Animal Care and Use Program -ACUP
AALAC certification is obtained by this group
OAWA
Just in time protocol review is done by this group
OAWA
Post approval monitoring
OAWA
Cores billing is done by this group
DAC
Veterinary care provided by this agency
DAC
ACUP
Every program must have: Institutional Official (IO) Attending Veterinarian (AV) Institutional Animal Care and Use Committee (IACUC)
Laws, regulations and guidelines
Primary Laws • Animal Welfare Act (AWA) • Health Research Extension Act (HREA) Regulatory Authority • USDA • OLAW
Category I vs. Category II Institution
e Association for the Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) Category I: Accredited by AAALAC • Monitored by annual reports and triennial program review and site visits • Considered "gold standard" Category II: Not accredited by AAALAC • Self-monitored • Additional reporting requirements to OLAW
OLAW and the Health Research Extension Act
• According to PHS Policy and the Guide: - Definition of animal: Any vertebrate animal (warm- or cold-blooded) • HREA (PHS Policy and the Guide) applies to all federally funded animal research (i.e., NIH and National Research Institutes). • Office of Laboratory Animal Welfare (OLAW) is responsible for administration of the PHS Policy • Monitored by annual reports to OLAW • Additional monitoring requirements depend on whether the Institution is a Category I or a Category II Institution
USDA and the Animal Welfare Act
• Animal Welfare Act (AWA) of 1966 • Definition of animal: Warm-blooded vertebrates, except mice (Mus), Rats (Rattus), and Birds • Applies to all research on USDA species • Regulated by US Dept. of Agriculture (USDA), Animal and Plant Health Inspection Service (APHIS), Animal Care • Monitored by annual reports and unannounced annual inspections by a USDA Veterinary Medical Officer
Vanderbilt Animal Care and Use Program
• Category I Institution - Accredited by AAALAC since 1967 • At Vanderbilt, all animal research, regardless of species or funding source, must comply with AWA rules/regulations and HREA guidelines ( PHS Policy and the "Guide") and any applicable federal, state, local laws and institutional policies • Reports annually to AAALAC, OLAW, and USDA • Has annual unannounced inspections from the USDA • Has triennial scheduled site visits by AAALAC (next site visit: March 7-9, 2017)
OLAW and the Health Research Extension Act
• Health Research Extension Act (HREA) of 1985 - Provides statutory mandate for the Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy) • PHS Policy requires institutions to follow the Guide for the Care and Use of Laboratory Animals (the "Guide")
The 3 Rs -Ethical considerations in Animal research
• The Three R's of Humane Animal Research - Replacement - Can the animal model be replaced by another model (simulation), or a less sentient animal (invertebrates such as worms)? - Reduction - Is the number of animals involved the minimum number possible without loss of useful information? - Refinement - Is the experiment designed to reduce any pain, stress or distress that the animals may experience?
