ORGMED- (BLUE PACOP)
5. Which of the following properties of matter is dependent on the quantity of matter present? A. Flammability B. Volume C. Boiling point D. reactivity E. density
B
55. The chemical reaction between an acid and a base that produces salt and water. A. Oxidation B. Reduction C. Neutralization D. Combination E. Single replacement
B
57. Acts as a blood coagulant in vivo and anticoagulant in vitro: A. Tartrate ion B. Citrate ion C. Phosphate ion D. Thiosulfate ion E. Sulfate ion
B
63. Itai-itai Disease is caused by poisoning with____. A. Mercury B. Cadmium C. Lead D. Iron E. Bismuth
B
64. Reagent that can differentiate carbonate form bicarbonate ion: A. 3 N Hydrochloric acid B. Phenolphthalein TS C. Hydrogen Sulfide D. Methyl Red TS
B
66. Official base that is pharmaceutical necessity for preparation of Aromatic Ammonia Spirit, NF: A. Sodium Carbonate, NF B. Strong Ammonia Solution, NF C. Potassium Hydroxide, NF D. Calcium Hydroxide Topical Solution, USP
B
7. Which of the following substances is pure? A. 5% dextrose B. Table sugar C. Blood D. rubbing alcohol E. salt solution
B
70. Reagent that can differentiate Potassium Alum Ammonium Alum: A. Aluminon reagent B. NaOH t,s, C. BaCl2 t,s, D. Dibasic Sodium phosphate E. Nitric acid
B
72. The precipitating reagent of Analytical Group I cations A. H2S B. HCI C. Na2CO3 D. H3PO4 E. Thioacetamide
B
75. Yellow brass is a combination of A. Cr and Ni B. Cu and Zn C. Ag and Cu D. Au and Cu E. Zn and Ni
B
77. Also known as the soluble group: A. Alkaline earth metals B. Alkali metals C. Coinage metals D. Halogens E. Chalcogens
B
79. The smallest particle of matter which enters to a chemical reaction. A. Molecule B. Atom C. compound D. element
B
82. Chromate in solution is colored: A. Orange-red B. Yellow C. blue D. yellow green
B
84. Fergon is: A. Ferrous lactate B. Ferrous gluconate C. ferrous sulfate D. ferrous fumarate
B
95. Rochelle salt is used as a/an: A. Antacid B. Saline cathartic C. Electrolyte replenisher D. antidiarrheal E. astringent
B
96. Zinc uranyl acetate, Mg uranyl acetate, cobalt uranyl acetate, forms insoluble salts with: A. Potassium B. Sodium C. Magnesium D. Calcium
B
98. The first element discovered by means of spectroscope: A. Rubidium B. Cesium C. Technutium D. None of these
B
For numbers 204-207, refer to the structure: HO 2 3 1 A 4 11 12 B 10 O D 15 16 13 9 E 5 14 N CH3 17 C H 6 8 7 HO Name this natural alkaloid A. Atropine B. Morphine C. Phenylpropanolamine D. Sphingosine
B
195. What makes this compound a prodrug? A. Its lack of intact sugar moiety B. its resemblance to the endogeonous C. The valyl ester functional group present D. its resemblance to the enzyme it Substrate it competes with inhibits
C
20. What is the maximum number of electrons that can be accommodated in the p subshell? A. 2 B. 5 C. 6 D. 10 E. 14
C
201. What is the expected of the pharmacokinetic property of this drug? A. It is hydrolyzed before it can reach the target receptor B. It enters the target cell through passive diffusion C. The quaternary nitrogen is responsible for its ease of excretion D. The amino group renders the drug pone to aromatic hydroxylation by the cytochrome oxidases
C
211. What is the color of the flame produced by halogen containing compounds in the flame test? A.Blue B.Yellow C. Green D. Orange
C
213. Found in the urine in the form of hippuric acid. A. Salicylic acid B. Methyl salicylate C. Benzoic acid D. Acetylsalicylic acid
C
223. The hybridization of Carbon in ethane is: A. sp B. sp2 C. sp3 D. sp4
C
224. A naturally occurring chelate essential in red blood cell-oxygen transport is: A. Insulin B. Hemoglobin C. Vitamin B12 D. Ascorbic acid oxidase
C
225. Which of the following statement/s is/are true regarding bioprecursor drugs? I. Antivirals are nucleoside analogs that undergo phosphorylation as a mechanism of activation II. Mechanism of activation involve redox & hydrolysis III. Proton pump inhibitors undergo chemical activation to bind H+ /K+ ATPase in parietal cells A.I, II & IV B.I. III & IV C.I & III D. II & IV E. II, III & IV
C
234. The use of this anti-ulcer agent has been limited due to its drug interactions & potential to cause problems in male patients taking them due to incidence of gynecomastia & impotence A.Pantoprazole B.Cimetidine C.Sucralfate D. Pirenzepine E. Misoprostol
C
236. The Tollen's reagent is used to identify functional group/s? I. Ketones II. Esters III. Aldehydes A.I only B.II only C.III only D. I and III E. I and II
C
238. Which of the statement regarding animes is not true? A. They can be primary, tertiary and secondar attached to the nitrogen atom B. animes undergo pyramidal inversion C. amines produce eracemic mixturesy depending on the number of substituents that can be resolved easily D. in synthesizing an amine, optical activity is not of assurance
C
For numbers 194-198, refer to the structure of valacylovir: O N NH2 NH N H3C O N NH2 CH3 O O 194. What functional group does this compound lack that causes the termination of growing DNA chain? A. 5' chloride atom B. 5' hydroxyl group C. 3' hydroxyl group D. 2' hydroxyl group
C
For numbers 199-203, refer to the structure of betanechol: H3C O H3C N+H2N O CH3 H3C
C
100. Cream of tartar is: A. potassium bitartrate B. sodium bitartrate C. potassium chloride D. sodium carbonate
A
101. Psom salt is synonymous to: A. Magnesium sulfate B. Calcium sulfate C. Aluminum sulfate D. Zinc sulfate
A
103. The cation/s that cause/s this group of antacid to have constipating property: A. Al+3 B. Mg+2 C. Ca+2 D. None of the given
A
11. Which of the following properties of elements decreases from left to right of the periodic table. A. Atomic size B. Electron affinity C. Electronegativity D. non-metallic property E. ionization potential
