PATH - Wound Healing

What do you lose with healing by secondary intention?

Adnexa

What is healing by second intention?

Infarction, inflammatory ulceration, abscess formation, surface wounds with large defects. More intense inflammatory reaction Formation of a very large amount of granulation tissue Wound contraction

What does the histological section overleaf show?

Skin wound/sacr showing the result of healing by secondary intention. Notice the margin that clearly demarkates the collagenous scar.

What is healing by first intention?

Wounds with opposed edges - usually only seen in surgery.

What are the six steps of wound healing?

a)induction of acute inflammatory process [due to initial injury] b) regeneration of parenchymal cells c) migration and proliferation of parenchymal and connective tissue cells d) ECM synthesis e) remodelling of connective tissue and parenchymal components f) collagenisation and acquisition of wound strength