Vitamin B-12

What are contraindications to Vitamin b12?

Cobalt sensitivity Leiber's Disease(atrophy of optic nerve)

what should be monitored for the first 48 hours after giving vitamin b12?

serum potassium; give oral potassium if it is too low.

How should vitamin b12 be taken with regard to food?

vitamin b-12 should be taken with food to increase absorption.

what routes can vitamin b-12 be given?

vitamin b12 can be given sub q or IM.

What are the adverse drug reactions to Vitamin b12?

-hypokalemia -anaphylaxis

What are causes of vitamin b-12 deficiency?

1)Strict vegetarians 2)lack of intrinsic factor 3)bariatric surgery

Vitamin b-12 is needed in two metabolism pathways, what are they?

1)methylmalonyl-CoA(responsible for breaking down fatty acids; the lack of this results in neurological symptoms seen in pernicious anemia). 2)metabolism of folate

what are the two anemias vitamin b-12 is used to treat?

1)pernicious anemia(life long replacement) 2)megaloblastic anemia