Human Growth Hormone

Factors that increase HGH

Alpha-2 Stimulants Somatostatin Inhibitors Hypoglycemia Propranol (beta-blockers) Sleep, high intensity exercise, high protein intake (Low carbs)

Contraindications of HGH

Closed epiphyseal plates intracranial tumor Recent heart or abdominal surgery Diabetic retinopathy

Factors that decrease HGH

Corticosteroids Hyperglycemia (obesity) Somatostatin

Pharmacology of HGH

Facilitates protein synthesis Increases bone growth through proliferation and differentiation of osteoblasts Stimulates immune globulin, macrophage and lymphocyte synthesis Stimulates synthesis of cardiocytes Regulates lipometabolism

Human Growth Hormone

Hormone secreted by the anterior pituitary gland in response to growth hormone releasing hormone and is inhibited by secretion of growth hormone inhibiting hormone

Mode of uptake into the body

Injection only, oral will not survive the liver

MOA of HGH

Not fat soluble so: 1.) It binds to receptors activating the MAPK / ERK pathway which stimulates chondrocytes division of cartilage, or 2.) JAK-STAT signaling pathway

Who needs HGH

People with: Hypopituitarism Dwarfism Chronic renal insufficiency in children Short Barrel Syndrome