A
111. Phenol is soluble in: A. Oil B. Water C. Aqueous acids D. A and B E. A, B and C
A
118. The general formula CnH2nO can be assigned to a saturated_________. A. aldehyde B. alcohol C. ether D. carboxylic acid
A
12. Which of the following processes is a physical change? A. Distillation of water B. Digestion of food C. Neutralization of an acid by a base D. fermentation of coconut water E. combustion of methane
A
120. Carbinol is used as ending name of _____in the derived system of naming. A. alcohols B. phenol C. ethers D. esters
A
124. The following are unsaturated hydrocarbons, EXCEPT: A. alkane B. alkene C. 2-propanol D. B and C
A
131. Which of the following alcohols is unaffected by KMnO4? A. CH3OH B. CH3CH2OH C. (CH3)2 CHOH D. (CH3)3COH
A
132. Which of the following can be prepared from the dehydration of ethanol? A. ethylene B. ether C. ethanol D. A & B
A
135. Infant at birth is already capable of what metabolic reaction? A. sulfatation B. reduction-oxidation C.acetylation D. B & C
A
137. UDPGA is used in what type of phase II metabolic reaction? A. glucuronidation B. phosphorylation C. sulfatation D. glycine conjugation
A
140. Metabolism of mercaptopurine is inhibited upon administration of A. allopurinol B. aspirin C. MAOI D. phenytoin
A
144. Methenamine mandelate is a product of: A. molecular addition B. molecular replication C. molecular hybridization D. molecular disjunction
A
145. Which of the following is the target of antifungal agent, amphotericin B? A. Carbohydrate B. Lipid C. Protein D. Nucleic acid
A
148. Physicochemical property that have been studied by the QSAR approach which can be easily quantified for complete molecules? A. hydrophobic B. electronic C. steric D. AOTA
A
152. The E and C - clomiphene are examples of A. geometric isomers B. conformational isomers C. optical isomers D. position isomers
A
156. Which of the following is a sulfur containing antibiotic? A. Lincomycin B. Picromycin C. Vancomycin D. Polymixin B
A
157. B-blocker that is metabolized to napthoxylactic acid after oral dose is: A. Propanolol B. Pindolol C. TImolol D. Atenolol
A
16. The amount of heat requited to raise the temperature of one gram of a substance by one degree Celsius A. Specific heat B. Standard enthalpy C. Heat capacity D. heat of formation E. calorie
A
169. A species that loves a positive species is a: A. nucleophile B. electrophile C. free-radical D. none of the given
A
18. In reaction , nitrogen changes from the molecular state, N2 to NO2, what happened to nitrogen was: A. Oxidation B. Reduction C. Neutralization D. A and C E. B and CE. B and C
A
184. Which part of the molecule is responsible for poor oral absorption? A. Carboxylic acid group B. halogen C. Chorophenyl group D. Thio
A
198. How is this drug activated inside the body? A. Hydrolysis followed by triphosphorylation B. Cyclization of the acyclic sugar residue C. Removal of the sugar residue from the purine base D. 3' hydroxyl group triphosphorylation
A
203. Which is tru regarding the methyl group attached to the carbon beta to the quaternary nitrogen A.Confers selectivity of the drug to the B.It confers selectivity of the drug to the C. its removal would increase the muscarinic receptor stability of the drug against cholinesterases D. Replacement with a larger alkyl nicotinic receptor group would increase its activity
A
21. When a metal binds with a non-metal , the metal will most likely: A. Donate electron/s B. Accept electron/s unfilled orbitals C. Share its electrons D. allows its electron to move in an
A
210. Tollen's test is a test for: Pharmaceutical Chemistry A. Terminal alkynes B. Alkanes C. Non-terminal alkynes D. A, B and C
A
212. Aniline is liberated from acetanilide when treated with: A. HCl B. NaCl C. NaOH D. HNO3
A
214. The following compounds yield a violet color to FeCl3 test except: A. Benzoic acid B. Salicylic acid C. Methyl salicylate D. ASA
A
221. The oxidation of alkene with dilute KMno4 in cold base produce: A. Alcohol B. Ether C. Carboxylic acid D. ketone
A
230. When are mammalian cells chose as host cells for expression of the rDNA molecule? A.When the protein product requires a post B. When the paharmacist chooses to do so E. when the cloning vector is a Bacteriophage which does not havean origin of replication C. When high yields of the protein product is desired D. when the cloning vector is plasmid translational modification that other host cellsare in capable of doing so
A
231. Given the structure below, which of the following statement/s is/are true? CH2 -CH2 -NH2 I. Maximal Activity o fthis drug molecule is seen when the meta & para positions of the ring have hydroxyl groups II. Substitutions of the catechol ring with a resorcinol ring offers beta-1 selective agonist activity II. Bulky substituents on the amino group confers beta-2 selectivity A.I only B.I and II D. I and III C.III only E. I, II and III
A
244. ph is defined as the: A. negative log of the hydrogen ion B. log of the hydrogen ion concentration C. negative log of the ionization concentration constant D. sum of the hydrogen ion concentration and the hydroxyl ion concentration
A
249. According to the Bronsted Lowry theory, which of the following is untrue? A. strong acid give rise to a weak B. anions, cations and molecules may C. acids and bases react to form salts D. water can act either as an acidconjugate base or a base E. the ionization of an acid in show acidic or basic behavior water is an example of an acidbasereaction
A
25. Which of the following is a characteristic of the gaseous state? A. The molecules move past one another B. Is has definite shape C. The molecules are tightly bonded .D. its volume is definite E. All of the given
