Table 48-7 (Drug therapy diabetes)

Metformin

( lactic acidosis)

canagliflozin dapagliflozin

(UTI)

linagliptin saxaglipin

(pancreatitis)

Bromocriptine

activates dopamine (orthostatic hypotension)

canagliflozin dapagliflozin

deceases renal glucose absorption lead to increased excretion.

Metformin

decreases hepatic glucose production. increase glucose uptake in muscles.

acarbose

delay absorption of complex carbohydrates

miglitol

delay absorption of complex carbohydrates

Pioglitazone Rosiglitazone

increase glucose uptake in muscle decrease endogenous glucose production decrease insulin resistance

pramlintide

slows gastric emptying decreases endogenous glucose output

Nateglinide Repaglinide

stimulate a rapid and short lived release of insulin

Glipizide Glyburide

stimulate release of insulin from pancreatic cells

linagliptin saxaglipin

stimulate release of insulin. decrease hepatic glucose. increatins

Exenatide liraglutide

stimulate release of insulin. slow gastric emptying.