Pharmacology: Aspirin
Aspirin prevents the formation of __________ A2 which would cause platelets to aggregate and arteries to constrict.
thromboxane
Aspirin Interactions
warfarin (Coumadin) may potentiate the effects of aspirin
Aspirin Contraindications
-Hypersensitivity -History of GI bleeding or ulcers -Known bleeding disorders -Acute asthma
Aspirin Precautions
-Patients taking warfarin or other anticoagulants -Renal or hepatic disease or failure (decreases renal blood flow) -Hypersensitivity to other NSAIDs -Asthmatic patients (may increase viscosity of respiratory secretions and cause mucous plug formation)
Aspirin Dosage
325 mg (4 chewable 81 mg tablets)
Aspirin Onset & Duration
5 - 10 minutes; 1- 4 hours (24 hours for anticoagulant effect)
Aspirin Indications
Acute myocardial infarction or myocardial ischemia
Aspirin Classification (4)
Antiplatelet Anti-inflammatory (NSAID) Antipyretic Analgesic
Salicylate Toxicity Symptoms
Hyperventilation, agitation, confusion, drowsiness, lethargy, behavioral changes, sweating, and constipation
Aspirin Mechanism of Action
Impedes clotting and prolongs bleeding by blocking platelet aggregation by slowing prostaglandin synthesis action, which also impedes inflammation response.
Aspirin Routes of Administration
PO
Aspirin Side Effects
Prolonged bleeding, GI bleeding, epigastric pain, heartburn, N/V