Ch 2 Blood bank

Hemolysis was observed at room temp when testing a patients serum with reagent red cells used for screening. When this test was repeated using the patients plasma, no hemolysis was observed. What was the most likely explanation for the different reactions.

Complement activation was inhibited by calcium in the plasma sample

What is the potential effect in a tube agglutination test if a red cell suspension with a concentration greater than 5% is used

False negatives

A technologist added 4 drops of a 5% red cell suspension instead of the required 1 drop to a hemagglutination test. What is the potential consequence to the test results

False- Negative

what part of the immunoglobulin molecule distinguishes the isotype

Heavy chain

Which immunoglobulins class is impacted by the zeta potential in a hemagglutination test

IgG

Which of the following requires adjustment in order to enhance the reaction of an antibody in vitro

Increase the incubation time in the incubator

After addition of anti-A reagent to a patient's red cell suspension, agglutination was observed. The result with anti-B reagent was negative. what is the interpretation of this patient's ABO typing

Patient is group A

Extravascular destruction of blood cells occurs in the

Spleen

how does complement activation demonstrate within the body

cell lysis enhanced cell clearance neutrophil activation generation of vasoactive amines

To determine the presence of a red cell antibody in a patient's sample, what is the source of antigen

commercial reagent red cells

select the term that describes the unique part of the antigen that is recognized by a corresponding antibody

epitope

what is the chemical composition of an antibody

glycoprotien

which of the following situations can enhance hemagglutination reaction

increasing the incubation time

what classification of molecules does not make a good immunogenic substance

lipid

where is the antigen located in a hemagglutination test

on the red cell membrane

what term describes molecules that bind to an antigen to increase phagocytosis

opsonins

What cells can produce antibodies

plasma cells

what biological molecules are considered the most immunogenic

protiens

what term describes the number of antigen-binding sites per molecule of antibody

valency

After performing a tube test, the supernatant of the test was pinkish and the red cell button was small. How do you interpret the33 result of this test

1+

After adding antigen and antibody to a test tube, one large agglutinate was observed. How should this reaction be graded?

4+

Which of the following components in the complement cascade mediates the lysis of the target cells

C5 to C9