Mutation: Sickle Cell Mutation

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What does sickle cell anemia cause?

DEFORMED RED BLOOD CELLS, ANEMIA and DAMAGE TO BLOOD VESSELS

Normal Hemoglobin

Produces normal blood cells - each red blood cell contains about 270 million Hemoglobin molecules - has flattened disc shape

mutant hemoglobin

Produces sickle- shaped red blood cells - less soluble and precipitates when deprived of oxygen - sickle cell disease

HBB gene

Hemoglobin beta gene that is mutated to cause sickle cell anemia - located on chromosome 11

The sickle cell disease involves...

The substitution of one base for another in the HBB gene, causing amino acids to be altered - new amino acid has different properties and causes hemoglobin to behave differently.

sickle cell anemia

is an inherited disoder caused by a gene mutation which codes for a faulty beta chain hemoglobin protein

hemoglobin molecule

is composed of two different types of protein subunits.

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