Sarah Patent Ductus Arteriosus

Signs and Symptoms of Patent Ductus Arteriosus

*symptoms vary depending on the size of the PDA.....a small PDA may not cause any symptoms...usually what tips the MD off the patient may have a PDA is a heart murmur (continuous machinery-like heart murmur) or heart failure in a newborn "CALL" Cardiac: *continuous "machinery-like" murmur*: note this is a continuous murmur, so it is heard during diastole and systole at the left upper sternal border. WHY? It's caused by a turbulent high pressure that is existing during systole and diastole from the aorta allowing blood to enter into the pulmonary artery. *endocarditis risk*: WHY? The high pressure created can affect the lining integrity of the heart allowing bacteria to stick in the heart. increased heart rate *widened pulse pressure*: this is the difference between the systolic and diastolic pressure and it indicates the force the heart needs to contract. In patients with PDA, the diastolic pressure will be decreased, which will lead to a wide difference between systolic and diastolic pressure. According to Open Journal of Pediatrics, this is defined as a difference between systolic and diastolic blood pressure of *greater than 15 to 25 mm Hg, in premature infants and greater than 25 mm Hg in term infants* WHY a wide pulse pressure? When blood is leaving through the extra vessel (hence the patent ductus arteriosus) back into the pulmonary artery, this will decrease diastolic pressure. Remember diastolic pressure is the pressure of the blood in the arteries when the heart is filling or in between beats...hence relaxing). Because the diastolic pressure is lower, it will lead to a wide pulse pressure. *Heart failure*: the heart becomes weak from having to pump blood to the lungs against so much resistance (the pulmonary hypertension). The heart muscle can't pump and blood starts to pool even more in the lungs...crackles, dyspnea, major respiratory problems. *Activity intolerance*: fatigues easily, sweating with activity (eating, activity, crying) *Lungs*: hypertension to the lungs...congested...infections, feeding issues, difficulty breathing (blood is being recirculated to the lungs and this increases pressure and alters breathing) *Loss of Weight* (poor feeding and burning calories to breathe because of the high pressure in the lungs and congestion....failure to thrive)

What the ductus arteriosus is and its function?

It's a blood vessel that *connects the aorta to the pulmonary artery* in a fetus. It should be present in all newborns. However, it should close shortly after birth (usually within 3 days). Its purpose is to help carry blood that is entering the right side of the heart to the rest of the body, hence it allows the blood to bypass the non-functional lungs in the fetus. Remember babies in the womb don't use their lungs yet (they are receiving oxygen from the placenta), so there isn't a reason for blood to pass through the lungs until AFTER birth....which is why the ductus arteriosus will close because it's no longer needed. After birth, the lungs will work and this vessel will close so blood from the right side of the heart can go through the lungs to become oxygenated. Patent ductus arteriosus is more common in premature babies. A large PDA causes problems and will need repair. Many small PDAs may close on their own and usually don't lead to outright symptoms because they are not allowing too much blood to flow to the lungs abnormally.

What is patent ductus arteriosus?

It's a congenital heart defect where the ductus arteriosus does NOT close after birth. This will lead to an increase in pulmonary blood flow. "Patent" means failing to close, hence it stays opened. Therefore, in other words, the patent ductus arteriosus stays open.

Treatment for Patent Ductus Arteriosus

Medication (NSAIDs) to close the ductus arteriosus: Prostaglandin inhibitors, "Indomethacin" This is for premature babies or some young infants that are days old....won't work for older infants or children or adults For children: heart catheterization: a device is used to shut the opening or surgery is performed to tie the structure shut

Why is patent ductus arteriosus a problem...what's the big deal about the vessel not closing after birth?

Unfortunately, more blood will enter the lungs and a left-to-right shunting of blood will occur. A large patent ductus arteriosus will cause blood that has already been oxygenated to pour back into the pulmonary artery to go back to the lungs. This overload of blood to the lungs will stress out the lungs and lead to high pressure in the arteries that feed the lungs. This is known as pulmonary hypertension. Furthermore, because of this high pressure in the arteries the arteries will narrow and the heart will have to pump even harder to get the blood to the lungs, which can lead to heart failure. The heart muscle will tire out and fail. The patient will experience heart failure. This in turn will cause fluid congestion in the lungs along with placing the patient at risk for lung infections, endocarditis (high pressure in the heart can affect the integrity of the lining of the heart leading to infection) etc.