Pharmaceutics 2 exam 2- quiz questions

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Which of the following capsules sizes has the largest capacity? A. 5 B. 000 C. 0 D. 1 E. 4

B. 000

A pharmacist receives a prescription for 15 mg piroxicam capsules, qty. 48. A #1 capsule filled with piroxicam weighs 245 mg; a capsule filled with lactose weighs 180 mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra). A. None of the above B. 750 mg piroxicam + 8.45g lactose C. 750 mg piroxicam + 9.00 g lactose D. 15 mg piroxicam + 165 mg lactose E. 15 mg piroxicam + 230 mg lactose

B. 750 mg piroxicam + 8.45g lactose

What is the role or function of Hydroxy Propyl Methyl Cellulose (HPMC) in the following tablet coating formulation: HMPC, 5 cps, 7.5% w/w PEG, 0.8 %w/w Iron oxide yellow: 0.6% w/w Titanium dioxide: 3.1 %w/w Purified water: 88% w/w A. Opacifier B. Main coating material/polymer C. Plasticizer/pore forming agent D. Solvent or vehicle E. Pigment or colorant

B. Main coating material/polymer

Drug is compressed into tablets with a slowly soluble polymer A. ion-exchange B. Matrix dissolution C. Matrix diffusion D. Osmotic pumping

B. Matrix dissolution

The respective amount of zinc oxide and cocoa butter required to make these 12 suppositories is: A. ZnO: 6 grams Cocoa butter: 2.3 grams B. ZnO: 3.6 grams Cocoa butter: 23 grams C. ZnO: 36 grams Cocoa butter: 23 grams D. ZnO: 0.36 grams Cocoa butter: 2.3 grams E. ZnO: 3.6 grams Cocoa butter: 24 grams

B. ZnO: 3.6 grams Cocoa butter: 23 grams

Considering this "secret" formula and procedure, the amount of Acetaminophen (in kg) required to produce 1 million tylenol tablets is: A. 5 kg B. 50 kg C. 500 kg D. 0.5kg E. 500,000kg

C. 500 kg

Drug is compressed into tablets with an insoluble polymer A. ion-exchange B. Matrix dissolution C. Matrix diffusion D. Osmotic pumping

C. Matrix diffusion

Hydroxychloroquine (PlaquenilÒ) is considered a disease-modifying anti-rheumatic drug (DMARD). It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine may also be used to treat coronavirus (COVID-19) in certain hospitalized patients. Description: Active pharmaceutical ingredient (API): The molecular weight of hydroxychloroquine sulfate is 433.95, and molecular formula is C18H26ClN3O.H2SO4. PLAQUENIL (hydroxychloroquine sulfate) tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Inactive Ingredients: Dibasic calcium phosphate USP, hypromellose USP, magnesium stearate NF, polyethylene glycol 400 NF, polysorbate 80 NF, corn starch, titanium dioxide USP, carnauba wax NF, shellac NF, black iron oxide NF. In this formula magnesium stearate is used as: A. Binder B. Filler or diluent C. Disintegrant D. Opacifier E. Lubricant

E. Lubricant

Advantages to the manufacturer for tablet film coating when compared to sugar coating include: I shorter production times II less gross weight III lower incidence in coat chipping A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct

E. if I, II, and III are correct

Dry binder examples

Cellulose, methyl cellulose, PVP, PEG

Gildant examples

Silica, magnesium stearate, talc

If the API of 125 mg tablet decays by zero-order kinetics with a reaction rate constant kinetic of 0.5 mg per hour, what is the amount of intact drug remaining after 3 days (72 hours)? A. 89 mg B. 8.9 mg C. 0.89 mg D. 890 mg

A. 89 mg

Which of the following statements is NOT TRUE about modified-release drug products? A. Advising patients to drink a full glass of alcohol with these medications for better absorption B. Advising patients not chew on these products during administration C. Delayed release products are not bioequivalent to Extended release product for the same active ingredient. D. Advising patients not to crush these products to maintain their physical integrity E. They are commercially available in various solid dosage forms: ER tablets or Capsules

A. Advising patients to drink a full glass of alcohol with these medications for better absorption

You are asked to prepare 2 sets of twelve 1g suppositories, Set A and Set B. Set A requires 12 suppositories each containing 50mg of Drug X while Set B requires both 50mg of Drug X as well as 300mg of Drug Y in all twelve suppositories. Cocoa butter or Theobroma oil will be used for the base of the suppositories. A) What quantity of theobroma oil base is required in each set? B) How much does an individual suppository weigh in each set? Note: Displacement values of X and Y are 0.7 and 1.5, respectively. Hint: Make 15 suppo. to account for losses. A. Solution A) Theobroma oil for set A = 13.9g , for set B =10.9g and Solution B) Individual suppo in Set A = 0.98g and in set B = 1.08g B. Solution A) Theobroma oil for set A = 0.98g , for set B =1.08g and Solution B) Individual suppo in Set A = 13.9g and in set B = 10.9g C. Solution A) Theobroma oil for set A = 10.9g , for set B =13.9g and Solution B) Individual suppo in Set A = 0.98g and in set B = 1.08g D. Solution A) Theobroma oil for set A = 13.9g , for set B =10.9g and Solution B) Individual suppo in Set A = 1.08g and in set B = 0.98g