A
255. The principle that states that no two electrons in the same atom may have identical sets of all four quantum numbers A.Pauli's exclusion principle B.Hund's rule of maximum multiplicity C. Aufbau principle D. Schrodinger Theory
A
257. A molecular orbital in which electron density is low in the internuclear region. A. Antibonding molecular orbital B. Bonding molecular orbital C. Hybrid orbital D. None of the given
A
261. Nitric acid is an example of A. monoprotic B. diprotic C. polyprotic D. aprotic
A
263. Order of the reaction characterized by the equation Rate=k A.Zero B.First C. Second D. Third
A
265. Law of thermodynamics that states that energy can be converted from one for into another but it cannot be created or destroyed A. First Law B. Second Law C. Third Law D. none
A
269. Enantiomers differ from one another in A. Spatial configuration B. Rational formula C. ion-pair formation D. Photoelectric effect
A
278. These are local anti-infectives applied to ananimate objects. A. antiseptic B. disinfectant C.germicidal D. hand sanitizer
A
279. Gas sterilant A. ethylene oxide B. formaline C.glutaraldehyde D. phenol
A
281. Which of the following is not true about hexachlorophene USP? A. biphenol B. more potent than monophenol C. soluble in water D. adsorb on to the skin
A
282. Povidone is a ______ surfactant. A. non-ionic B. molecular C. ionic D.cationic
A
285. Methenamine is decomposed into______ at a urine pH of 5.5. This is responsible for methenamine's urinary tract antiseptic property A. formaldehyde B. carboxylic acid C. acetone D. ethanol
A
286. Sulfonamides are synthetic analogs of: A. PABA B. benzoic acid C. gentian violet D. methylene blue
A
289. 6-Methyl ether of erythromycin A. clarithromycin B. azithromycin C. dirithromycin D. lincomycin
A
291. Which of the following is a benzodiazepine? A. triazolam B. chloral hydrate C. amobarbita D. zolpidem
A
296. What is the pharmacological activity of the given drug? O H3C C O C OH A. Analgesic B. Sedative C. anti-bacterial D. hypnotic
A
297. This is a nucleus for_____: CH3 OH N(CH3)2 H H OH CONH2 OH OH O OH O A. Tetracycline B. Macrolide C. penicilin D. aminogycoside
A
298. What is the common name of methanol? A. Wood alcohol B. Spritus vini rectificatus C. cabolic acid D. NOTA
A
30. The ion that gives the Prussian blue precipitate with potassium ferrocyanide. A. Ferric B. Ferrous C. Zinc D. nickel E. cobalt
A
31. Evolves gas with fruity odow when treated with ethanol and concentrated hydrochloric acid A. Acetate B. Chlorate C. Sulfate D. silicate E. chromate
A
38. Salts are formed as result of the reaction between A. Acid and base B Water and metal D. Metal oxide and water D. non-metal oxide and water E. D and C
A
46. The empirical formula of diphosphorous pentoxide is: A. P2O5 B. PO2 C. PO3 D. PO E. P2O
A
50. Elements in the periodic table are arranged in order of increasing A. Atomic number B. Mass number C. Atomic weight D. atomic size E. All of the above
A
52. The law stating that elements combine in a fixed ratio by mass to form compounds. A. Law of Definite Proportion B. Law of Multiple Proportion C. Law of Thermodynamics D. Boyle's Law E. Charle's Law
A
56. A 10-volume hydrogen peroxide solution has a concentration of: A. 3% w/v B. 6% w/v C. 10% w/v D. 30% w/v E. 50% w/v
A
59. An official gas that is used in pharmaceutically to mask the disagreeable taste of certain medicines: A. Carbon Dioxide, USP B. Nitrogen, USP C. Helium, USP D. Oxygen, USP
A
6. An attraction of molecule by a magnetic field doe to completely paired electrons. A. Diamagnetism B. paramagnetism C. dia-para magnestism D. ferromagnetism E. none of the given
A
60. These are substances that take/absorb sufficient water from the atmosphere forming a liquid: A. Efflorescent B. Deliquescent C. A and B D. None of the choices
A
62. Ions found in the extracellular fluid EXCEPT: A. Phosphate B. Chloride C. Sodium D. Bicarbonate
A
69. This element is present in insulin A. Cr B. Cu C. Fe D. Al E. Ca
A
74. How many moles of aluminum reacts with sulfuric acid in this reaction Al + H2SO4 Al2SO4 + H2 A. 2 B. 3 C. 4 D. 5 E. 6
A
8. An atom with an atomic number of 15 and a mass number of 29 has _____neutrons A. 14 B. 15 C. 29 D. 39 E. 54
A
85. Mohr's salt is: A. Ferrous ammonium sulfate B. Ferrous potassium sulfate C. ferrous sulfate D. ferrous lactate
A
89. This is chronic lung condition resembling tuberculosis in symptoms: A. Silicosis B. Paraketosis C. Ketosis D. itai-itai disease E. Minamata Disease
A
91. A sulfur containing compound used as an antioxidant is: A. Sulfur Dioxide B. Sulfurated Potash C. Precipitated Sulfur D. Sulfur Dioxide E. Antimony Sulfide
A
93. Capsebon is used as : A. Anti-dandruff B. Keratolytic C. Scabicide D. fungicide E. anticariogenic
A
99. Laughing gas is a: A. General anesthetic B. Caustic C. disinfectant D. local anaesthetic
A
136. Metabolism of the following drugs result in more toxic product, EXCEPT: A. acetaminophen B. phenacetin C. sulfatation D. glycine conjugation
B
14. This refers to the direct transition of the solid state to the vapor state. A. Deposition B. sublimation C. evaporation D. condensation E. melting
B
141. Which of the following pairs is NOT classified as isosteres? A. N2 and CO B. O and CH C. F and OH D. NH2 and CH3
B
146. It is mathematical equation which relates a variety of physicochemical parameters to biological activities for a series of related structures. A. Hammett B. Hansch C. Craig plot D. Free-Wilson
B
150. Which of the following phase I metabolic reactions is involved in the conversion of Disulfiram to N, N -Diethylthiocarbamic acid? A. oxidation B. reduction C. hydrolysis D. dimethylation
B
