Physiology CHP 15 MC

Which of the following statements regarding hormonal regulation of gastrointestinal function is TRUE? A. An increase of H+ in the small intestine stimulates secretion of the hormone secretin, which in turn stimulates HCO3- secretion by the pancreas. B. The presence of fatty acids in the stomach stimulates secretion of CCK, which in turn stimulates enzyme secretion by cells in the antrum of the stomach. C. The presence of amino acids in the small intestine stimulates secretion of gastrin, which in turn stimulates HCl secretion by parietal cells. D. The presence of fatty acids in the small intestine stimulates the secretion of the hormone secretin, which causes contraction of the gallbladder. E. The hormone somatostatin stimulates the secretion of H+ into the lumen of the stomach.

A. An increase of H+ in the small intestine stimulates secretion of the hormone secretin, which in turn stimulates HCO3- secretion by the pancreas.

Which is TRUE regarding the secretion of HCl in the stomach? A. H+ is actively transported into the gastric lumen by ATPase pumps in the mucosal membrane. B. H+ is actively cotransported into the lumen by secondary active transporters coupled to K+. C. The pH of the blood leaving the area of the parietal cells is lower than the normal ECF value of 7.4. D. H+ diffuses passively from mucosal epithelial cells into the lumen of the stomach, following Cl-. E. Cl- and HCO3- are exchanged across the luminal membrane of epithelial cells via a passive transport protein.

A. H+ is actively transported into the gastric lumen by ATPase pumps in the mucosal membrane.

Which is TRUE regarding the three phases of the control of HCl secretion? A. In the intestinal phase, an increase in osmolarity of the contents of the duodenum decreases HCl secretion. B. In the gastric phase, distension of the stomach decreases HCl secretion. C. In the cephalic phase, increased nutrient concentration in the duodenum stimulates HCl secretion. D. In the intestinal phase, increased peptide concentration in the stomach inhibits HCl secretion. E. In the gastric phase, decreased H+ concentration in the stomach inhibits HCl secretion.

A. In the intestinal phase, an increase in osmolarity of the contents of the duodenum decreases HCl secretion.

Which of the following statements regarding neural regulation of gastrointestinal function is TRUE? A. Networks of neurons in the wall of the GI tract innervate the wall's smooth muscle. B. Smooth muscle of the GI tract is innervated by both sympathetic and somatic motor nerves. C. If the autonomic nerves to the GI tract were cut, digestion and absorption of food could no longer take place. D. The nerve plexus of the GI tract exists in a single layer, just outside of the serosa. E. There are no afferent neuronal pathways from the GI tract to the central nervous system.

A. Networks of neurons in the wall of the GI tract innervate the wall's smooth muscle.

2. Which is TRUE about gastric motility? A. The basic electrical rhythm of the gastric smooth muscle (three depolarizations per minute) is the same regardless of whether or not food is present. B. Gastric contractions are strongest in the fundus of the stomach. C. The force of contraction is decreased by gastrin and increased by enterogastrones. D. When a wave of excitation reaches the pyloric sphincter, action potentials become inhibitory and the sphincter opens wide to allow chyme to exit. E. The term "slow waves" refer to gastric contractions, while "pacemaker" refers to gastric action potentials.

A. The basic electrical rhythm of the gastric smooth muscle (three depolarizations per minute) is the same regardless of whether or not food is present.

Which of the following statements regarding lipid digestion and absorption is TRUE? A. The presence of fatty acids in the duodenum stimulates the secretion of CCK, which in turn stimulates secretion of pancreatic enzymes. B. The presence of fatty acids in the duodenum stimulates the secretion of secretin, which in turn stimulates contraction of the gallbladder. C. The presence of fatty acids in the duodenum stimulates the secretion of gastrin, which in turn stimulates bile synthesis in the gallbladder. D. The presence of fatty acids in the duodenum stimulates emptying of the stomach. E. The presence of fatty acids in the stomach stimulates the secretion of secretin, which inhibits motility of the large intestine.

