Laboratory Animal Technician certification

15.Good Laboratory Practice (GLP) regulations are most likely to be mandated for which type of study? a. Food, drug, or environmental safety b. Cancer c. Genetic engineering d. Behavioral

15. a. Food, drug, or environ mental safety; p 24

16. What is an Animal Welfare Assurance? a. A protocol outlining how animals will be used in an experiment b. The law that mandates the United States Department of Agriculture to inspect animal facilities c. The mission statement for the Public Health Service d. An agreement from a research institution outlining how it complies with the Public Health Service Policy

16. d. An agreement from a research institution outlining how it complies with the Public Health Service Policy; p 17

20. Who is responsible for monitoring a study and ensuring compliance with Good Laboratory Practices (GLPs)? a. Primary investigator (PI) b. Institutional official (10) c. Quality assurance unit (QAU) d. Veterinarian

20. c. Quality assurance unit (QAU); p 24

28. Which organi:tation publishes the Guidelines on Euthanasia? a. United States Department of Agriculture (USDA) b. American Society of Laboratory Anima l Practitioners (ASLAP) c. American Veterinary Medical Association (AVMA) d. Association for Assessment of Laboratory Animal Care (AAALAC)

28. c. America n Veterinary Medical Association (AVMA); p 21

29. Which of the 3R Principles is addressed if non animal alternatives are used instead of animals? a. Refinement b. Replacement c. Reduction d. Restitution

29. b. Replacement; p 32

31. What is the general term for the policy at an institution that protects individuals from reprisal if they report a problem? a. WhistJeblower policy b. Compliance policy c. Institutional Animal Ca re and Use Committee (IACUC) protection policy d. Animal welfare policy

31. a. Whistleblower policy; p 33

32. What term refers to the concept that the way people behave is based on commonly held core valu es? a. Relevance b. Assurance c. Compliance d. Ethics

32. d. Ethics; p 31

33. According to the Guide, what is the term defined as the actions taken to assure that laboratory animals a re treated according to high ethical and scientific st andards? a. An imal ca re b. Anima l welfare c. Humane care d. Animal wellbeing

33. c. Humane care; p 31

34. When fewer an imals are used in a study, which of the 3Rs Principles is being applied? a. Replacement b. Reduction c. Refinement d. Regulation

34. b. Reduction; p 32

35. What term refers to knowing and following the rules? a. Compliance b. Protocol c. Ethics d. Assurance

35. a. Compliance; p 33

36. In the decision-making process, which step would come before gathering and accessing all the facts involved? a. Decide on .a course of action. b. Identify individuals and groups affected by the issue. c. Identify and evaluate possible solutions. d. Identify the issue of concern.

36. d. Identify the issue of concern; p 33

40. How long a re all Assurance records related to National Institutes of Health (N IH)-funded grants to be maintained? a. 1 year after completion of the study b. The duration of the experiment c. For the term of the grant d. At least 3 years after completion of the study

40. d. At least 3 years after completion of the study; p 36

13. According to the Guide, how often must the IACUC cond uct the facility inspections and program review? a. At least every 6 months b. At least once per year c. At least every 2 years d. At least every 3 years

13. b. At least once per year; p 18

14. 'Which animal is covered under the Animal Welfare Act (AWA)? a. Guinea pigs b. Poultry c. Birds d. Horses not used for research

14. a. Guinea pig; p 15

l. What is the primary federal granting agency through which the United States conducts and supports biomedical research? a. National Science Foundation ( NSF) b. National Institutes of Health (NI H) c. United States Department of Agriculture (USDA) d. Food and Drug Administration (FDA)

b. National Institutes of Health (NIH); p 11

12.What must an institution housing United States Department of Agriculture (USDA)-covered animals do annually as required by the Animal Welfare Regulations (AWR)? a. Submit a report b. Obtain a license c. Report the average daily animal census d. Submit health records for all housed animals

12. a. Subm i t a report; p 16

17. Which word is used in the Guide to describe aspects of an animal care program that are essential or imperative to the proper humane care and use of laboratory animals? a. Should b. Could c. Optional d. Must

17. d. Must; p 19

18. How often d oes the Association for Assessment and Accreditation of Laboratory Animal Care(AAALAC) perform site visits of accredited institutions? a. Once a year b. Every 2 years c. Every 3 years d. Every 5 years

