HHV: Human Herpes Virus (viral infection)
what viral infection is characterized by sore throat, fever, generalized lymphadenopathy, enlarged spleen, malaise, and fatigue, palatal petechiae?
(Epstein-Barr Virus) Infectioninfectious mononucleosis is characterized by sore throat, fever, generalized lymphadenopathy, enlarged spleen, malaise, and fatigue, palatal petechiae.
what is a Cytologic smear?
Cytologic smear-a thin tissue or blood sample spread on a glass slide and stained for cytologic examination and diagnosis under a microscope
what does Epstein-Barr Virus Infection hairy leukoplakia appear as in the oral cavity?
Epstein-Barr Virus Infection hairy leukoplakia appear as: - irregular, corrugated white lesion on the lateral border of the tongue
Epstein-Barr Virus Infection has 4 associated diseases: 1. 2. 3. 4
Epstein-Barr Virus Infection has 4 associated diseases: 1. infectious mononucleosis 2. hairy leukoplakia 3.. Nasopharyngeal carcinoma (rare neoplasm) 4. Burkitt lymphoma (rare neoplasm)
HAIRY LEUKOPLAKIA: CD (4 OR 8) helper t-cells- count goes down= hairy leukoplakia presents itself. This is a sign a patient is transitioning from _______ to __________
HAIRY LEUKOPLAKIA: CD4 helper t-cells- count goes down= hairy leukoplakia presents itself. This is a sign a patient is transitioning from HIV to AIDS
Hairy leukoplakia is commonly found in ___________ positive patients •Also found in immunocompromised patients NOT infected with _________-
Hairy leukoplakia is commonly found in HIV positive patients •Also found in immunocompromised patients NOT infected with HIV-
Herpes-zoster- Shingles diagnosis: treatment:
Herpes-zoster- Shingles diagnosis: -clinical appearance - cytologic smear treatment: - supportive care - antivirals may be given to immunecompromised patients - corticosteroids have been used for pain for postherpetic neuralgia
what viral infection appears as unilateral, painful eruptions of vesicles along the distribution of a sensory nerve?
Herpes-zoster- shingles appears as unilateral, painful eruptions of vesicles along the distribution of a sensory nerve
___________ is a form of chickenpox but in adults
Herpes-zoster- shingles is a form of chickenpox but in adults
what viral infection is associated with immunodeficiency or certain malignancies such as Hodgkin disease and leukemia
Herpes-zoster- shingles is a viral infection associated with immunodeficiency or certain malignancies such as Hodgkin disease and leukemia
-herpes complex Type 1 oral and Type 2 genital - varicella-zoster virus - Eipstein barr -Cytomegalo - Kaposi Sarcoma all follow under what kind of viral infection?
Human Herpes virus: -herpes complex Type 1 and Type 2 - varicella-zoster virus - Eipstein barr -Cytomegalo - Kaposi Sarcoma
what is the initial infection caused by the herpes simplex virus?
Primary Herpetic Gingivostomatitis
Primary Herpetic Gingivostomatitis oral appearance: -extremely painful - multiple tiny ______ on the perioral skin, _______ border of the lips and the oral mucosa - vesicles progress to form __________ - what color? - gingiva appearance? -bleeding?
Primary Herpetic Gingivostomatitis oral appearance: -extremely painful - multiple tiny vesicles on the perioral skin, vermillion border of the lips and the oral mucosa - vesicles progress to form ulcers - erythemic - gingiva appears swollen -bleeds easily
what are the symptoms of Primary herpetic gingivostomatitis?
Primary herpetic gingivostomatitis symptoms: -cervical lymphadenopathy - fever - malasie- general feeling of discomfort, illness or uneasiness - symptoms occur first then gingival and mucosal involvement
Primary herpetic gingivostomatitis: Most commonly occurs in children between _______ months- __________ years of age, though any person can get it who has not previously been exposed to the virus. - disease is self-______ -lesions will heal spontaneously in _____________ weeks
Primary herpetic gingivostomatitis: Most commonly occurs in children between 6 months- 6 years of age, though any person can get it who has not previously been exposed to the virus. - disease is self-limiting -lesions will heal spontaneously in 1-2 weeks
Prodromal symptoms (early signs) of recurrent HSV - - - (low or high) amount of viral properties (least or most) contagious
Prodromal symptoms (early signs) of recurrent HSV -pain - burning - tingling in area where vesicles are HIGH amount of viral properties MOST contagious DURING THIS STAGE
Recurrent herpes simplex infection transmission?
