Heme First Exam Quizzes
What component of the erythrocyte is most responsible for its cytoskeleton and cellular integrity?
Cytoskeletal proteins
Soluble transferrin receptor (sTFR) levels increase when intracellular iron levels are
Decreased
What is the main site for iron storage in the bone marrow?
macrophages
Which splenic process removes inclusions from red blood cells?
Macrophages
What bone marrow cell can differentiate into all of the blood cells?
The stem cell
How many molecules of oxygen can one molecule of hemoglobin carry?
4
The breakdown products of heme go through several biochemical degradations to form
After phagocytosis by the splenic macrophages, hemoglobin is released. It is broken down into its component parts of globin chains and heme, heme further degraded into forming bilirubin
How do cells get from the bone marrow into peripheral circulation?
As mature blood cells come into contact with endothelial cells in the bone marrow, they bind to the surface via a receptor mediated process.
which is true of red cell precursors as they mature?
Basophilia decreases as the red cell matures
Which morphologic characteristic is representative of apoptosis?
Cell shrinkage
Erythropoitin is a growth factor affecting erythroid progenitors and is produced by what organ?
Erythropoitin is a growth factor affecting erythroid progenitors and is produced by the kidney when it senses apoxia
Whenever hematopoiesis occurs outside the bone marrow in an adult , other than lymphopoiesis in lymphatic tissue it is called
Extramedullary hematopoiesis
Good dietary sources of iron include all except
Fruit does not contain iron
Where is the largest percentage of iron in the body located?
Hemoglobin
The following hemoglobin's are found in a normal human adult except
Hemoglobin gower-2
low white blood cell count
Leukopenia
What mechanism is responsible for the destruction of the majority of normal senescent erythrocytes?
Phagocytosis by macrophages in the spleen
Where is heme produced?
RBC precursors in the bone marrow
When compared with mature erythrocytes
Reticulocytes still contain some RNA
A test that is positive in all patients who have the disease but also in some who do not have the disease is
Sensitivity (diagnostic)
What is the most responsible for the strength and pliancy of the red blood cell membrane?
Spectrin
Heme is composed of iron and
Zinc protoporphyrin (ZPP) accumulates in red blood cells.
Where are surface markers that help in cell identification found?
cell membrane
Quality assurance
encompasses everything from the test order by the physician to the reporting of results to the correct patient chart
Glucose 6 phosphate dehydrogenase is
enzyme in the hexose monophosphate pathway and is important for maintaining reduced glutathione in the red cells
When hematopoiesis occurs in the liver in an adult it is called
extramedullary hematopoiesis
What important function does 2,3-BPG perform?
facilitates the delivery of oxygen to tissue
Select the condition where an acute increase in ferritin levels can be detected without a specific increase in the amount of systemic body iron?
infections, sequesters iron away from the bacteria
Heme synthesis takes place primarily in the
mitochondria
After birth, where does hematopoiesis predominately occur?
occurs in the bone marrow
Globin chains are synthesized
on the ribosomes in the cytoplasm of a developing RBC
Apoptosis is
programmed cell death.
Hemoglobin A is composed of
two pairs of unlike polypeptide chains, each of these chains containing one heme group