Biochemistry Ch 17

The balanced equation of the degradation of CH₃(CH₂)₁₀COOH via the B-oxidation pathway is:

CH₃(CH₂)₁₀COOH + 5 FAD + 5 NAD + 6 CoA-SH + 5 H₂O + ATP → 6 Acetyl-CoA + 5 FADH₂ + 5 NADH + 5 H + AMP + PPi

The major site of formation of acetoacetate from fatty acids is the;

liver

In the disease sprue, vitamin B₁₂ (cobalamin) is poorly absorbed in the intestine, resulting in B₁₂ deficiency. If each of the following fatty acids were in the diet, for which one would the process of fatty acid oxidation be most affected in a patient with sprue?

CH₃(CH₂)₁₂COOH

Which compound is an intermediate to the B-oxidation of fatty acids?

CH₃COCH₂COSCoA

Free fatty acids in the blood stream are?

Carried by the protein serum albumin

Fatty acids are activated to actyl-CoA(s) and the acyl group is further transferred to carnitine because?

acyl-carnitines readily across the mitochondrial but acyl-CoA(s) do not

Carnitine is?

essential for intracellular transport of fatty acids.

Which of the following is (are) true of the oxidation of 1 mol palmitate (a 16 carbon saturated fatty acid 16:0) by the B-oxidation pathway, beginning with the free fatty acid in the cytoplasm?

1,2,5

If the 16-carbon saturated fatty acids palmitate is oxidized completely to carbon dioxide and water via the B-oxidation pathway and the citric acid cycle and all of the energy-conserving products are used to drive ATP synthesis in the mitochondrion, the net yield of ATP per molecule of palmitate is?

108

Which of the following is (are) true of the B-oxidation of long chain fatty acids?

2,3,5

Which of the following statements apply to the B-oxidation of fatty acids?

3 and 5 only

Saturated fatty acids are degraded by the stepwise reactions of B-oxidation, producing acetyl-CoA under aerobic conditions, how many ATP molecules would be produced as a consequence of removal of each acetyl-CoA?

4

What is the correct order of function of the following enzyme of B oxidation? 1) B-oxidation-CoA dehydrogenase 2) Thiolase 3) Enoyl-CoA hydrase 4) Acyl CoA dehydrogenase

4,3,1,2

The conversion of palmiatoyl-CoA (16:0) to nyristoyl-CoA (14:0) and 1 mol of acetyl CoA by the B-oxidation pathway?

8 mol of FADH₂ are formed.

Transport of fatty acids from the cytoplasm to the mitochondrial matrix requires?

ATP, Carnitine, and coenzyme A

When comparing the B-oxidation and W-oxidation pathways, which one of the following statements is correct?

B oxidatioin occurs at the carboxyl end of the fatty acid whereas W oxidation occurs at the methyl end.

Which of these is able to cross the inner mitochondrial membrane?

Fatty Acyl-carnitine

Lipoprotein lipase acts in?

Hydrolysis of triacyclgerols of plasma lipoproteins to supply fatty acids to various tissues.

The role of hormone sensitive triacylgycerol lipase is to?

Hydrolyze triacylgycerol stored in adipose tissue.

During B oxidation of fatty acids,___________ is produced in peroxisomes but not in mitochondria

H₂0₂

Which of the following statements concerning the B-oxidation of fatty acids is true?

The free fatty acids must be converted to a thioester before the process of B-oxidation commences.

Ketone bodies are formed in the liver and transported to the extrahepatic tissues mainly as:

beta-hydroxybutyric acid

If an aerobic organism were fed each of the following four compounds as a source of energy, the energy yield per from these molecules would be in the order?

palmitate>glucose>akanine

The following fatty acids, in which the indicated carbons is labeled with 14 C, is fed to an animal ¹⁴CH₃(CH₂)₉COOH. After allowing 30 minutes for fatty acid B oxidation, the label would most likely be recovered in:

propinoyl-CoA

The carbon atoms from a fatty acid with an odd number of carbons will enter the citric acid cycle as acetyl-CoA and:

succinyl-CoA