Thyroid-Stimulating Hormone

TSH: Produced by

Anterior Pituitary

TSH: Hyposecretion

Cretinism in children; myxedema in adults

TSH: Hypersecretion

Hyperthyroidism; effects similar to those of Graves' disease, in which antibodies mimic TSH Graves Disease: - Anxiety and irritability - A fine tremor of your hands or fingers - Heat sensitivity and an increase in perspiration or warm, moist skin - Weight loss, despite normal eating habits - Enlargement of your thyroid gland (goiter) - Change in menstrual cycles - Erectile dysfunction or reduced libido - Frequent bowel movements - Bulging eyes (Graves' ophthalmopathy) - Fatigue - Thick, red skin usually on the shins or tops of the feet (Graves' dermopathy) - Rapid or irregular heartbeat (palpitations)

TSH: Regulation of Release

Stimulated by TRH and in infants indirectly by cold temperatures Inhibited by feedback inhibition exerted by thyroid hormones on anterior pituitary and hypothalamus and by GHIH

TSH: Target and Effect

Thyroid; increase synthesis/release of TH