Recurrent HSV transmission: - direct contact with an infected person - can be transmitted to other areas - dont kiss babies
Recurrent HSV treatment
Recurrent HSV treatment: -Antiviral drugs •Acyclovir-used to treat genital herpes •No effective against labial herpes though wearing sunscreen on lips help -Topical antiviral agents •Lysine + •Abreva •Orajel cold sore treatment
Recurrent Herpes Simplex Infection appearance: -occurs on (non-ker or keratinized) mucosa? - commonly on the (soft/hard) palate and gingiva - painful clusters of tiny ______ or ulcers that can _______ to form a single ulcer with a (regular or irregular) border
Recurrent Herpes Simplex Infection appearance: -occurs on keratinized mucosa fixed to bone - commonly on the hard palate and gingiva - painful clusters of tiny vesicles or ulcers that can coalesce to form a single ulcer with a irregular border
are treatments for what viral infection? -Antiviral drugs •Acyclovir-used to treat genital herpes •No effective against labial herpes though wearing sunscreen on lips help -Topical antiviral agents •Lysine + •Abreva •Orajel cold sore treatment
Recurrent herpes simplex infection treatment: Antiviral drugs •Acyclovir-used to treat genital herpes •No effective against labial herpes though wearing sunscreen on lips help -Topical antiviral agents •Lysine + •Abreva •Orajel cold sore treatment
Recurrent herpes simplex infection: recurrence is produced by certain stimuli name some: - stress - - fatigue - - fever
Recurrent herpes simplex infection: recurrence is produced by certain stimuli name some: - stress - sunlight - fatigue - menstruation - fever
How is infectious mononucleosis transmitted?
Through saliva by direct oral contact with saliva - kissing
Varicella-zoster virus causes both ___________ (varicella) and ___________ (herpes zoster)
Varicella-zoster virus causes both chicken pox (varicella) and shingles (herpes zoster)
Varicella-zoster virus transmission: - ________________ - secretions from ________ - (low or high contagious)
Varicella-zoster virus transmission: - respiratory aerosols - secretions from skin lesions - HIGHLY CONTAGIOUS
chickenpox: symptoms include: -fever, headache and malaise •Generally occurs in children having only _____________episode in their lifetime •Oral lesions usually (do or don't) cause severe discomfort
chickenpox: symptoms include: -fever, headache and malaise •Generally occurs in children having only one episode in their lifetime •Oral lesions usually do not cause severe discomfort
chickenpox: •Incubation period = _______weeks •Recovery= ______weeks
chickenpox: •Incubation period = 2 weeks •Recovery= 2-3 weeks
true or false: hairy leukoplakia is seen primarily on the dorsal surface of the tongue
false: hairy leukoplakia is seen primarily on the LATERAL surface of the tongue
herpes-zooster- shingles Any branch of the trigeminal nerve can be affected: -Oral lesions occur when __________ branches are affected -Skin lesions on the forehead and around the eye occur when ___________ nerve is involved
herpes-zooster- shingles any branch of the trigeminal nerve can be affected: - oral lesions occur when the maxilarry and mandibular branches are affected -skin lesions on the forehead and around the eye occur when the ophthalmic nerve is involved
herpes-zooster-shingles •Prodromal symptoms: - ___________ -_____________ or both (paresthesia) precede the development of vesicles •Vesicles progress to _______- •Lasts for several weeks and in certain cases ______________ (Pain caused by damaged or irritated nerves) can take months to ______________
herpes-zooster-shingles •Prodromal symptoms: - pain -burning or both (paresthesia) precede the development of vesicles •Vesicles progress to ulcers •Lasts for several weeks and in certain cases neuralgia (Pain caused by damaged or irritated nerves) can take months to resolve
Herpetic whitlow is seen in what viral infection?
herpetic whitlow is a herpes simplex infection of the finger which can be caused by secondary or primary infection
infectious mononucleosis common in ___________ - self limiting and resolves in ______ weeks - •Multiple __________ occur in some patients -________
infectious mononucleosis common in young adults - self limiting and resolves in 4-6 weeks - •Multiple recurrences occur in some patients -benign
recurrent HSV diagnosis:
recurrent HSV diagnosis: - clinical appearance - cytologic smear - Tzanck cells - virally altered cells seen on a smear
chickenpox is _________ contagious causing ___________ and ____________ eruptions of the skin, mucous membranes
chickenpox is HIGHLY contagious causing vesicular and pustular eruptions of the skin, mucous membranes
after the initial infection, HHV will stay latent in the _______________causing a recurrent infection known as _________________ infection
after the initial infection, HHV will stay latent in the trigeminal ganglion causing recurrent infection known as recurrent herpes simplex infection
what happens after the initial infection of HHV?
after the initial infection, HHV will stay latent in the trigeminal ganglion causing recurrent infection known as recurrent herpes simplex infection
