lipo protein

rate limitign enzmye in TAG synthsis-->!!!****

glyceol 3 phospahte acy ltrasferase inslin indicing

what indices LPL

inslin

glycerol goes where

liver

what happens to the reinat chylomicron where doe it go--> what has a recptr for it

liver

B100--> on

not HDL

after LPL acts on chylomicron waht is left over

"chylomicron reminet" this goes back to the "LIVER" !! APOe is on chylomicron remiaint

what will will act on the glyoceol in hte liver

"glycerol 3 phosphate dehydroginase" --> DHAP then depeinding if fed at starvation could go gluconeosis or krebs

what degrades chylomicirns i the systemi circation

"lipo protein lipase"

S/S-->

1. "turbid"--> inc VLDL 2. "creamy superant"--> foam in beacker 3. adomainl pain *******--> ** acutate pancrtisis"*** exam 4. eruptive xanthomas**** exam 5.lipemia ternia (rentna)

S/S-->

1. lipid malabsrobtion -essantal fatty acds and vitamins 2. low vit E --> lipid peroxidation--> ataxia bc attaks prepheral nerve (anemia) 3.rhabdomylsis

Nacent chylomicon matured n cirication after taking stuff from HDL what does it take from HDL

1.C2 2. E

types of lipo proteins

1.Chlyomicrons from intestine (exagius lipids) 2.VLDL from liver (endognius lipds MOSTLY not all) 3.IDL 4.LDL 5.HDL (smallest) (high desity)

famialaial LPL deeciy casues (3)

1.apo c2 defn 2.LPL denf 3.abnormal LPL

what apolipi proteins have "C2" (3)

1.chylomicron 2.VLDL 3. HDL

whatapolipi proteins caontain "Apo-E"

1.chylomicron remianint 2.IDL strange ones

3 fates of "IDL" (VLDL remiant)

1.liver APOE recptor + removes tags--> LDL (after give tag give back APO E) 2."hepatic lipase"--. APO E recptr--> rmeoves tags--> LDL 3. cholesterol ester trasfer protein (CETP)--> -"HDL" gives cholesterol--> IDL IDL gives TAGS to HDL LDL also taken up by liver = apob100 recptr

HDL has

APO "A1"--> steak souce bc helahty for you

once beomce chlyomicron remiaint after TAGS are removed waht goes back to the HDL

C2 Remiaint has APO E + B48

LPL binds to waht on chlyomicron

C2 APOc2

liver has repcotr for what on reminat

E Chymlomicron even though has apo E dosnt go into liver bc to big.

what vitamin is severly defecnt

E*****

what does HDL have

LCAT CEPT paroxanase (PON) LCAT=lecthitin trasferace CETP cholesterol ester transfer prptein

Abetalipoproteinemia--> what is hte problem

MTP not made trasfers lipied from SER to RER

VLDL nto blood what happens steps

Maturation--> APOc2 + APO E they get LPL acts on it--> FF into tisiue and glycerol to liver APOc2 goes back to --> HDL Now -->IDL

VLDL and chtlomicsons mostly contain waht type of fat

TAGS

***** exam VLDL is bigger than LDL but --> VLDL moves farther--> why

VLDL has buch more proteins (apoprotein B100"!!) has more negtive charge cathode to anode

"HDL" has what chylomiricrons

all but 48 +100

HDL

alpha alpha travels the fartherst

LDL

beta

LDL-->

choelsterol ester

abetalipo leads to dec in what

chylomcirons, VLDL,LDL + apoB (not detectable in blood)

waht lipoproteins contain -->vit ADEK rest have --> E ****

chylomicron remineint

what lpoprteins hace "B48"

chylomicron + reminent exogius source ones

VLDL

pre beta

HDL-->

proteins theregore highest density