A. The presence of fatty acids in the duodenum stimulates the secretion of CCK, which in turn stimulates secretion of pancreatic enzymes.

Which of the following is NOT true about gallstones? A. They cause lactose intolerance. B. They cause pain. C. They cause impaired fat digestion. D. They cause general nutritional deficiencies. E. They cause jaundice.

A. They cause lactose intolerance.

Which of the following is the most potent inhibitor (directly or indirectly) of gastric motility and emptying? A. fat in the duodenum B. acid in the stomach C. carbohydrate in the stomach D. gastrin E. distension of the stomach

A. fat in the duodenum

Lactose intolerance: A. is an inability to digest milk sugar. B. is most common in very young children. C. results from the inability to secrete insulin. D. results from removal of the gallbladder. E. is an inability to digest proteins.

A. is an inability to digest milk sugar.

Which of the following is secreted by the chief cells of the gastric mucosa? A. pepsinogen B. HCl C. intrinsic factor D. gastrin E. pepsin

A. pepsinogen

The primary kind of motility in the stomach during digestion of a meal is: A. peristalsis. B. segmentation. C. relaxation of the pyloric sphincter. D. mass movement. E. regurgitation.

A. peristalsis.

The type of smooth muscle contraction occurring in the esophagus during swallowing is called: A. peristalsis. B. mass movement. C. segmentation. D. distension. E. eccentric.

A. peristalsis.

Which of the following would be most likely to cause metabolic alkalosis? A. severe vomiting B. severe diarrhea C. hyperventilation D. strenuous exercise E. hypoventilation

A. severe vomiting

Which of the following statements regarding protein digestion and absorption is TRUE? A. Only the exocrine pancreas produces enzymes that can digest proteins. B. After absorption, the products of protein digestion are carried by blood directly to the liver. C. Pepsin digests protein mainly in the small intestine. D. The enzymes that digest protein are secreted in active form. E. Free amino acids are the only product of protein digestion that can be absorbed from the lumen into intestinal epithelial cells.

B. After absorption, the products of protein digestion are carried by blood directly to the liver.

Which occurs during the secretion of hydrochloric acid by gastric epithelial cells? A. There is a decrease in the pH of blood in the hepatic portal circulation. B. Bicarbonate ions are secreted into the hepatic portal circulation. C. Chloride ions are pumped from the cytosol of the gastric epithelial cells into the hepatic portal circulation blood. D. Both H+ and K+ are actively pumped from the epithelial cell cytosol into the lumen of the stomach. E. Vesicles containing H+/K+ -ATP-ase proteins are endocytosed into vesicles within the gastric epithelial cells.

B. Bicarbonate ions are secreted into the hepatic portal circulation.

Which of the following statements about the transport of the absorbed products of fat digestion is TRUE? A. Free fatty acids and monoglycerides are transported to the liver via the hepatic portal vein. B. Products of fat digestion first go to the lymph system, and then to the veins leading to the heart. C. Triglycerides are transported to the liver via the hepatic portal vein to be processed. D. Free fatty acids and monoglycerides are assembled into triglycerides before they are absorbed from the lumen of the gut into epithelial cells lining the tract. E. Products of fat digestion are absorbed in the distal portion of the ileum, bound to intrinsic factor.

B. Products of fat digestion first go to the lymph system, and then to the veins leading to the heart.

A person without a gallbladder: A. cannot secrete bile. B. cannot store bile. C. will have no difficulty digesting a large, fat-rich meal. D. cannot digest fats. E. cannot store lipase.

B. cannot store bile.

Regurgitation of food from the stomach into the esophagus: A. is ordinarily inhibited by the upper esophageal sphincter. B. causes irritation of the esophageal mucosa. C. is called retropulsion, and is essential for gastric digestion. D. is ordinarily prevented by the pyloric sphincter. E. is called secondary peristalsis.

