed by macrophages and natural killer cells.

T

Antigens are generally multivalent.

T

CTLs are MHC class I-restricted T lymphocytes.

T

Cytokines are critical to the induction of the so-called systemic inflammatory response system (SIRS).

T

Cytolytic T lymphocytes adhere to target cells by CD11aCD18.

T

Each terminally differentiated plasma cell is derived from a specific B cell and produces antibodies of a single class or subclass.

T

Interleukin-10 is a potent suppressor of macrophage function.

T

Lymphocytes activated at one mucosal surface may become distributed through-out the mucosa-associated lymphatic tissues.

T

Mechanisms that contribute to TCR or BCR diversity include gene rearrangement and addition of N-region nucleotides to the cut ends of V(D)J genes.

T

Membrane Igs (BCRs) are slightly larger than their secreted counterparts.

T

Microorganisms engulfed by phagocytic cells are killed in intracellular vesicles called phagolysosomes.

T

Monoclonal antibodies are antibodies specific for a single epitope.

T

Most antigens are multivalent.

T

Most of the T cells generated daily never leave the thymus as mature T cells.

T

Plasma cells are antibody factories.

T

Resistant bacterial flora release toxic products called bacteriocins that either kill or inhibit incoming pathogens.

T

Secondary follicles are primary follicles with germinal centers .

T

Self-reactive immature B cells can be rescued from negative selection by the expression of a different light chain.

T

Serum IgM cannot activate complement by itself.

T

Some parasites evade host immune defenses by acquiring an outer coat of host proteins.

T

Stable expression of cell surface MHC molecule requires a peptide bound to the MHC cleft.

T

The five antibody classes have different effector functions, serum concentration, and half-lives.

T

Tissue macrophages can proliferate locally, producing more cells.

T

When fully activated, cells of the adaptive immune response always undergo clonal expansion.

T


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