Ch 2 Blood bank
Hemolysis was observed at room temp when testing a patients serum with reagent red cells used for screening. When this test was repeated using the patients plasma, no hemolysis was observed. What was the most likely explanation for the different reactions.
Complement activation was inhibited by calcium in the plasma sample
What is the potential effect in a tube agglutination test if a red cell suspension with a concentration greater than 5% is used
False negatives
A technologist added 4 drops of a 5% red cell suspension instead of the required 1 drop to a hemagglutination test. What is the potential consequence to the test results
False- Negative
what part of the immunoglobulin molecule distinguishes the isotype
Heavy chain
Which immunoglobulins class is impacted by the zeta potential in a hemagglutination test
IgG
Which of the following requires adjustment in order to enhance the reaction of an antibody in vitro
Increase the incubation time in the incubator
After addition of anti-A reagent to a patient's red cell suspension, agglutination was observed. The result with anti-B reagent was negative. what is the interpretation of this patient's ABO typing
Patient is group A
Extravascular destruction of blood cells occurs in the
Spleen
how does complement activation demonstrate within the body
cell lysis enhanced cell clearance neutrophil activation generation of vasoactive amines
To determine the presence of a red cell antibody in a patient's sample, what is the source of antigen
commercial reagent red cells
select the term that describes the unique part of the antigen that is recognized by a corresponding antibody
epitope
what is the chemical composition of an antibody
glycoprotien
which of the following situations can enhance hemagglutination reaction
increasing the incubation time
what classification of molecules does not make a good immunogenic substance
lipid
where is the antigen located in a hemagglutination test
on the red cell membrane
what term describes molecules that bind to an antigen to increase phagocytosis
opsonins
What cells can produce antibodies
plasma cells
what biological molecules are considered the most immunogenic
protiens
what term describes the number of antigen-binding sites per molecule of antibody
valency
After performing a tube test, the supernatant of the test was pinkish and the red cell button was small. How do you interpret the33 result of this test
1+
After adding antigen and antibody to a test tube, one large agglutinate was observed. How should this reaction be graded?
4+
Which of the following components in the complement cascade mediates the lysis of the target cells
C5 to C9