B. causes irritation of the esophageal mucosa.

Which of the following processes is NOT associated with gastrointestinal function? A. digestion B. filtration C. secretion D. motility E. absorption

B. filtration

Which of the following breakfasts would likely remain in the stomach longest? A. toast, orange juice, and coffee B. fried eggs, bacon, and hash browns C. a bowl of cereal with skim milk D. a boiled egg, toast, and juice E. The type of meal has no effect on the rate of gastric emptying.

B. fried eggs, bacon, and hash browns

The exact causes of inflammatory bowel diseases continue to be explored, but it is relatively clear that: A. it is equally common among people of all ages and racial groups within the population. B. it is likely to result from a combination of environmental and genetic factors. C. individuals suffering from its effects are largely experiencing the consequences of the absence of immune mechanisms in the gastrointestinal tract. D. it can be easily diagnosed since its symptoms are always very specific and the affected areas are always limited to a very focused area within the small intestine. E. the cause is allergy to a single particular food, and patients get immediate relief by simply not eating that food.

B. it is likely to result from a combination of environmental and genetic factors.

Which of the following is NOT characteristic of inflammatory bowel disease (IBD)? A. bleeding, edema, and ulceration anywhere along the gastrointestinal tract B. pain relief when changing to a diet higher in fiber C. perforations in the mucosa and intestinal wall, leading to infection by bacteria, which are normally present and benign D. inflammation and thickening of the bowel wall to the point of preventing the usual passage of feces E. pain in the lower right abdomen frequently mistaken for appendicitis

B. pain relief when changing to a diet higher in fiber

What structure secretes the enzyme that breaks down starch to smaller carbohydrates? A. the esophagus B. pancreatic exocrine cells C. pancreatic duct cells D. the liver E. the large intestine

B. pancreatic exocrine cells

The primary kind of motility in the small intestine during digestion of a meal is: A. peristalsis. B. segmentation. C. receptive relaxation. D. migrating motility complex. E. mass movement.

B. segmentation.

Which of the following would be most likely to cause metabolic acidosis? A. severe vomiting B. severe diarrhea C. hyperventilation D. hypoventilation E. traveling to high altitude

B. severe diarrhea

Which of the following statements regarding digestion and absorption of carbohydrates is TRUE? A. Carbohydrate digestion begins in the stomach. B. Lactose intolerance results from an insufficiency of the enzyme amylase. C. Digestible polysaccharides are broken down into the monosaccharides glucose, galactose, and fructose, which can be absorbed. D. Sucrose is the main form of carbohydrate that can be absorbed by active transport across the intestinal epithelium. E. Cellulose from plants is a polymer of glucose that can be easily digested and absorbed by the human GI tract.

C. Digestible polysaccharides are broken down into the monosaccharides glucose, galactose, and fructose, which can be absorbed.

During the cephalic phase of gastric stimulation, which of the following does NOT occur? A. Seeing, smelling, and/or tasting food reflexly increase(s) gastric acid secretion. B. Parasympathetic stimulation of secretory cells in the gastric mucosa occurs. C. Gastrin is secreted into the gastric lumen. D. HCl is secreted into the gastric lumen. E. Pepsinogen is secreted into the gastric lumen.

C. Gastrin is secreted into the gastric lumen.

Which of the following statements regarding protein digestion and absorption is TRUE? A. Cells in the stomach secrete enterokinase, which breaks down proteins into smaller peptides. B. Pepsin and trypsin are proteolytic enzymes that are most active in an acid pH. C. More acid is secreted during the digestion of a high-protein meal than during the digestion of a meal containing little protein. D. The presence of peptides in the stomach inhibits secretion of gastrin. E. Proteins are too large to pass through the pyloric sphincter into the small intestine.

C. More acid is secreted during the digestion of a high-protein meal than during the digestion of a meal containing little protein.

Which of the following statements concerning secretin is correct? A. The most potent stimulus for secretin secretion is the presence of fat in the duodenum. B. Secretin is the most potent stimulus for pancreatic digestive enzyme secretion. C. Secretin is the most potent stimulus for pancreatic HCO3- secretion. D. Secretin stimulates secretion by the parietal and chief cells. E. Secretin stimulates gastrin secretion by parietal cells.

