Phagocytosis Steps

Step 1:

chemotaxis and adherence of microbe to phagocyte

Step 5:

digestion of ingested microbe by enzymes

Step 7:

discharge of waste materials

Step 3:

formation of a phagosome

Step 6:

formation of residual body containing indigestible material

Discharge

fuses to membrane and releases waste

Step 4:

fusion of the phagosome with a lysosome to form a phagolysosome

Residual body formation

indigestible material left over

Step 2:

ingestion of microbe by phagocyte

Phagocytosis

ingestion of microbes or particles by a cell (phagocyte) -phagocytes are all forms of WBC's

Ingestion

phagocyte extends pseudopods to engulf cell -once pseudopods meet and fuse, they form a phagosome

Chemotaxis

phagocytes attracted to microbes -damaged cell pieces, cytokines, pieces of microbial cells, etc.

Digestion

phagosome fuses to lysosome and creates a phagolysosome -lysozyme, oxygen radicals, lipases, proteases, RNase, DNase

Adherence

toll-like receptors attach to PAMPs -phagocyte releases cytokines to recruit other phagocytes