Mutation: Sickle Cell Mutation
What does sickle cell anemia cause?
DEFORMED RED BLOOD CELLS, ANEMIA and DAMAGE TO BLOOD VESSELS
Normal Hemoglobin
Produces normal blood cells - each red blood cell contains about 270 million Hemoglobin molecules - has flattened disc shape
mutant hemoglobin
Produces sickle- shaped red blood cells - less soluble and precipitates when deprived of oxygen - sickle cell disease
HBB gene
Hemoglobin beta gene that is mutated to cause sickle cell anemia - located on chromosome 11
The sickle cell disease involves...
The substitution of one base for another in the HBB gene, causing amino acids to be altered - new amino acid has different properties and causes hemoglobin to behave differently.
sickle cell anemia
is an inherited disoder caused by a gene mutation which codes for a faulty beta chain hemoglobin protein
hemoglobin molecule
is composed of two different types of protein subunits.