C. Secretin is the most potent stimulus for pancreatic HCO3- secretion.

Which is TRUE about fat-soluble vitamins? A. They must be digested to fatty acids and monoglyceride before being absorbed. B. Examples include vitamins A, B12, and D. C. Their normal absorption depends on normal secretion of bile salts. D. They are absorbed into GI capillaries and travel immediately to the liver in the hepatic portal vein, for storage. E. They don't need to be ingested because the body can manufacture all of them in sufficient quantities.

C. Their normal absorption depends on normal secretion of bile salts.

Which of the following is NOT secreted by the exocrine pancreas? A. bicarbonate ions B. amylase C. bile salts D. trypsinogen E. lipase

C. bile salts

Which is caused by increased levels of the hormone cholecystokinin? A. contraction of the sphincter of Oddi B. inhibition of pancreatic enzyme secretion C. contraction of the gallbladder D. secretion of HCO3- from the pancreatic duct cells E. secretion of gastric H+

C. contraction of the gallbladder

Which of the following plays a main role in stimulating the secretion of the hormone gastrin? A. the hormone secretin B. the hormone cholecystokinin (CCK) C. distention of the stomach D. an increase in [H+] in the lumen of the stomach E. histamine

C. distention of the stomach

Which of the following molecules crosses the luminal membrane of intestinal cells by facilitated diffusion? A. glucose B. lactose C. fructose D. galactose E. maltose

C. fructose

Bile pigments: A. are important for fat digestion. B. are formed from catabolism of the globin part of hemoglobin. C. impart color to the bile, feces, and urine. D. are amphipathic molecules that emulsify fats. E. are completely reabsorbed in the distal ileum.

C. impart color to the bile, feces, and urine.

The enzyme lactase: A. is involved directly in the digestion of proteins. B. is necessary for the breakdown of milk fats. C. is embedded in the luminal plasma membranes of intestinal epithelial cells. D. promotes the formation of and storage of bile by the gallbladder. E. is overproduced and released by secretory cells in the small intestine in the condition known as lactose intolerance.

C. is embedded in the luminal plasma membranes of intestinal epithelial cells.

Constipation: A. is associated with symptoms caused by accumulation of toxins present in feces. B. is caused by failure to defecate at least once a day. C. may be prevented by ingestion of foods with a high proportion of cellulose and other indigestible carbohydrates. D. results in metabolic acidosis. E. occurs in people who are lactose intolerant when they drink milk.

C. may be prevented by ingestion of foods with a high proportion of cellulose and other indigestible carbohydrates.

During the contractions of gastric emptying: A. the stomach is induced to contract by increased sympathetic activity. B. the pyloric sphincter opens to allow stomach contents to pass quickly and completely into the duodenum. C. the pyloric sphincter closes to allow only a small amount of liquefied chyme to pass into the duodenum with each contraction of the stomach. D. the strength of stomach wall contractions is increased when the duodenum secretes cholecystokinin. E. the strongest contractions are in the antrum of the stomach because the intrinsic pacemaker frequency is fastest there.

C. the pyloric sphincter closes to allow only a small amount of liquefied chyme to pass into the duodenum with each contraction of the stomach.

Ulcers are: A. most common in the gastric mucosa. B. always caused by hypersecretion of gastric acid. C. treated by interventions that inhibit acid secretion. D. caused by removal of the gallbladder. E. most common in the large intestine.

C. treated by interventions that inhibit acid secretion.

Which occurs mainly in the small intestine? A. Gastrin is secreted. B. H+ is secreted from epithelial cells into the lumen. C. Pepsinogen is activated. D. Acidic chyme is neutralized. E. Bile salts are manufactured.

