Exam 2 Hematology Ch. 6 - Hemoglobin - Quiz & Review Questions
Which of the following is considered a normal hemoglobin concentration in an adult? 9.1 g/dL 21.2 g/dL 1.8 g/dL 14.8 g/dL
14.8 g/dL
8. Which of the following is considered a normal hemoglobin concentration in an adult male? A. 11.0 g/dL B. 21.0 g/dL C. 15.0 g/dL D. 9.0 g/dL
15.0 g/dL
Which of the following sets of values represents a normal adult hemoglobin distribution? 90% A, 5% A2, 5% F 96% A, 2% A2, 4% F 90% A, 8% A2, 2% F 97% A, 1% F, 2% A2
97% A, 1% F, 2% A2
Which of the following causes a left shift in the oxygen dissociation curve (normal blood pH: 7.35-7.45)? An increased 2, 3-BPG concentration An increased pCO2 A body temperature of 103°F A blood pH of 7.54
A blood pH of 7.54
A high concentration of H+ ions will have what kind of effect on the oxygen dissociation curve? Cannot be determined based on information given A shift to the right No effect on the oxygen dissociation curve A shift to the left
A shift to the right
The majority of carbon dioxide is transported in the body: By dissolving in plasma. As methemoglobin As carbonic acid. By binding to hemoglobin.
As carbonic acid.
Which non-alpha-globin chain composes the predominating normal hemoglobin in adults? Beta Delta Zeta Gamma
Beta
One of the most important buffer systems of the body is the: A. Chloride Shift B. Bohr Effect C. Heme-heme interaction D. ODC
Bohr Effect
How is globin chain production regulated in the body? By regulating the number of RBCs produced By regulating the amount of heme produced By regulating the rate of transcription for protein synthesis By regulating the amount of iron incorporated into the heme moiety
By regulating the rate of transcription for protein synthesis
How can you detect methemoglobin in the laboratory? By looking at the patient's blood color—it will be blue. By spectral analysis at 630 nm By spectral analysis at 541 nm By hemoglobin quantitation using acid elution techniques
By spectral analysis at 630 nm
Which abnormal hemoglobin contains a molecule of carbon monoxide? Methemoglobin Carboxyhemoglobin Sulfhemoglobin Deoxyhemoglobin
Carboxyhemoglobin
When blood leaves the lungs and reaches the tissues, the PO2 decreases and the P50 level of O2 will: Decrease Equilibrate to the PCO2 level Increase Not change
Decrease
The measurement of glycosylated hemoglobin is used as an indicator of what disease process? Oxygen affinity Anemia Diabetes Cyanosis
Diabetes
Which of the following is responsible for incorporating iron into the heme molecule? Ferrochelatase ALA dehydrase Uroporphyrinogen III PBG deaminase
Ferrochelatase
What structure within hemoglobin identifies the type of hemoglobin? Heme group Salt bond Tetrameric molecule Globin chain
Globin chain
Which of the following is not a breakdown product of hemoglobin: Iron Haptoglobin Biliverdin Globin
Haptoglobin
Choose the hemoglobin that has the highest oxygen affinity. Methemoglobin Sulfhemoglobin Hb F Hb A
Hb F
1. Which of the following types of hemoglobin is the major component of adult hemoglobin? A. Hba B. HbF C. HbA2 D. Hb Portland
Hba
Which of the following conditions produces a favorable environment for hemoglobin to bind to oxygen? (Normal body temperature is <100° F; normal blood pH: 7.35-7.45.) High PO2 A high 2,3-BPG concentration A blood pH of 7.31 A body temperature of 102°F
High PO2
Which of the following conditions produces a favorable environment for hemoglobin to bind to oxygen? (Normal body temperature is <100° F; normal blood pH: 7.35-7.45.) High PO2 A body temperature of 102°F A blood pH of 7.31 A high 2,3-BPG concentration
High PO2
What conditions can be caused by acquired nonfunctional hemoglobins? Decrease in deoxyhemoglobin Sulfhemoglobin production Hypoxia and iron in ferric state Hypoxia and cyanosis
