Vitamin B-12
What are contraindications to Vitamin b12?
Cobalt sensitivity Leiber's Disease(atrophy of optic nerve)
what should be monitored for the first 48 hours after giving vitamin b12?
serum potassium; give oral potassium if it is too low.
How should vitamin b12 be taken with regard to food?
vitamin b-12 should be taken with food to increase absorption.
what routes can vitamin b-12 be given?
vitamin b12 can be given sub q or IM.
What are the adverse drug reactions to Vitamin b12?
-hypokalemia -anaphylaxis
What are causes of vitamin b-12 deficiency?
1)Strict vegetarians 2)lack of intrinsic factor 3)bariatric surgery
Vitamin b-12 is needed in two metabolism pathways, what are they?
1)methylmalonyl-CoA(responsible for breaking down fatty acids; the lack of this results in neurological symptoms seen in pernicious anemia). 2)metabolism of folate
what are the two anemias vitamin b-12 is used to treat?
1)pernicious anemia(life long replacement) 2)megaloblastic anemia