D. Acidic chyme is neutralized.

Which of the following statements about pancreatic enzymes is FALSE? A. Trypsinogen is secreted in an inactive form. B. Pancreatic amylase digests carbohydrates. C. Pancreatic lipase digests fats. D. Except for trypsinogen, other proteolytic enzymes are secreted in active form. E. Trypsinogen is activated by enterokinase.

D. Except for trypsinogen, other proteolytic enzymes are secreted in active form.

A bacterium that has been associated with ulcers is: A. Eschericia coli. B. Clostridium difficile. C. Staphylococcus aureus. D. Helicobacter pylori. E. Streptococcus pyogenes.

D. Helicobacter pylori.

The small intestine: A. normally contains millions of bacteria that digest complex polysaccharides and produce vitamin K. B. secretes amylase, lipase, and various proteases from its epithelial cells. C. is the main site of gastrin secretion. D. absorbs a larger volume of fluid than any other region of the GI tract E. undergoes only peristaltic contractions, both during the digestion of meals and between meals.

D. absorbs a larger volume of fluid than any other region of the GI tract

Which combination of substances would cause the greatest stimulation of gastric HCl secretion when applied to parietal cells? A. somatostatin, gastrin, and histamine B. acetylcholine, histamine, and somatostatin C. somatostatin and acetylcholine D. gastrin, histamine, and acetylcholine E. histamine and gastrin

D. gastrin, histamine, and acetylcholine

Which of the following pathways is activated during the cephalic phase of gastrointestinal control? A. sympathetic nerves to enteric nervous system B. secretion of cholecystokinin C. secretion of secretin D. parasympathetic nerves to enteric nervous system E. short reflexes between the small intestine and stomach

D. parasympathetic nerves to enteric nervous system

Which of the following enzymes is most active at an acidic pH? A. amylase B. lipase C. trypsin D. pepsin E. chymotrypsin

D. pepsin

Bicarbonate is: A. secreted into the lumen by gastric epithelial cells and into the interstitial fluid by pancreatic duct cells. B. secreted into the lumen by pancreatic acinar (exocrine) cells, and into the interstitium by pancreatic duct cells. C. secreted into the lumen by pancreatic duct cells, and into the interstitium by pancreatic acinar (exocrine) cells. D. secreted into the interstitial fluid by gastric epithelial cells, and into the lumen by pancreatic duct cells. E. secreted into the lumen by both gastric epithelial cells and pancreatic duct cells.

D. secreted into the interstitial fluid by gastric epithelial cells, and into the lumen by pancreatic duct cells.

The main source of enzymes that cleave disaccharides into monosaccharides is: A. the pancreas. B. the liver. C. gastric secretory cells. D. the luminal membrane of epithelial cells in the small intestine. E. the salivary glands.

D. the luminal membrane of epithelial cells in the small intestine.

In which region(s) of the GI tract do peristaltic contractions occur? A. the small intestine B. the large intestine C. the stomach D. the esophagus E. All of these options are correct.

E. All of these options are correct.

Which of the following statements is TRUE regarding the emulsification of fats? A. Fat emulsification requires pancreatic lipase. B. Emulsification is the splitting of triglycerides into monoglycerides and free fatty acids. C. Fat emulsification occurs mainly in the liver. D. Emulsification is the production of a chylomicron from triglycerides and protein. E. Fat emulsification requires secretion of bile salts and phospholipids by the liver.

E. Fat emulsification requires secretion of bile salts and phospholipids by the liver.

Which of these are secretions of the parietal cells of the gastric mucosa? A. HCl and pepsinogen B. pepsinogen and intrinsic factor C. gastrin and intrinsic factor D. HCl and gastrin E. HCl and intrinsic factor

E. HCl and intrinsic factor

Which accurately describes lipase? A. It is mainly produced in the liver, and secreted into the small intestine. B. It emulsifies lipids. C. It is secreted by the endocrine pancreas. D. It is produced in the exocrine pancreas, and catalyzes the degradation of chylomicrons into proteins and fats. E. It catalyzes the breakdown of triglycerides into monoglycerides and free fatty acids.

