Blood Bank 1 ABO System Study Questions
Record all possible genotypes for each given phenotype in the chart below
A AO, AA B BO, BB O OO AB AB
Describe the reciprocal relationship between ABO antigens and antibodies
Antigen present - antibody absent Antigen absent - antibody present
Name the terminal sugars responsible for the A, B, and H antigens
H: fucose sugar A: N-acetylgalactoseamine sugar B: galactose sugar
Place the following phenotypes in order of H expression when tested with anti-H lectin: A1, A2, A1B, A2B, B, O, Oh
Most H O>A2>B>A2B>A1>A1B>Oh Least H
Why is reverse typing not performed on newborns
They don't have antibodies yet, if any are detected, it is based on mom's blood type Won't show ABO discrepancies
What are all of the possible ABO phenotypes of the offspring from the mating of a group A to a group B individual? a) A, B, AB, O b) A, B, AB c) A, B d) A, B, O
a) A, B, AB, O
Describe anti-A,B with regards to: a) which blood group(s) produce it b) immunoglobulin class c) ability to cause HDFN, why or why not?
a) group O b) 50/50 IgG&IdM c) yes, IgG is present and can cross placenta
Describe the Bombay phenotype with regards to: a) gene present at the H locus b) ABH antigens found on the cells c) naturally occurring antibodies found in the serum d) transfusion requirements
a) hh b) none c) anti-A, anti-B, anti-A,B, and allo-anti-H d) Other Bombay donor negative for H antigen
Describe ABO antibodies with respect to: a) development b) predominant immunoglobulin class c) optimal phase of reactivity d) clinical significance
a) none at birth, detectable amounts at 3-6 months, highest at 5-10 years, stable, then gradual decrease when elderly b) IgM c) room temp or colder, IS rxns d) #1 in clinical significance, can cause HTRs and HDN
A patient specimen for ABO typing gave the following results: Anti-A: 4+, Anti-B: 4+, Anti-A,B: 4+ A1: 0, B: 0, O (I, II): 0 The patient's ABO group is: a) A b) B c) AB d) O
c) AB
The major immunoglobulin class of anti-A in a group B individual is : a) IgA b) IgE c) IgG d) IgM
d) IgM
What ABH substances would be found in the saliva of a group A non-secretor? a) A only b) A & H c) B & H d) None
d) none