Human Growth Hormone
Factors that increase HGH
Alpha-2 Stimulants Somatostatin Inhibitors Hypoglycemia Propranol (beta-blockers) Sleep, high intensity exercise, high protein intake (Low carbs)
Contraindications of HGH
Closed epiphyseal plates intracranial tumor Recent heart or abdominal surgery Diabetic retinopathy
Factors that decrease HGH
Corticosteroids Hyperglycemia (obesity) Somatostatin
Pharmacology of HGH
Facilitates protein synthesis Increases bone growth through proliferation and differentiation of osteoblasts Stimulates immune globulin, macrophage and lymphocyte synthesis Stimulates synthesis of cardiocytes Regulates lipometabolism
Human Growth Hormone
Hormone secreted by the anterior pituitary gland in response to growth hormone releasing hormone and is inhibited by secretion of growth hormone inhibiting hormone
Mode of uptake into the body
Injection only, oral will not survive the liver
MOA of HGH
Not fat soluble so: 1.) It binds to receptors activating the MAPK / ERK pathway which stimulates chondrocytes division of cartilage, or 2.) JAK-STAT signaling pathway
Who needs HGH
People with: Hypopituitarism Dwarfism Chronic renal insufficiency in children Short Barrel Syndrome