Heme First Exam Quizzes

What component of the erythrocyte is most responsible for its cytoskeleton and cellular integrity?

Cytoskeletal proteins

Soluble transferrin receptor (sTFR) levels increase when intracellular iron levels are

Decreased

What is the main site for iron storage in the bone marrow?

macrophages

Which splenic process removes inclusions from red blood cells?

Macrophages

What bone marrow cell can differentiate into all of the blood cells?

The stem cell

How many molecules of oxygen can one molecule of hemoglobin carry?

4

The breakdown products of heme go through several biochemical degradations to form

After phagocytosis by the splenic macrophages, hemoglobin is released. It is broken down into its component parts of globin chains and heme, heme further degraded into forming bilirubin

How do cells get from the bone marrow into peripheral circulation?

As mature blood cells come into contact with endothelial cells in the bone marrow, they bind to the surface via a receptor mediated process.

which is true of red cell precursors as they mature?

Basophilia decreases as the red cell matures

Which morphologic characteristic is representative of apoptosis?

Cell shrinkage

Erythropoitin is a growth factor affecting erythroid progenitors and is produced by what organ?

Erythropoitin is a growth factor affecting erythroid progenitors and is produced by the kidney when it senses apoxia

Whenever hematopoiesis occurs outside the bone marrow in an adult , other than lymphopoiesis in lymphatic tissue it is called

Extramedullary hematopoiesis

Good dietary sources of iron include all except

Fruit does not contain iron

Where is the largest percentage of iron in the body located?

Hemoglobin

The following hemoglobin's are found in a normal human adult except

Hemoglobin gower-2

low white blood cell count

Leukopenia

What mechanism is responsible for the destruction of the majority of normal senescent erythrocytes?

Phagocytosis by macrophages in the spleen

Where is heme produced?

RBC precursors in the bone marrow

When compared with mature erythrocytes

Reticulocytes still contain some RNA

A test that is positive in all patients who have the disease but also in some who do not have the disease is

Sensitivity (diagnostic)

What is the most responsible for the strength and pliancy of the red blood cell membrane?

Spectrin

Heme is composed of iron and

Zinc protoporphyrin (ZPP) accumulates in red blood cells.

Where are surface markers that help in cell identification found?

cell membrane

Quality assurance

encompasses everything from the test order by the physician to the reporting of results to the correct patient chart

Glucose 6 phosphate dehydrogenase is

enzyme in the hexose monophosphate pathway and is important for maintaining reduced glutathione in the red cells

When hematopoiesis occurs in the liver in an adult it is called

extramedullary hematopoiesis

What important function does 2,3-BPG perform?

facilitates the delivery of oxygen to tissue

Select the condition where an acute increase in ferritin levels can be detected without a specific increase in the amount of systemic body iron?

infections, sequesters iron away from the bacteria

Heme synthesis takes place primarily in the

mitochondria

After birth, where does hematopoiesis predominately occur?

occurs in the bone marrow

Globin chains are synthesized

on the ribosomes in the cytoplasm of a developing RBC

Apoptosis is

programmed cell death.

Hemoglobin A is composed of

two pairs of unlike polypeptide chains, each of these chains containing one heme group