161. Meta-hydroxy benzene is: A. catechol B. resorcinol C. aniline D. hydroquinone E. none of these
B
162. Methyl benzene is also known as: A. anisole B. toluene C. aniline D. catechol E. durene
B
163. 2-pentanol and 3-pentanol are: A. functional isomers B. positional isomers D. optical isomers C. chain isomers E. stereoisomers
B
167. Friedel Craft's acetylation of arenes forms: A. alkyl halides B. acyl halides C. carbonyl compounds D. neither a nor b
B
168. Elimination reaction leads to the formation of: A. saturated compound B. unsaturated compounds C. both a and b D. none of the given
B
170. Ozonolysis of alkenes forms: A. alkanes B. carbonyl compounds C. arenes D. amines
B
172. Markonikov addition of water to a double bond in a primary carbon results to the formation of: A. Primary alcohols B. Secondary alcohol C. alkanes D. tertiary alcohols
B
177. Predict the major product of the following reaction: Br2 light ? Br Br A. C B. Br D. BrBr
B
178. The ring in an aromatic compound typically undergoes what type of reaction A. addition B. substitution C. eliminatio D. Oxidation-reduction
B
186. This part of the molecule confers further strain to the beta-lactam ring. A. Acylamino side chain B. Bicylic ring system C. Chlorophenyl methyl Isoxazalidine D. Carboxylic acid
B
19. How many moles of sodium are in a mole of sodium thiosulfate? A. 1 B. 2 C. 3 D. 4 E. 5
B
192. Which part of molecule can be replaced with a more electron-withdrawing functional group to stabilize the ionic form of the drug? Pharmaceutical Chemistry A. Sulphonamide moelty B. Thiazole moiety C. Para-amino group D. Isoxazole moiety
B
193. What is the major biotransformation reaction that this drug undergoes? A. Hydrazine formation B. N-acetylation C. Hydrolysis D. hydrolysis
B
197. What functional groups are responsible for good oral absorption of this drug? A. Adenine residue B. Valine ester C. 3' hydroxyl group D. 5' hydroxyl group
B
2. This is radioactive particle that weights almost the same as helium atom. A. x-ray B. alpha ray C. gamma ray D. beta ray E. ultraviolet ray
B
205. Whichis true about substitution of the 6-OH group? A. Its removal increases the activity B. Its acetylation increases addictive property C. Its methylation decreases analgesic D. Its methylation result to increase in Polarity
B
206. What is expected of the pharmacokinetic property is of this drug? A. It is easily hydrolyzed B. It passes through the blood brain barrier C. The unprotonated tertiary nitrogen accounts for its ease of excretion D. Its sulphate salt is stored in adipse more readily than the N-dealylated analogue tissues
B
207. Which is true about the substitution of phenolic -OH group? A. Its removal increases the analgesic property B. Methylation removes the analgesic property of the drug when administered intracerebrally C. Acetylation decreases the chance D. Increasing the electron density by adding electron withdrawing substituents at C-1 position inactivates the drug
B
208. Which part of the molecule is not required for analgesis? A. Ring A B. Ether bridge C. Nitrogen atom D. C7-C8 double bond
B
209. The following organic compounds give positive result to Lassaigne's test EXCEPT: A. Nitriles B. Amides C. Thiols D. Amines
B
216. Methyl salicylate is prepared from the reaction of salicylic acid and: A. NAOH B. CH3OH C. CH3OCCOOH D. CH3OCH3
B
219. Carbon in organic compounds is analyzed as carbon dioxide using: A. Lime water B. Soda lime C. Cuprous oxide D. Lead acetate
B
22. This states that orbitals of the same energy will be singly filled first with electrons before they are paired. A. Aufbau principle B. Hund's rule C. Pauli's Exclusion Principle. D. Heisenberg Uncertainly Principle E. n + I rule
B
220. Hat gas can be prepared from the acid catalyzed dehydration of athanol? A. Methane B. Ethene C. Ethyne D. None of the given
B
47. Which of the following pairs of atoms will most likely form an ionic bond A. C and O B. C and Ca C. C and Cl D. C and H E. C and S
B
49. This refers to ability of an atom to attract electrons of another atom to its side. A. Ionization potential B. Electronegativity C. Electron affinity D. diamagnetism E. paramagnetism
B
105. Nessler's reagent is used to identify: A. K+ B. NH4+ C. Na+ D. Al3+
D
106. Used for bone imaging. A. Technetium 99m-phytate B. Technetium 99m-heptagluconate C. Technetium 99 HIDA D. technetium 99 Etidronate
D
110. The oxidation state of a carbon atom is equal to the number of: I. C-X bonds IV. C-O bonds II.C-H bonds V. C-S bonds III. C-N bonds A. II, III and IV B. II, IV and V C. I, II and III D. I, III and IV E. I, II and V
D
115. What is the common name of tetrametheylmethane? A. 1opentane B. 2opentane C. 3o pentane D. neopentane
D
119. Derivative of carboxylic acid which is formed from the removal of one molecule of water in two RCOOH. A. ester B. acid halide C. acid amide D. acid anhydride
D
125. Which of the following is not true about organic compounds? A. they are more soluble in B. mostly covalent compounds C. generally less stable to heat non-polar solvents. D. only produced by living organisms
D
129. Which of the following benzene ring substituents can act as meta directors? A.-Cl B. -OH C. -CH3 D. -COOH
D
139. The following are drugs that can induce auto-induction, EXCEPT A. phenobarbital B. phenylbutazone C. probenecid D. alcohol
D
143. As of the present, it is the most used and productive method of obtaining new drugs. A. random screening B. extraction from natural sources C. serendipity D. molecular manipulation
D
15. the reaction of a metal chloride dioxide produces: A. metal chlorite B. metal carbide C. metal oxide D. metal chlorate E. metal perchlorate
D