A. Solution A) Theobroma oil for set A = 13.9g , for set B =10.9g and Solution B) Individual suppo in Set A = 0.98g and in set B = 1.08g

The shells of soft gelatin capsules may be made elastic or plastic by the addition of? A. Sorbitol B. Povidone C. HPMC D. Polyethylene glycol

A. Sorbitol

Drug is bound to a resin and released due to changes in pH A. ion-exchange B. Matrix diffusion C. Matrix diffusion D. Osmotic pumping

A. ion-exchange

What is the role or function of iron oxide yellow in the following tablet coating formulation: HMPC, 5 cps, 7.5% w/w PEG, 0.8 %w/w Iron oxide yellow: 0.6% w/w Titanium dioxide: 3.1 %w/w Purified water: 88% w/w A. Vehicle or solvent B. Colorant C. Opacifier D. Plasticizer/pore forming agent E. Main coating material/polymer

B. Colorant

Agents that might be used to coat enteric-coated tablets include: I hydroxypropyl methylcellulose (HPMC) II carboxymethylcellulose (CMC) III cellulose acetate phtalate (CAP) A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct

B. if III only is correct

Most commercial vaginal suppository use a base of: A. beewax B. polyethylene glycol C. glycerin D. cocoa butter E. glycerinated gelatin

B. polyethylene glycol

The rectal route of administration of drug may be preferred over the oral route for some systemic-action because A. inert binders, diluents, and excipients cannot interfere with absorption B. absorption is predictable and complete C. a portion of the absorbed drug does not pass through the liver before entering the systemic circulation D. the dissolution process is avoided. E. the drug does not have to be absorbed

C. a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

High bloom strength gelatin is used in the manufacturing of? I. Soft gelatin capsules II. Hard gelatin capsules III. None of the above A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct

C. if I and II are correct

Drug is compressed into tablets with semipermeable membrane and laser drilled hole through which drug is transported out by convective flow A. ion-exchange B. Matrix dissolution C. Matrix diffusion D. Osmotic pumping

D. Osmotic pumping

What is the role or function of purified water in the following tablet coating formulation: HMPC, 5 cps, 7.5% w/w PEG, 0.8 %w/w Iron oxide yellow: 0.6% w/w Titanium dioxide: 3.1 %w/w Purified water: 88% w/w A. Main coating material/polymer B. Colorant or pigment C. Opacifier D. Vehicle or solvent E. Pore forming agent/plasticizer

D. Vehicle or solvent

A satisfactory suppository base must meet all of the following criteria EXCEPT A. it should have a narrow melting range B. it should dissolve or disintegrate rapidly in the body cavity C. it should be nonirritating and nonsensitizing D. it should melt below 30ºC E. it should be inert

D. it should melt below 30ºC

The following steps involved in hard gelatin capsule shells production? I. Dipping II. Spinning III. Trimming A. if I only is correct B. if III only is correct C. if I and II are correct D. if II and III are correct E. if I, II, and III are correct

E. if I, II, and III are correct

Glidants

Facilitate flow of granules from hopper

Solution binder examples

Gelatin, PVP, cellulose derivatives, HPMC, PEG, sucrose and starch

Fillers

Increase size and weight if final dosage form

Filler examples

Lactose, sucrose, glucose, mannitol, sorbitol, calcium phosphate, calcium carbonate and cellulose

Lubricant examples

Magnesium stearate, stearic acid, polyethylene glycol, sodium lauryl sulphate, sodium stearyl funarate, liquid paraffin

Antiadherent examples

Magnesium stearate, talc; starch, cellulose

Antiadherent

Prevent sticking to die and punch

Solution binders

Primate particle aggregation/cohesion in liquid state

Disintegrants

Promote break down of particle aggregates

Dry binders

Promote particle aggregation in solid state

Lubricants

Reduce interactions/fri ruin between particle and surface of processing equipment

Disintegrants examples

Starch, cellulose, PVP, sodium starch glycolate, sodium carboxymethyl cellulose

True statements, about the function of excipients used in tablet formulations include: I binders promote granulation during the wet granulation process. II glidants help to promote the flow of the tablet granulation during manufacture. III lubricants help the patient to swallow the tablets. if I and II are correct if III only is correct if II and III are correct if I, II, and III are correct if I only is correct

if I and II are correct

Manufacturing variables that would likely affect the dissolution of a prednisone tablet in the body include: I the amount and type of binder added II the amount and type of disintegrant added III the force of compression used during tableting if III only is correct if I and II are correct if I, II, and III are correct if II and III are correct if I only is correct

if I, II, and III are correct


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