Assessments 1 and 2

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How many constant-region domains in a single heavy chain of IgA?

3

How many constant-region domains in a single heavy chain of IgE?

4

Which genes code for Class II MHC proteins in the mouse?

A and E

Which pathway of complement activation is shown in the diagram?

Alternative

Which of the following proteins do not have Immunoglobulin domains?

Antibodies T cell receptors Major Histocompatibility Complex (MHC) CD4 proteins All of these structures contain immunoglobulin domains

Which part of the IgG molecule is encircled by the blue dotted line?

Antigen-binding site

What is the name of this leukocyte (white blood cell)? Note the dark stained cytoplasmic granules

Basophil

Which of the cells below is found in the lowest percentage in human blood?

Basophil

MHC Class I has the following attributes:

Binds smaller peptides than MHC Class II

Identify the lymphoid organ at the tip of the arrow.

Bursa of Fabricius

The first component of the complement system to be activated in the Classical Pathway is?

C1qrs

Activated C1s activates which components of complement?(There are two correct answers. You must choose both to get full credit.)

C2 and C4

Name a complement component that is classified as an anaphylatoxin.Choose from one of the following: C3a, C4a, C5a, C4b, C3bBb)

C3a, C4a, C5a

Which complex is the C5 covertase?

C3bBbC3b

Hydrolysis of C5 yields the _____ fragment which diffuses away from the site and functions as an anaphylatoxin.

C5a

Hydrolysis of C5 by C4b2b3b (Classical Pathway Convertase) yields the _____ fragment which binds near the antigenic site and leads to activation of the Terminal Pathway.

C5b

This component of complement has 10 to 17 molecules polymerized into the Membrane Attack Complex (MAC).

C9

This complex of five different polypeptide chains that associate to form three dimers is closely associated with T-cell receptors.

CD3

This molecule most closely represents the structure of

CD4

All nucleated cells express MHC Class I for surveillance of infection by

CD8+ T cells

Which part of the IgG molecule is encircled by the dotted line?

CH

Which part of the IgG molecule is encircled by the blue dotted line?

CL

The diagrams below are most likely

Class I binding "motifs"

The diagram below is most likely

Class II binding "motif"

What is the first step in the Terminal pathway of complement activation?

Cleavage of C5 to C5a and C5b

This outer layer of a lymph node is rich in B-cells.

Cortex

Endogenous Ag is processed in the _________ pathway and presented on the membrane with Class I MHC.

Cytosolic

When genetic rearrangements of the immunoglobulin genes occurs, which is the correct sequence of major events that occur when heavy chain genes are rearranged?

D-J joining, V-DJ joining

In the diagragm, the "?" is directed towards ________ chain genes of the TCR.

Delta

Which type of cell is shown in the micrograph below?

Dendritic Cell

IgM is not:

Dimeric

Lymphocytes may leave the lymph node through this structure.

Efferent lymphatic

What is the name of this leukocyte (white blood cell)? Note the dark stained cytoplasmic granules (2)

Eosinophil

Antibodies recognize specific structures known as:

Epitopes

What is the Greek symbol for the heavy chain of IgE?

Epsilon

The alpha-beta T cell receptor resembles what part of the antibody?

Fab

Choose proteins that are reactive in the Alternative Pathway of complement activation.(There are two correct answers.)

Factor B and Properdin

Which part of the IgG molecule is encircled by the dotted line?

H-Chain

This portion of the immunoglobulin (Ig) molecule allows for flexibility

Hinge region

Which CLASS of immunoglobulin is shown in this diagram of the molecular structure?

IdA

The T cell receptor is as diverse as the B cell receptor because of:

Large number of Variable regions

Which molecule is most likely shown in the diagram?

MHC Class I

The CLIP peptide is directly associated with

MHC Class II

Which is the antigen recognition "unit" on a B-cell?

Membrane immunoglobulin (mIg)

What is the name of this leukocyte (white blood cell)?

Neutrophil

Which of the cells below is found in the highest percentage in human blood?

Neutrophil

If cleavage of a hairpin intermediate during DNA rearrangements yields a single-stranded end, then during the subsequent repair process, a complementary _________ may be added to create a palindromic sequence.

P-nucleotide

This layer of a lymph node is rich in T-cells.

Paracortex

Which best describes this step (arrow and question mark) of exogenous antigen uptake by the phagocyte depicted in green?

Phagocytosis

What circumstances activate the Alternative Pathway?

Recognition of foreign components in the absence of bound antibody

Identify the lymphoid organ at the tip of the "B" arrow.

Spleen

Which of the following is part of the Endogenous pathway?

TAP 1 proteins

Which pathway of complement activation is shown in the diagram?

Terminal

What is illustrated by the diagram below?

The genes for the Kappa light chain are not arranged the same in the embryo as they are in the adult.

Identify the lymphoid organ at the tips of the arrows.

Tonsils

How many protein chains compose a single IgG molecule?

Two heavy chains and two light chains.

Which part of the IgG molecule is encircled by the blue dotted line?

VH

Which part of the IgG molecule is encircled by the blue dotted line?

VL

Among the human immunoglobulin heavy chain loci, which gene segments have the greatest number of loci?

Variable (V)

Among the human immunoglobulin light chain loci, which gene segments have the greatest number of loci?

Variable (V)

What name describes the cell layer at the tip of the pipet in tube 23?(there are two correct answers and both must be selected for full credit)

White cell, buffy coat

Which of the following is a function of Terminal Deoxynucleotidal Transferase?

addition of random nucleotides

An antigen is

can be protein, sugar or lipid.

What is the name of this leukocyte (white blood cell)?

lymphocyte

Which enzyme will fragment an IgG molecule as shown below?

pepsin


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