Table19_4_Activity_of_Selected_Cytokines

Erythropoietin

Growth Factor: Increases growth and differentiation of erythrocytes

Thrombopoietin

Growth Factor: Increases growth and differentiation of platelets

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)

Growth Factor: Increases growth and maturation of myeloid stem cells.

Granulocyte Colony-Stimulating Factor (G-CSF)

Growth Factor: Increases numbers and maturity of neutrophils

Interleukin-2 (IL-2)

Pro-Inflammaotry Cytokine: Increases growth and differentiation of T-lymphocytes Enhances natural killer cell activity against cancer cells

Interleukin-6 (IL-6)

Pro-Inflammaotry Cytokine: Stimulates liver to produce fibrinogen and protein C Increases rate of bone marrow production of stem cells Increases numbers of sensitized B-lymphocytes

Interleukin-1 (IL-1)

Pro-Inflammatory Cytokine: Induce fever Stimulates production of prostiglandins Increase growth of CD4+ T-cells

Tumor necrosis factor (TNF)

Pro-Inflammatory Cytokines: Induce fever Major cytokine involved in rheumatoid arthritis damage Increases leukocyte adhesion Participates in graft rejection Induces cachexia and muscle breakdown Induces cell death Stimulates delayed hypersensitivity reaction and allergy