18. c. 3 yea rs; p 27

19. What must a facility create and follow as required by Good Laboratory Practice (GLP) Regulations? a. Standard operating procedures (SOPs) b. Occupational health and safety program c. Disaster preparedness plan d. A mission statement

19. a. Standard operating proced ures (SOPs); p 25

21. Which animals below are covered under the Public Health Service (PHS) Policy? a. All vertebrate animals b. All invertebrate animals c. All vertebrates except mice d. All vertebrates and invertebrates

21. a. All vert ebrate animals; p 17

22. What is a requirement to maintain Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) accreditation? a. An inspection report from the United States Department of Agriculture (USDA ) b. An annual report by the institution that describes changes to the animal care and use program c. A $500 certification fee d. Proof of animal welfare training being offered every 6 months

22. b. An annual report by the institution that describes changes to the animal care and use program; p 27

23. What is the purpose of having standard operating procedures (SOPs)? a. To teach inspectors how a procedure is done b. To document that a procedure is being done c. To ensure uniformity in animal care d. To describe one of several ways a procedure is performed

23. c. To ensure uniformity in animal care; p 27

24. What is the correct name for the acronym AAALAC? a. American Association for Animal Laboratory Animal Council b. Association for Assessment and Accreditation of Laboratory Animal Care c. Association of American Animal Laboratory Administrators Committee d. Assessment and Accreditation Association for Laboratory Animal Care

24. b. Association for Assessment and Accreditation of Laboratory Animal Care; p 27

25. Which Un ited States Department of Agriculture (USDA) pain category would correspond with animals being bred, conditioned, or held for use in teaching, testin g, experiments, research, or surgery, but not yet used for such purposes? a. Category B b. Category C c. Category D d. Category E

25. a. Category B; p 16

26. Which United States Department of Agriculture (USDA) pain category would correspond with experiments, teach ing, research, experiments, or tests causing pain or distress to the ani mals, for which appropriate anesthetic, analgesic, or tranquilizing drugs were used? a. Category B b. Category C c. Category D d. Category E

26. c. Category D; p 16

27. What resource provides guidelines for programs that use agricultural animals for agricultural research or teaching? a. Guide for the Care and Use of Livestock b. Guide for the Care and Use of Farm Animals in Research c. Guide for the Care and Use of Agricultural Animals in Research and Teaching d. Guide for the Care and Use of Agricultural Animals in the Lab

27. c. Guide for the Care and Use of Agricultural Animals in Research and Teaching; p 21

30. "Which of the following is an example of the 3Rs Principle of replacement? a. Adding environmental enrichment to a cage b. Providing anesthesia after surgery c. Using computer models to provide data d. Using rats instead of mice

30. c. Using computer models to provide data; p 32

37. What is the a im of ethical decisions? a. For the needs of humans to be met b. For the needs to animals to be met c. For a balance of cost and benefits for humans an d animals d. For a balance of costs and benefits for researchers and the lACUC

37. c. For a balance of cost and benefits for humans and animals; p 33

38. When organizing your to-do list, how would you prioritize tasks? a. Smallest or quickest tasks first b. In order of importance and deadline demands c. Most time-consuming tasks first d. In order of preference

38. b. In order of importance and deadline demands; p 41

39. What is included in the health record for a nonhuman primate? a. Cage changes b. Feeding sched ule c. E nrichment activities d. Physical exams

39. d. Physical exams; p 36

41. Which is an example of a centralized management system? a. The main facility is run by one department and satellite facilities are run by the primary investigation group. b. Each department maintains its own facility. c. Expenditures and records involving animals are maintained by a separate department that serves all the institution's animal care needs. d. Each department is responsible for its own animal care staffi ng.

41. c. Expenditures and records involving a nimals are maintained by a separate department that serves all the institution's animal care needs; p 37

42. What is an example of a direct cost? a. Animals b. Maintenance c. Equipment depreciation d. Security

42. a. An i mals; p 37-38

43. Which expense is an example of an indirect cost? a. Bedding b. Animals c. Feed d. Telephone system

43. d. Telephone system; p 37-38

44. If each department within an institution maintains its own animal facility and operating budget, it is considered what type of management system? a. Centra lized b. Decentralized c. Indirect d. Direct

44. b. Decentralized; p 37

45. What is a cost center? a. An authorized vendor b. An activity that has expenses but does not directly produce revenue c. The department that manages the purchasing for a specific facility d. A budgeted amount for one department

45. b. An activity that has expenses but does not directly produce revenue; p 37

46. What should you do after you delegate a task? a. Leave the person alone and assume they know what they're doing. b. Go behind the person to make sure they did it right. c. Observe the person when they are doing the task. d. Follow up to be sure it has been completed.