151. Which among the following penicillins contain phenolic R group? A. Pen G B. Pen V C. Ampicillin D. Amoxicillin
D
164. The chemical CH3CH2COOCH3 is given an IUPAC name of: A. 3-butanone B. propanoic acid C. ethylmethyl ether D. methyl propanoate E. butanal
D
166. Acetylenes refer to: A. alkanes B. alkenes C. aromatic hydrocarbons D. alkynes
D
17. In a family, the topmost element has the smallest: A. Electronegativity B. Ionization potential C. Electron affinity D. atomic size E. a and b
D
173. p-hydroxy phenol is also known as: A. creso B. resorcinol C. catechol D. hydroquinone
D
180. Which of the following combinations of reagents is appropriate to brominates the ring of benzene as shown below?. Br A. Br2, light B. Br2. H2O C. Br2, H2SO4 D. Br2, FeBr3
D
191. Which of the following functional group-intermolecular bonding pairs is applicable to the drug-target interaction of the compound? A. Sulphonamide - Hydrogen bonding B. Amino-ionic bonding C. Amino-covalent bonding D. Benzene ring - van der WaalsBonding
D
196. What the part renders this drug recognizable by the viral thymidylate kinase? A. Valine residue B. Adenine residue C. 3' hydroxyl group D. Guanosine residue
D
200. What part of the molecule gives the electronic stability against cholisnesterases? A. The methylene bridge B. The ester bond C. The quaternary nitrogen D. the primary amino group of Urethane
D
202. What part of the molecule serves as bioisostere of the acetyl group of the acetylcholine in terms of binding to the receptor? A.The metylene bridge B. The quaternary nitrogen C. The N-methyl groups D. The primary amino group of urethane
D
215. Saponification is an alkali hydrolysis of A. RCOR B. ROH C. RCOH D. RCOOR
D
217. Acetophenone undergo nucleophilic substitution with -OH in the presence of: A. NaClO4 B. NaClO3 C. NaClO2 D. NaClO
D
218. This is employed for the purification of organic compounds which partially or completely decompose before their normal boiling points are reached. A.Steam distillation B.Simple distillation C. Fractional distillation D. Vacuum distillation
D
222. This undergoes hydrolysis in the presence of heat producing phosgene. A. CH3Cl B. CH2Cl2 C. CH4 D. CCl4
D
232. Given the molecule below: Which of the following statemenst/s is/are true? I. The amine groups must be tertiary for optimum activity II. Substitution in the para position is essential for selective beta 1 Antagonistic activity III. Substituents on the amino group must be bulky A.I only B.I and III C.III only D. II and III E. I, II and III
D
233. Which of the following antihistamines is now commonly used as an appetite stimulant due to its CNS depressant properties? A.Meclizine B.Cylcizine C.Buclizine D. Chlrocyclizine E. Hydrozyzine
D
24. The reaction NiCl2 + Zn -------- Ni + ZnCl2 is a _______type of reaction A. Combination B. Combustion C. Decomposition D. single replacement E. metathesis
D
254. Elements that have atomic numbers from 58 t0 71 and appears at the bottom of the chart are called: A. metals B. non-metals C. actinides D. lanthanides
D
26. Graphite is an allotrope of the element______. A. Na B. Pb C. Ca. D. C E. O
D
267. A process in which high molecular weight hydrocarbons are broken down into lower molecular weight compounds. This process is used in petroleum refining. A.Bergius process B.Haber process C. Steam reformer process D. Cracking
D
27. This is also known as the salt-forming group of elements A. Chalcogens B. Alkali metals C. Alkaline earth metals D. halogens E. colnage metals
D
28. A substance which can act as either an acid or a base. A. Polymorph B. Deliquescent C. Amorphous D. amphoteric E. none of the given
D
36. These are atoms of the same element having the same protons but of different number of neutrons. A. Isobars B. Isotones C. Isomers D. isotopes E. none of the given
D
40. This grouping of elements in the periodic table is based on the number of main energy levels filled by the electrons. A. Family B. Group C. Period D. A and B E. B and C
D
43. This class of matter exhibits electrical property and optical property known as Tyndall effect. A. Solution B. Suspension C. Emulsion D. colloid E. compound
D
51. These are electron pair donors. A. Bronsted Lowry acids B. Arrhenius bases C. Lewis acids D. Lewis Bases E. Arrhenius acids
D
53. Number of valence electrons of the element with atomic number 12. A. 8 B. 6 C. 4 D. 2 E. 1
D
61. What is the chemical name of HCIO3? A. Hydrochloric Acid B. Hypochlorous Acid C. Chlorous Acid D. Chloric Acid
D
71. Plaster of Paris is chemically known as: A. CaO B. CaSO4 C. CaSo4 2H2O D. CaSO4 1⁄2 H2O E. CaSo4 1 1⁄2 H2O
D
76. In this reaction : Al + Fe2O3 -----> Al2O3 + Fe Which of the substances from the above reaction was reduced? A. Al B. Fe2O3 C. Al2O3 D. Fe
D
86. Chalybeate water contains: A. Lithium B. Carbon C. salt D. iron
D
88. Three Bromides Elixir contains bromides of: I. Na II.Ca III.K IV.NH4 V.Fe A. I, II and III B. II, III and IV C. III, IV and V D. I, III and IV E. I, IV and V\
D
9. Two electrons occupying the same orbital differ in their: A. Principal quantum number B. Azimuthal quantum number C. Magnetic quantum number number D. spin quantum number E. angular momentum quantum
D
92. Topical Zirconium preparations have been employed: I. As antiperspirants II. For its specific action against uroshiol III. To remove warts A. I, II & III B. I & II C. II & III D. I & III E.I only
D
97. Borates in turmeric paper is colored: A. Olive B. Green C. White D. Reddish brown
D
Which of the following statements shows an extensive property? A. Iron nails conduct heat B. Sampaguita flowers smells sweet C. Water boils at 100 0C D. A pinch of sugars weighs 2.3 grams E. Glycerin is viscous
D
45. Metals can be coiled in wires because they are A. Malleable B. Ductile C. Lustrous D. brittle E. good conductors
