Ch21 cell-mediated defense: CD8 activation & co-stimulation
Step 7
Co-stimulation occurs & the cytotoxic T (Tc) Cell is then fully activated.
Step5
The Class I MHC with the viral fragment (or cancer peotide) undegoes exocytosis & is then displayed on the cell surface of the nucleated cell.
Step 3
The Class I MHC with the viral fragment is then loaded into a vesicle
Step 6
The T cell receptor on the Cytotoxic T Cell binds to the Class I MHC protein.
Step 1
The rough endoplasmic reticulum in the nucleated cell synthesizes a Class I MHC protein
Step4
The vesicle then transports the liaded Class I MHC through the cytoplam
Step 2
The viral fragment (or cancerous peptide) the loaded on the class I MHC in the rough endoplasmic reticulum