46. d. Follow up to be sure it has been completed; p 41

47. Which of the following is important when working with co-workers? a. Listening b. Clear communication c. Conflict resolution d. All of the above

47. d. All of the above; p 41

48. Per diem costs are the expenses required to maintain one animal or one cage of animals for how long? a. I day b. 1 week c. 1 month d. 1 year

48. a. 1 day; p 38

49. If it costs S54,750 per year to maintain 100 rats, what would the per diem cost? a. $1.00 b. $1.50 c. $3.30 d. $5.47

49. b. $1.50; p 38. $54,750-:- 365 days/year + 100 rats= $1.50 per diem

50. Which item kept onsite requires a current Drug Enforcement Administration (DEA) license? a. Cleaners b. Toxic substances c. Anesthetics d. Con trolled substa nces

50. d. Controlled substances; p 37

2.What is an animal use protocol? a. A deta iled explanation of a research project involving animals b.The standard operating procedure for animal husbandry c.A request for money to finance animals used in a research project d. A description of all animals used in a facility over a 1 year period

a. A detailed explanation of a research project involving animals; p 12-1 3

11.What document must an institution have before the Public Health Service (PHS) will award a grant or contract that involves the use of animals? a.An approved Animal Welfare Assurance b. A quality assurance unit c. Standard operating procedures (SOPs) for every routine activity. D A health certificate from the United States Department of Agriculture (USDA)

a. An approved Animal Welfare Assurance; p 17

8. What is the name of the paperwork necessary to request research money? a. Grant application b. Animal use protocol c.Request for approval d.Principal investigator submission

a. Grant application; p 10

4.What is the purpose of the Institutional Animal Care and Use Committee's (IACUC's) protocol review? a. To ensure animal welfare and regulatory compliance b. To ascertain whether the protocol remains within budgetary guidelines c. To provide a mechanism for publishing the study results d. To assure that AAALAC accreditation is maintained

a. To ensure animal welfare and regulatory compliance; p 12

9.What documentation is required before an investigator can begin a study using animals? a. Association for Assessment and Accreditation of LaboratoryAnimalCare(AAALAC)accreditation b.Institutional Animal Care and Use Committee (IACUC) approval of the animal use protocol c. American Association for Laboratory Animal Science (AALAS) certification d.All of the above

b. Institutional Animal Care and Use Committee (lACUC) approval of the animal use protocol; p 12

10. Which feature must be provided for nonhuman primates as required by the Animal Welfare Act(AWA)? a. An exercise program b. Psychological enrichment c. Access to an outdoor area d. Structures for climbing

b. Psychological enrichment; p 15

5.Which statement regarding the post approval monitoring (PAM) program is TRUE? a. A post approval monitoring program is mandated by law. b. A post approval monitoring program is typically under the control of the attending veterinarian. c. A post approval monitoring program helps ensure that Institutional Animal Care and Use Committee (IACUC)-approved procedures are being followed. d. The staff of the post approval monitoring program decides what punitive actions are required if deficiencies are noted.

c. A post approval monitoring program helps ensure that Institutional Animal Care and Use Committee (lACUC)-approved procedures are being followed; p 13

7. What is the correct name for the acronym IACUC? a.Informational Animal Care and Use Committee b.Institutional Animal Care and Use Council cInstitutional Animal Care and Use Committee d.Institutional Annual Costs and Use Committee

c. Institutional Animal Care and Use Committee; p 12

3.What does the Institutional Animal Care and Use Committee (IACUC) do? a. Review animal use protocols b. Conduct inspections of animal facilities and reviews institutional animal use programs at least every 6 months c. Serve as an information and resource liaison on animal welfare and research concerns d. All of the above

d. All of the above; p 12

6.A systematic investigation to establish facts is the definition of what term? a. Hypothesis b. Protocol c. Data d. Research

d. Research; p 10