B
121. The suffix used in IUPAC system naming of acid halide is: A. -yl B. -oyl C. -oate D. -oxy
B
126. Ethylene oxide, a gaseous sterilizer, belongs to: A. ester B. ether C. alcohol D. phenol
B
128. 1, 3-butadiene is classified as: A. allenic B. conjugated C. non-conjugated D. A & C
B
133. The reaction of ROH + RCOOH is called: A. neutralization B. esterification C. dehydration D. oxidation
B
10. What particles account for most of the mass of an atom? A. Proton B. Electron C. Neutron D. a and b E. a and c
B
102. Compound responsible for the pink color of Calamine USP 24: A. Talc B. Zinc oxide C. Zinc steatate D. Ferric oxide
B
104. Elements that are found as diatomic molecules include all except : A. Oxygen B. Nitrogen C. Flourine D. Sulfur E. Hydrogen
B
107. A mixture containing 30% ZnS and 70% BaS: A. Copperas B. Lithopone C. Hausemonite D. Braunite
B
108. Protonic concept of acidity: A. Arrhenius B. Bronsted-Lowry C. Lewis D. none of the given
B
109. Which of the following is a yellow sulfide? A. PbS B. CoS C. ZnS D. CdS
B
112. The property of a chemical agent to destroy one form of life without harming another. A. Chemotherapy B. Selective toxicity C. Antimicrobial activity D. sterilization E. pasteurization
B
116. The type of carbon which is NOT present in 2, 2, 3-trimethyl butaneis: A. Primary B. Secondary C. tertiary D. neo
B
117. Vinyl is a/an_________radical. A. alkyl B. alkenyl C. talkynyL D. benzyl
B
229. Which of the following statement/s is/are true? I. Endonucleases may make their cut within DNA molecules, so as to form stickyrends which d not readily anneal or revert back to the parent double stranded DNA molecule II. When blunt ends are formed after a cut an endonuclease, these two strands are difficult to anneal or to revert back to the parent double stranded DNA molecule III. The gene to be inserted into a cloning vector is attached with a gene enconding for antibiotic resitance for ease of isolation & selection of cells that have acquired the rDNA molecule A.I & II B.II & III D. I only E. II only C. I, II & III
B
23. The formula that gives the actual number of atoms is A. Structural B. Molecular formula C. Empirical formula D. chemical formula E. none of the given
B
235. Primary alcohols, on oxidation, gives carboxylic acids but the oxidative reaction can be stopped after producing the aldehyde from the primary alcohol by using what oxidizing agent? A. KMnO4 B. H2CrO4 C. PCC D. THF E. DIBAH
B
237. The nitrogen heterocycle depicted below is: O CH3 H3C N N N N CH3 A.Nicotine B.Caffeine C.Diazepam D. Purine E. Quinoline
B
239. The common name of the heterocycle given below is: N H A.Pyridine B.Piperidine C. Pyrrole D. Pyrrolidine E. Cyclohexane
B
240. What is the reaction depicted below and what is its significance? O CH2 P CH2 + H3C CH2-C-CH2CH3 H3C CH2-C-CH2CH3 A.Michael Addition; best way to produce tertiary carbonyl group B.Wittig Reaction; best way to produce tertiary E. Aldol Reaction; a good means of Alkenes since it is very redioselective C. Phosphorylation; many biomolecules areactivated by phosphorylation D. Reduction of Ketones; good for carbonyl group synthesizing hydrocarbons from thedeoxygenation
B
241. What is IUPAC name of the molecule given below? O O H3C C C CH2 O A. Acetic benzoic anhydride B. Benzoic propanoic anhydride C. 1-phenyl-1,2-butan-dione D. Propyl benzoate E. 1-phenyl-1,2 -dioxobutane
B
243. For a week acid, when the pH of the solution is the same as that of the pKa of the acid, the percentage of ionization of the acid will be: A.25% B.50% C. 75% D. 100%
B
250. Aluminum oxide, Al203 has a molecular weight of 102. What is its equivalent weight? A.17 B.34 C. 51 D. 102
B
251. He discovered radioactivity A. Rutherford B. Bequerel C. Chadwick D. None of the given
B
256. The quantum number that identifies the orientation of the orbital within the subshell. A. Principal B. Magnetic C. Azimuthal D. Spin
B
258. It states that when conditions are changed, a system in equilibrium reacts in a way that tends to counteract the change. A. Henry's law B. Le Chatelie's Principle C. Raoult's law D. None of the given
B
260. Oxides of metals are A. acidic B. basic C. neutral D. depends on the metal
B
262. Order of reaction characterized by the equation Rate # k [A] [B] A.First order B.Second order C Third order D. First order
B
264.Will a precipitate of Mg(OH)2 form in a 0.00010 M solution of Mg (NO3)2 if the pH of the solution is adjusted to 9.0? The Ksp of Mg (OH)2 is 8.9 x 10-12 A. yes B. no C. maybe D. insufficient
B
266. A process, run at high pressures, at high temperatures and in the presence of a catalyst in which hydrogen and nitrogen react to produce ammnonia A. Bergius process B. Haber process C. Steam reformer process D. All of the given
B
271. Esters are formed by the reaction between: A. Acids and bases B. Acids and alcohols C. Acid and aldehydes D. Acids and ketones E. aldehydes and bases
B
273. Molecular geometry of the boron trifluoride A. linear B. trigonal planar C.tetrahedral D. trigonal bipyramidal E. octahedral
B
274. The law that states that at constant pressure and temperature, the volume of a gas is directly proportional to the number of moles of the gas present. A.Boyle's Law B. Avogadro's Law C.Gay Lussac's Law D. Ideal Gas Law E. Charle's Law
B
275. A solid solution of either of two or more nonmetals A. amalgam B. alloy C. ore D. None of the given
B
276. The equation that tells the possible energy states of an electron in hydrogen atom and the probability of its location in a particular region A. Plank's equation B. Schrodinger equation C. de Broglie equation D. Bohr equation
B