E. It catalyzes the breakdown of triglycerides into monoglycerides and free fatty acids.

Which of the following statements about gastrin is TRUE? A. It is mainly secreted by cells in the epithelium of the duodenum. B. It is an enzyme that is secreted into the lumen of the stomach. C. It is a hormone that is secreted in response to sympathetic stimulation. D. It is an enzyme that breaks down proteins. E. It is a hormone that is secreted in response to the presence of peptides in the stomach.

E. It is a hormone that is secreted in response to the presence of peptides in the stomach.

Which of these is a function of intrinsic factor? A. It is secreted by salivary glands, and is necessary for digestion of vitamin B12. B. It is secreted by parietal cells in the gastric mucosa, and its main function is causing insulin release. C. It is secreted in the stomach, and its main function is activating pepsinogen into pepsin. D. It is secreted by the small intestine mucosa, and its main function is initiating the intrinsic electrical activity of the pacemaker cells in the stomach. E. It is secreted in the stomach, and a deficiency of it would cause anemia.

E. It is secreted in the stomach, and a deficiency of it would cause anemia.

Which of the following statements about neural control of digestion is FALSE? A. Parasympathetic stimulation is excitatory to digestion. B. Sympathetic stimulation is generally inhibitory to digestion. C. Local neural networks (nerve plexuses) regulate digestive functions. D. Nerve plexuses receive input from the autonomic nervous system E. Parasympathetic stimulation inhibits GI exocrine gland secretions.

E. Parasympathetic stimulation inhibits GI exocrine gland secretions.

Which of the following is NOT a part of the swallowing reflex? A. Respiration is inhibited. B. The glottis closes. C. The upper esophageal sphincter relaxes. D. The lower esophageal sphincter relaxes. E. The pyloric sphincter relaxes.

E. The pyloric sphincter relaxes.

Which is NOT true about receptors that mediate digestive reflexes? A. They are located in the gastrointestinal tract wall. B. They include chemoreceptors, osmoreceptors, and mechanoreceptors. C. They may relay information to integrative centers in the CNS or to the enteric plexuses. D. They may be endocrine cells. E. They only activate feedforward pathways.

E. They only activate feedforward pathways.

Which is NOT a function performed by saliva? A. moistening and lubricating food for swallowing B. starch digestion C. enabling the sense of taste D. killing bacteria E. emulsifying lipids

E. emulsifying lipids

Iron is stored in the body mainly as a protein-iron storage complex called: A. glycogen. B. hemochromatosis. C. myoglobin. D. transferrin. E. ferritin.

E. ferritin.

Which of these is a secretion of the endocrine portion of the pancreas? A. trypsinogen B. enterokinase C. amylase D. bicarbonate E. insulin

E. insulin

Bile is synthesized and secreted by the: A. gallbladder. B. gastric mucosa. C. pancreas. D. duodenum. E. liver.

E. liver.

segmentation of the small intestine: A. occurs only between meals, and functions to stimulate the secretion of gastrin and the resulting mass movements that empty the large intestine. B. occurs at a rate of 3 contractions per minute throughout the small intestine, although the strength of contractions is much greater in the ileum, which has a much thicker layer of smooth muscle in its walls. C. functions mainly to prevent any forward movement of chyme, so that all digestion and absorption is complete before undigestible materials move into the jejunum. D. are peristaltic movements that sweep undigestible materials out of the small intestine between meals. E. mixes chyme with digestive enzymes, brings food molecules near the wall for absorption, and slowly moves small intestine contents toward the cecum.

E. mixes chyme with digestive enzymes, brings food molecules near the wall for absorption, and slowly moves small intestine contents toward the cecum.

Which correctly describes a major function of the stomach? A. the complete digestion of protein to amino acids B. maintaining an alkaline pH for the digestion of proteins C. absorption of saliva and chyme into the bloodstream D. lubricating food so it can be formed into a bolus E. storing ingested food and partially digesting macromolecules

E. storing ingested food and partially digesting macromolecules