lipo protein
rate limitign enzmye in TAG synthsis-->!!!****
glyceol 3 phospahte acy ltrasferase inslin indicing
what indices LPL
inslin
glycerol goes where
liver
what happens to the reinat chylomicron where doe it go--> what has a recptr for it
liver
B100--> on
not HDL
after LPL acts on chylomicron waht is left over
"chylomicron reminet" this goes back to the "LIVER" !! APOe is on chylomicron remiaint
what will will act on the glyoceol in hte liver
"glycerol 3 phosphate dehydroginase" --> DHAP then depeinding if fed at starvation could go gluconeosis or krebs
what degrades chylomicirns i the systemi circation
"lipo protein lipase"
S/S-->
1. "turbid"--> inc VLDL 2. "creamy superant"--> foam in beacker 3. adomainl pain *******--> ** acutate pancrtisis"*** exam 4. eruptive xanthomas**** exam 5.lipemia ternia (rentna)
S/S-->
1. lipid malabsrobtion -essantal fatty acds and vitamins 2. low vit E --> lipid peroxidation--> ataxia bc attaks prepheral nerve (anemia) 3.rhabdomylsis
Nacent chylomicon matured n cirication after taking stuff from HDL what does it take from HDL
1.C2 2. E
types of lipo proteins
1.Chlyomicrons from intestine (exagius lipids) 2.VLDL from liver (endognius lipds MOSTLY not all) 3.IDL 4.LDL 5.HDL (smallest) (high desity)
famialaial LPL deeciy casues (3)
1.apo c2 defn 2.LPL denf 3.abnormal LPL
what apolipi proteins have "C2" (3)
1.chylomicron 2.VLDL 3. HDL
whatapolipi proteins caontain "Apo-E"
1.chylomicron remianint 2.IDL strange ones
3 fates of "IDL" (VLDL remiant)
1.liver APOE recptor + removes tags--> LDL (after give tag give back APO E) 2."hepatic lipase"--. APO E recptr--> rmeoves tags--> LDL 3. cholesterol ester trasfer protein (CETP)--> -"HDL" gives cholesterol--> IDL IDL gives TAGS to HDL LDL also taken up by liver = apob100 recptr
HDL has
APO "A1"--> steak souce bc helahty for you
once beomce chlyomicron remiaint after TAGS are removed waht goes back to the HDL
C2 Remiaint has APO E + B48
LPL binds to waht on chlyomicron
C2 APOc2
liver has repcotr for what on reminat
E Chymlomicron even though has apo E dosnt go into liver bc to big.
what vitamin is severly defecnt
E*****
what does HDL have
LCAT CEPT paroxanase (PON) LCAT=lecthitin trasferace CETP cholesterol ester transfer prptein
Abetalipoproteinemia--> what is hte problem
MTP not made trasfers lipied from SER to RER
VLDL nto blood what happens steps
Maturation--> APOc2 + APO E they get LPL acts on it--> FF into tisiue and glycerol to liver APOc2 goes back to --> HDL Now -->IDL
VLDL and chtlomicsons mostly contain waht type of fat
TAGS
***** exam VLDL is bigger than LDL but --> VLDL moves farther--> why
VLDL has buch more proteins (apoprotein B100"!!) has more negtive charge cathode to anode
"HDL" has what chylomiricrons
all but 48 +100
HDL
alpha alpha travels the fartherst
LDL
beta
LDL-->
choelsterol ester
abetalipo leads to dec in what
chylomcirons, VLDL,LDL + apoB (not detectable in blood)
waht lipoproteins contain -->vit ADEK rest have --> E ****
chylomicron remineint
what lpoprteins hace "B48"
chylomicron + reminent exogius source ones
VLDL
pre beta
HDL-->
proteins theregore highest density