277. Claisen Condensation reactions involve what carbonyl compounds? A. esters and ketones B. aldehydes and ketones C. two aldehydes D. two esters E. two ketones
B
284. Used to disinfect drinking water: A. copper sulfate B. halazone C. chloroform D. muriatic acid
B
288. The first compound in the development of a drug that has the desired biological and physiological properties. A. prodrug B. lead drug C. latent drug D. linker
B
29. Most abundant and essential of all elements A. aluminum B. oxygen C. silicon .D. carbon E. Hydrogen
B
300. Live attenuated virus. A.Toxoid B. Vaccine C. immunoglobulin D. antitoxin
B
32. Rochelle salt which is used as a cathartic and also as sequestering agent is: A. KHC4H4O6 B. KNaC4H4O6 C. KSbC4H4O6 D. Na2C4H4O6 E. K2C4H4O6
B
39. Atoms that are tightly bound together and behave as a single entity A. Molecule B. Ion C. Element D. mixture E. none of the give
B
4. A mole of a substance: A. Contains Avogadro's number particles B. Weighs the same as its atomic weight or molecular weight expressed in grams C. Contains the same number of particles as 12 grams of Carbon D. A and B E. All of the above
B
41. When an atom accepts an electron it forms a/an A. Cation B. Anion C. Neutrally charged entity D. A and B E. none of the given
B
1. The water ion theory of acids and bases is attributed to: A.Lewis B.Bronsted C.Arrhenius D. Pauling E. Pearson
C
114. What is the general formula give to alkalines? A. CnH2n B. CnH2n+1 C. CnH2n+2 D. C2H2n-2
C
122. The molecular formula C7H12 can be a/an: A. alkane B. alkene C. alkyne D. aromatic
C
123. Which of the following can be considered isomer of n-propanol? A. acetone B. methoxymethane C. 2-propanol D. B and C
C
127. The simplest ketone is: A. methanone B. ethanone C. propanone D. butanone
C
130. Grignard reagent (RMgX) is not stable in: A. ether B. THF C. water D. A & B only
C
134. The following functional groups can be found in Eugenol, EXCEPT: A. -OH B. -O- C. =C= D. -CH2-CH=CH2
C
138. Morphine is an active metabolite of: A. atropine B. cocaine C. codeine D. barbital
C
142. The type of molecular modification applied in the conversion of B-phenylproplonic acid (inactive) to cis-cinanamic acid (active)? A. Ring opening B. Formation of higher homolog C,introduction of double bond D. introduction of chiral center
C
147. Semi-synthetic procedure used in producing 6-aminopenicillanic acid is by hydrolyzing Pen G or Pen V using enzyme penicillin______. A. esterase B. penicillinase C. acylase D. hydrolase
C
149. Which of the following hormones will not undergo hydrolytic reaction? A. human insulin B. growth hormone C. sex hormones D. parathyroid hormone
C
153. Antibody (Ab) found in persons with allergies of various types, as well as in autoimmune diseases. A. IgM B. IgA C. IgE D. IgD
C
154. A solution of antibodies derived from the serum of animals immunized with specific antigens. A. vaccine B. toxoid C. immune globulin D. antotoxin
C
155. This is used in the treatmesn of Gaucher's disease. A. Interferons B. Interleukin C. cerezyme D. monoclonal antibody
C
158. Propanone and 1-propen-1-ol are considered: A. Positional isomers B. Configurational isomers C.tautomers D. enantiomers E.chain isomers
C
159. What is the general term that is used to refer to compounds having two hydroxyl groups attached to two adjacent carbons? A. Carbinol B. catechol C. glycol D. glycerol
C
165. A carbon with four different moieties attached to it is generally called: A. anomeric carbon B. epimeric carbon C. stereocenter D. carbonyl carbon
C
171. Which of the following alcohols is most reactive to Lucas reagent? A. n-butanol B. iso-butyl alcohol C. tert-butyl alcohol D. methanol
C
174. Potassium sorbate (structure shown below) is a preservative commonly used in pharmaceuticals. The group markedwith dashed lines is an example of a(an): H3C O - K + A. Isolated diene B. Cumulated diene C. conjugated diene D. cyclic diene
C
175. BHT or butylated hydroxytoulene (structure shown below) is an antioxidant employed to retard oxidative degradation of oils and fats in various cosmetics and pharmaceuticals. The common name of the branched substituent marked with dashed lines is: CH3 OH CH3 H3C-----C C---CH3 CH3 CH3 CH3 A. Neobutyl- B. Isobutyl- C. tert-butyl D. n-butyl
C
176. Which of the following reactions would be classified as propagation? Pharmaceutical Chemistry A. CH3 + Br -> CH3Br r B. Br 2Br C. CH3 + Br2 -> CH3Br + B D. CH3 + CH3 CH3CH3
C
185. Part of the molecule that renders it inactive agaist Gram negative bacteria. A.Thiazole ring B. Halogen C. Chlorophenyl methyl Isoxazolidine moiety D. The beta-lactam ring
C
187. Part of the molecule that is always present but not essential for activity A. Acylamino side chain B. Bicyclic ring system C. Sulphur atom D. Primary amino group
C
188. Name the general group of compound A. Beta lactamases B. Lincosamides C. Penicillins D. Chloramphenicols
C
189. This part of the molecule that should not be substituted unless the compound is intended as a prodrug A. Sulphonamide moeity B. Thiazole moiety C. Para- amino group D. Isoxazole moiety
C
190. This drug is an antimetabolite for what endogenous compound? A. Adenosine monophosphate B. Omega- 3 fatty acids C. Topoisomerase I D. Para-amino benzoic acid
C
245. Which of the following statements is untrue? A. ionization and dissociation are synonymous B. pKa is the negative log of the ionization C. pH is the log of the reciprocal of the hydrogenIon concentration D. pKa is only applicable to water as the solvent E. In solvents having a low dielectric Constatant constant, dissociation may be slight
C
246. The water ion theory of acids and bases is attributed to: A. Lewis B. Bronsted D. Pearson E. Pauling C. Arrhenius
C
