Chemistry Lecture Quiz 2

Portal cirrhosis is a chronic disease of the liver. Observed on an electrophoretic serum pattern, a predominant characteristic of this disease is:

A bridging effect between the beta and gamma bands

Unconjugated bilirubin circulated in the bloodstream is bound to:

Albumin

The acute phase reactant protein that also inhibits proteolysis and has the highest concentration within its globulin fraction is:

Alpha 1 - antitrypsin

A protein that is normally produced by the fetus but is found in increased amounts in the amniotic fluid in cases of spina bifida is:

Alpha 1 - fetoprotein

Azotemia refers to:

An increase in urea in blood

Which of the following best describes the correct collection and handling conditions for a blood ammonia measurement?

Draw lithium or sodium heparin tube, place in ice bath immediately, separate cells and plasma in refrigerated centrifuge, immediately remove plasma and freeze if analytical testing is delayed

Of the following protein fractions, the one that is NOT produced in the liver is:

Gamma globulin

A glycoprotein that binds with hemoglobin to facilitate the removal of hemoglobin by the reticuloendothelial system is:

Haptoglobin

Serum bilirubin is unstable because of:

Light sensitivity

The term below that is related to the ability of plasma proteins to maintain plasma water volume is:

Oncotic pressure

When elevated amounts of bilirubin are presented to the liver with elevated serum unconjugated bilirubin, what type of jaundice occurs?

Prehepatic

Production of bilirubin occurs in the _____ , and conjugation of bilirubin to glucuronide occurs in the _____.

RES; liver

Monitoring of ________ in patients on chemotherapy due to leukemia, lymphoma, or multiple myeloma is necessary to avoid nephrotoxicity.

Serum uric acid

Which of the following proteins is indicative of a patient's nutritional status?

Transthyretin

The enzyme that conjugates bilirubin in the hepatocyte is:

UDP - glucuronyl transferase

Bilirubin is reduced to _____ in the small intestine.

Urobilinogen

Many compounds in human serum contain nitrogen. Some of these substances are protein in nature, whereas others are nonprotein nitrogen compounds. What is the compound that is comprised of 16% nitrogen?

BUN

Uric acid is derived from the:

Catabolism of purines