Table19_4_Activity_of_Selected_Cytokines
Erythropoietin
Growth Factor: Increases growth and differentiation of erythrocytes
Thrombopoietin
Growth Factor: Increases growth and differentiation of platelets
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
Growth Factor: Increases growth and maturation of myeloid stem cells.
Granulocyte Colony-Stimulating Factor (G-CSF)
Growth Factor: Increases numbers and maturity of neutrophils
Interleukin-2 (IL-2)
Pro-Inflammaotry Cytokine: Increases growth and differentiation of T-lymphocytes Enhances natural killer cell activity against cancer cells
Interleukin-6 (IL-6)
Pro-Inflammaotry Cytokine: Stimulates liver to produce fibrinogen and protein C Increases rate of bone marrow production of stem cells Increases numbers of sensitized B-lymphocytes
Interleukin-1 (IL-1)
Pro-Inflammatory Cytokine: Induce fever Stimulates production of prostiglandins Increase growth of CD4+ T-cells
Tumor necrosis factor (TNF)
Pro-Inflammatory Cytokines: Induce fever Major cytokine involved in rheumatoid arthritis damage Increases leukocyte adhesion Participates in graft rejection Induces cachexia and muscle breakdown Induces cell death Stimulates delayed hypersensitivity reaction and allergy