248. In which of the following concepts is the formation of a coordinate covalent bond a consequence? I. Water-Proton Theory II. Theory of Solvent Systems III. Bronsted Lowry Theory IV. Lewis Theory A.I & III B.I & IV C. IV D. III & IV E. II
C
252. Type of radiation which consists of streams of electrons that travel 0.4 times the speed of light A.Alpha B.Beta C. Gamma D. None of the given
C
253. The law that states that when two elements A and B form more than one compound, the amounts of A that are combined in these compounds with a fixed amount of B are in small whole number ratio. A.Law of Conservation of Mass B.Law of definite Proportion C. Law of Multiple Proportion D. None of the given
C
259. What is the oxidation number of Cr in the dichromate ion Cr2O7 -2 ? A. +5 B. -5 C. +6 D. -6
C
268. Which of the following forms of radiation is the most penetrating? A. alpha B. beta C. gamma D. positron
C
270. A compound having an asymmetric carbon exhibits A. chair boat isomerism B. cis-trans isomerism C. optical isomerism D. A and B E. A, B and C
C
272. The distance between the nuclei of two covalently bonded atoms in a molecule A. Atomic radius B. Atomic diameter C. Bond length D. Bond distance E. None of the given
C
280. It is also known as methyl rosaniline chloride A. methylen blue B. gentian violet C. Carbol fuchsin D. bromo cresol green
C
283. In phenols, substitution at______ position increases bacterial activity. A. ortho B. meta C. para D. A and B
C
287. This structure is essential for the antibacterial property of penicillins and cephalosporins: A. 6-aminopenicillanic acid B. dihydrothiazine C. beta-lactam ring D. sulfamoyl group
C
290. These are composed of two amino sugars linked together in glycosidic linkage to a central hexose A. penicilins B. aminoglycoside C. macrolides D. tetracyclines
C
292. Which of the following is a dissociative anesthetic? A. morphine B. fentanyl C. ketamine D. lidocaine
C
299. Which of the following is not a phenol derivative? A.Cresol B.Eugenol C. chlorhexidene D. thymol
C
3. This is a sulfur containing ion that does not react with sulfuric acid? A. Sulfide B. Sulfite C. Sulphate D. thiosulfate E. all of the given
C
33. The most electronegative element in the periodic table is: A. S B. Cl C. F D. O E. N
C
35. The state of matter which occur only at temperatures near absolute zero. A. Plasma B. Solid C. Bose condensa'es D. Liquid E. Gas
C
42. Substances that completely ionize in water are A. Non-electrolytes B. Weak electrolytes C. Strong electrolytes D. Molecular E. Covalent
C
44. The product produced from the reaction of a non-metal oxide and water. A. Base B. Salt C. Oxy acid D. Binary acid E. none of the given
C
48. The percentage of C in sugar ( C12H22O11) if the atomic weight of C=12, H=1 and O=16 is A. 3.5% B. 8.3% C. 42.1% D. 57.9% E. 85%
C
54. The sum of atomic masses of all the atoms in a molecule or formula unit. A. Atomic mass B. Molar mass C. Molecular mass D. empirical mass E. none of the given
C
58. Synonym for Ammonium Carbonate, NF: A. Spirit of Hartshorn B. Sal Ammoniac C. Preston Salt D. Spirit of Mindererus E. None of the given
C
65. The following are regarded as soft acids according to HSAB concept EXCEPT A. Ag+ B. Hg+2 C. Al+3 D. none of the above
C
67. Official preparations of Potassium: I. Potassium Chloride in Sodium Chloride Injection , USP II. Potassium Chloride Oral Solution, USP III. Potassium Chloride Effervescent Tablets for Oral Solution, USP IV. Potassium Chloride in Dextrose Injection, USP A. I, II, and III B. II, III and IV C. I, II, and IV D. I, II, III and IV
C
68. Systematic acidifiers: I. Monabasic Sodium Phosphate, USP II. Potassium Citrate, USP III. Ammonium Chloride, USP A. I and II B. II only C. I and III D. II and III
C
73. Products of sodium chlorate decomposition. A. NaO + H2 B. Na2O + HCl C. NaCl + O2 D. None
C
80. Hard water does not lather in with soap. This is due to: A. K B. Al and O C. Mg and Ca D. Zn and Pb
C
81. Pink appearance A. Copper B. Nickel C. Cobalt(III) D. Chromium(III)
C
87. Magnesium is detected using the dyestuff_______ in alkaline solution forming a blue lake: A. Aluminum reagent B. Amaranth C. p-nitrobenzene resorcinol D. oxime reagent
C
90. Precipitated sulfur is used as a/an: A. Bactericidal B. Anti-viral C. Scabicide D. antioxidant E. cathartic
C
94. Which of the following maybe seen in patients on Bismuth containing products as antacids and antibacterial? A. Rebound hyperacidity B. Achloryhdria C. Black stools D. Neurological distubances E. Luminous vomitus
C
113. Anti-bacterial potencies of primary alcohols increase with molecular weight up to____ only. A. C3 B. C4 C. C5 D.C6 E. C8
E
160. Which of the following substrates can be used to synthesize tertiary alcohols? A. formaldehyde B. ethanol C. propanone D. ethane E. none of these
E
242. The compound below belongs to what type of organic compounds? NH A.Lactones B.Amides C.Cyclic Carbonyl Compounds D. Carboxamides E. Lactams
E
247. An aqueous solution of the following acids is prepared. Which will be the strongest acid? A. HCl B. HNO3 C.HClO4 D. Sulfuric Acid E. none, all are the same strength
E
34. Which of the ff. scientists is/are the author/s of the periodic law? A. Dalton B. Proust C. Charles and Boyle D. De Broglie E. Meyer and Mendeleev
E
37. Produced by filling an orbital by an electron which is not removed from its atom but is held mutually or share by 2 atoms concerned. A. Ionic bond B. Van der Waal's C. Hydrogen bond D. metallic bond E. covalent
E
78. Calcium imparts a _______________color to a non-luminous flame. A. Crimson red B. Carmine red C. Bright yellow D. green E. brick red
E
83. Stainless steel is an alloy containing the following elements EXCEPT: A. Fe B. C C. Cr D. Ni E. Pb
E
