Ch21 cell-mediated defense: CD8 activation & co-stimulation

Step 7

Co-stimulation occurs & the cytotoxic T (Tc) Cell is then fully activated.

Step5

The Class I MHC with the viral fragment (or cancer peotide) undegoes exocytosis & is then displayed on the cell surface of the nucleated cell.

Step 3

The Class I MHC with the viral fragment is then loaded into a vesicle

Step 6

The T cell receptor on the Cytotoxic T Cell binds to the Class I MHC protein.

Step 1

The rough endoplasmic reticulum in the nucleated cell synthesizes a Class I MHC protein

Step4

The vesicle then transports the liaded Class I MHC through the cytoplam

Step 2

The viral fragment (or cancerous peptide) the loaded on the class I MHC in the rough endoplasmic reticulum