Hypoxia and cyanosis
In the complete hemoglobin structure, iron is: Attached to the alpha-globin chains In the protoporphyrin ring In the mitochondria Attached to the non-alpha-globin chain
In the protoporphyrin ring
An anemic patient has increased serum bilirubin. Which of the following laboratory test results would indicate intravascular hemolysis in a patient? Decreased hemopexin-heme complex Decreased α - β dimers Increased methemalbumin Increased haptoglobin
Increased methemalbumin
10. A patient with an anemia due to increased extravascular hemolysis would likely present with which of the following lab results? A. Increased haptoglobin B. Hemoglobinuria C. Normal hemoglobin and hematocrit D. Increased serum bilirubin
Increased serum bilirubin
9. Haptoglobin can become depleted in: A. Inflammatory conditions B. Intravascular hemolysis C. Infectious diseases D. Kidney disease
Intravascular hemolysis
What element is central to all the structures of a hemoglobin molecule? Nitrogen Oxygen Water Iron
Iron
During extravascular hemolysis, which of the following hemoglobin components are physiologically recycled? Iron and heme Heme and globin Haptoglobin and heme Iron and globin
Iron and globin
Which of the following abnormal hemoglobins is formed when iron is in the ferric state? Sulfhemoglobin Oxyhemoglobin Carboxyhemoglobin Methemoglobin
Methemoglobin
Which of the following is an expression of the oxygen affinity of hemoglobin? Deoxyhemoglobin PCO2 P50 Oxyhemoglobin
P50
Which of the following blood vessels have the highest pO2? Veins Pulmonary veins Pulmonary arteries Capillary beds
Pulmonary veins
Oxyhemoglobin is in the _______ configuration. This is achieved by the _______ of 2, 3-BPG. Relaxed; presence Tense; presence Tense; absence Relaxed; absence
Relaxed; absence
When mutations occur in the globin chains of hemoglobin, what two interactions can be impaired? Heme synthesis and affinity Iron binding and stability Stability and hemoglobin-oxygen affinity Iron regulation and affinity
Stability and hemoglobin-oxygen affinity
An elevated hemoglobin A1C indicates that: The patient is anemic. The patient has an elevated hemoglobin. The patient's RBCs have been exposed to an elevated blood glucose for a prolonged period of time. The patient's RBCs need glucose
The patient's RBCs have been exposed to an elevated blood glucose for a prolonged period of time.
Fetal hemoglobin is composed of what two globin chains? Two alpha, two beta Four gamma Two alpha, two gamma Two alpha, two delta
Two alpha, two gamma
When iron is depleted from the developing erythrocyte, the: A. synthesis of heme is increased B. activity of ALAS is decreased C. formation of globin chains stops D. heme synthesis is not affected
activity of ALAS is decreased
7. During exercise, the oxygen affinity of hemoglobin is: A. Increased in males but not females B. decreased due to production of heat and lactic acid C. 15.0 g/dL D. affected only if the duration is more than 1 hour
decreased due to production of heat and lactic acid
When the H+ concentration in blood increases, the oxygen affinity of hemoglobin: A. increases B. is unaffected C. decreases D. cannot be measured
decreases
2,3-BPG combines with which type of hemoglobin? A. oxyhemoglobin B. relaxed structure of hemoglobin C. deoxyhemoglobin D. aB dimer
deoxyhemoglobin
Which of the following is the correct molecular structure of hemoglobin? A. four heme groups, two iron, two globin chains B. two heme groups, two iron, four globin chains C. two heme group, four iron, four globin chains D. four heme group, four iron, four globin chains
four heme group, four iron, four globin chains
What are the chain designations for hemoglobin F? α2β2 α2δ2 α2ε2 α2γ2
α2γ2
