Pharmacology: Aspirin

Aspirin prevents the formation of __________ A2 which would cause platelets to aggregate and arteries to constrict.

thromboxane

Aspirin Interactions

warfarin (Coumadin) may potentiate the effects of aspirin

Aspirin Contraindications

-Hypersensitivity -History of GI bleeding or ulcers -Known bleeding disorders -Acute asthma

Aspirin Precautions

-Patients taking warfarin or other anticoagulants -Renal or hepatic disease or failure (decreases renal blood flow) -Hypersensitivity to other NSAIDs -Asthmatic patients (may increase viscosity of respiratory secretions and cause mucous plug formation)

Aspirin Dosage

325 mg (4 chewable 81 mg tablets)

Aspirin Onset & Duration

5 - 10 minutes; 1- 4 hours (24 hours for anticoagulant effect)

Aspirin Indications

Acute myocardial infarction or myocardial ischemia

Aspirin Classification (4)

Antiplatelet Anti-inflammatory (NSAID) Antipyretic Analgesic

Salicylate Toxicity Symptoms

Hyperventilation, agitation, confusion, drowsiness, lethargy, behavioral changes, sweating, and constipation

Aspirin Mechanism of Action

Impedes clotting and prolongs bleeding by blocking platelet aggregation by slowing prostaglandin synthesis action, which also impedes inflammation response.

Aspirin Routes of Administration

PO

Aspirin Side Effects

Prolonged bleeding, GI bleeding, epigastric pain, heartburn, N/V