Assessments 1 and 2
How many constant-region domains in a single heavy chain of IgA?
3
How many constant-region domains in a single heavy chain of IgE?
4
Which genes code for Class II MHC proteins in the mouse?
A and E
Which pathway of complement activation is shown in the diagram?
Alternative
Which of the following proteins do not have Immunoglobulin domains?
Antibodies T cell receptors Major Histocompatibility Complex (MHC) CD4 proteins All of these structures contain immunoglobulin domains
Which part of the IgG molecule is encircled by the blue dotted line?
Antigen-binding site
What is the name of this leukocyte (white blood cell)? Note the dark stained cytoplasmic granules
Basophil
Which of the cells below is found in the lowest percentage in human blood?
Basophil
MHC Class I has the following attributes:
Binds smaller peptides than MHC Class II
Identify the lymphoid organ at the tip of the arrow.
Bursa of Fabricius
The first component of the complement system to be activated in the Classical Pathway is?
C1qrs
Activated C1s activates which components of complement?(There are two correct answers. You must choose both to get full credit.)
C2 and C4
Name a complement component that is classified as an anaphylatoxin.Choose from one of the following: C3a, C4a, C5a, C4b, C3bBb)
C3a, C4a, C5a
Which complex is the C5 covertase?
C3bBbC3b
Hydrolysis of C5 yields the _____ fragment which diffuses away from the site and functions as an anaphylatoxin.
C5a
Hydrolysis of C5 by C4b2b3b (Classical Pathway Convertase) yields the _____ fragment which binds near the antigenic site and leads to activation of the Terminal Pathway.
C5b
This component of complement has 10 to 17 molecules polymerized into the Membrane Attack Complex (MAC).
C9
This complex of five different polypeptide chains that associate to form three dimers is closely associated with T-cell receptors.
CD3
This molecule most closely represents the structure of
CD4
All nucleated cells express MHC Class I for surveillance of infection by
CD8+ T cells
Which part of the IgG molecule is encircled by the dotted line?
CH
Which part of the IgG molecule is encircled by the blue dotted line?
CL
The diagrams below are most likely
Class I binding "motifs"
The diagram below is most likely
Class II binding "motif"
What is the first step in the Terminal pathway of complement activation?
Cleavage of C5 to C5a and C5b
This outer layer of a lymph node is rich in B-cells.
Cortex
Endogenous Ag is processed in the _________ pathway and presented on the membrane with Class I MHC.
Cytosolic
When genetic rearrangements of the immunoglobulin genes occurs, which is the correct sequence of major events that occur when heavy chain genes are rearranged?
D-J joining, V-DJ joining
In the diagragm, the "?" is directed towards ________ chain genes of the TCR.
Delta
Which type of cell is shown in the micrograph below?
Dendritic Cell
IgM is not:
Dimeric
Lymphocytes may leave the lymph node through this structure.
Efferent lymphatic
What is the name of this leukocyte (white blood cell)? Note the dark stained cytoplasmic granules (2)
Eosinophil
Antibodies recognize specific structures known as:
Epitopes
What is the Greek symbol for the heavy chain of IgE?
Epsilon
The alpha-beta T cell receptor resembles what part of the antibody?
Fab
Choose proteins that are reactive in the Alternative Pathway of complement activation.(There are two correct answers.)
Factor B and Properdin
Which part of the IgG molecule is encircled by the dotted line?
H-Chain
This portion of the immunoglobulin (Ig) molecule allows for flexibility
Hinge region
Which CLASS of immunoglobulin is shown in this diagram of the molecular structure?
IdA
The T cell receptor is as diverse as the B cell receptor because of:
Large number of Variable regions
Which molecule is most likely shown in the diagram?
MHC Class I
The CLIP peptide is directly associated with
MHC Class II
Which is the antigen recognition "unit" on a B-cell?
Membrane immunoglobulin (mIg)
What is the name of this leukocyte (white blood cell)?
Neutrophil
Which of the cells below is found in the highest percentage in human blood?
Neutrophil
If cleavage of a hairpin intermediate during DNA rearrangements yields a single-stranded end, then during the subsequent repair process, a complementary _________ may be added to create a palindromic sequence.
P-nucleotide
This layer of a lymph node is rich in T-cells.
Paracortex
Which best describes this step (arrow and question mark) of exogenous antigen uptake by the phagocyte depicted in green?
Phagocytosis
What circumstances activate the Alternative Pathway?
Recognition of foreign components in the absence of bound antibody
Identify the lymphoid organ at the tip of the "B" arrow.
Spleen
Which of the following is part of the Endogenous pathway?
TAP 1 proteins
Which pathway of complement activation is shown in the diagram?
Terminal
What is illustrated by the diagram below?
The genes for the Kappa light chain are not arranged the same in the embryo as they are in the adult.
Identify the lymphoid organ at the tips of the arrows.
Tonsils
How many protein chains compose a single IgG molecule?
Two heavy chains and two light chains.
Which part of the IgG molecule is encircled by the blue dotted line?
VH
Which part of the IgG molecule is encircled by the blue dotted line?
VL
Among the human immunoglobulin heavy chain loci, which gene segments have the greatest number of loci?
Variable (V)
Among the human immunoglobulin light chain loci, which gene segments have the greatest number of loci?
Variable (V)
What name describes the cell layer at the tip of the pipet in tube 23?(there are two correct answers and both must be selected for full credit)
White cell, buffy coat
Which of the following is a function of Terminal Deoxynucleotidal Transferase?
addition of random nucleotides
An antigen is
can be protein, sugar or lipid.
What is the name of this leukocyte (white blood cell)?
lymphocyte
Which enzyme will fragment an IgG molecule as shown below?
pepsin
