Bio 97 All Canvas Quizzes
Which of the following terms refer to the case when a mutation results in a partial loss of the functional activity of a gene product?
Leaky mutation, Hypomorphic mutation
Which of the following terms refer to the case when a mutation results in a complete loss of the functional activity of a gene product?
Null mutation
The 'wild-type' phenotype is the most common phenotype observed in a population T/F
True
We have learned that genotype specifies phenotype. However, there are some traits and diseases, such as polydactyly, where not all individuals who have the disease-causing genotype express the disease phenotype, and instead display a wild-type phenotype. This phenomenon is referred to as
incomplete penetrance
Which of the following terms refer to the case when a mutation results in a significant decrease or a complete loss of the functional activity of a gene product?
loss-of-function mutation
Recent studies suggest that having the A blood type increases the risk of serious complications for patients suffering from COVID-19. Sarah doesn't know her blood type, but she knows her father is type O and her mother is type AB. What is the probability, from 0 to 100 percent, that Sarah is blood type A? Enter a single whole number from 0 to 100.
50
A man affected with the autosomal recessive disorder cystic fibrosis (CF) mates with a normal woman. Which of the following statements about the transmission of CF to his kids is TRUE? (Choose all that are correct)
All of his sons will be carriers All of his daughters will be carriers Here the cross is dd (affected) x DD (normal). All the kids are Dd.
Gain-of-function mutations identify alleles that have a acquired a new function, or have their expression altered in such a way that gives them substantially [ Select "the same", "more", "less"] activity than the wild-type allele. Gain-of-function mutations [ Select "are equally likely to be dominant or recessive", "are usually dominant", "are usually recessive"] .
Answer 1: more Answer 2: are usually dominant
A 'wild-type' allele is the allele that is [ Select "missing from", "least common in", "most common in"] a population, and that encodes a [ Select "partially", "fully", "non"] functional gene-product.
Answer 1: most common in Answer 2: fully
Humans can have one of 4 possible blood types: A, B, AB, or O. Blood type is a phenotype. The blood type phenotype is controlled by 3 alleles (A, B, and O)* that are common in the population. Obviously, any individual can only have 2 of those 3 alleles. Fill in the missing values in the table.
Answer 1:AB Answer 2:B
A unaffected couple has a child affected with Klansky's disease. Which mode(s) of inheritance can be RULED OUT for Klansky's disease (choose all that are correct):
Autosomal Dominant X-linked Dominant This is a straight-forward application of Rule 1 from lecture. Rule 1 states that "If unaffected parents have an affected kid, dominance can be ruled out"
An unaffected couple has a daughter affected with Koopskiʼs disease. Which type(s) of inheritence can be ruled out for Koopskiʼs disease? (Choose all that are correct)
Autosomal Dominant X-linked Dominant X-linked Recessive This is an example of the "Rule 1 & 4 Combo" from lecture.
A husband and wife are both affected with Kloxie's disease, but both their children are unaffected. Which mode(s) of inheritance can be RULED OUT for Kloxie's disease (choose all that are correct):
Autosomal Recessive X-linked Recessive Here we apply Rule 2 from lecture, which states "If two affected parents have an unaffected kid, recessiveness can be ruled out"
In chi-squared analysis, by convention, when the p-value for the difference between the observed experimental outcomes and the expected outcome is less than 5 percent (p < 0.05)....
The experimental results are considered to be statistically significantly different from the expected outcome. The difference between the experimental results (data) and the expected results are so large (statistically) that we should rule out the hypothesis that generated those expectations
