CITI Training Modules

Which of the following is not typically a function of the IACUC?

Review and score scientific value for animal protocols submitted.

Which of the following is most directly related to successful mentoring?

Someone who is committed to the professional development of the trainee.

Which of the following statements concerning euthanasia of mice is true?

The selection of an appropriate euthanasia method should address considerations of humaneness to the animal, safety for the staff and onlookers, and experimental needs.

What is the most appropriate process for research collaborators to use in determining which journal they should submit their work to?

The research team should discuss the issue early on and while the project is ongoing.

What is the primary responsibility of oversight bodies (such as an IRB or IACUC)?

To determine compliance with regulatory requirements, including those relating to protecting research subjects.

The most important factor in determining whether a research collaboration will be successful is:

Whether there is ongoing communication among the team members about their goals and responsibilities.

The entity that normally is supposed to determine whether an academic researcher's conflict of interest can be managed is:

A conflict of interest committee

Which of the following most directly contributed to the establishment of the National Research Act and the creation of the Belmont Report?

A description of the research's potential benefits and risks

Which location is not appropriate for hand washing after working with human material in the laboratory?

A hand washing sink in the break room

Which of the following is most likely to create a poor relationship between a mentor and a trainee?

A mentor who recruits trainees merely for the mentor's own career advancement.

Which of the following is a true statement regarding assessment of pain or distress in mice?

A mouse with a moderately painful condition may appear and behave normally.

When mice are received from another institution or vendor:

A quarantine period is often necessary to make sure that the new mice do not carry diseases into the colony.

Which of the following statements is true regarding the responsibilities of a reviewer?

A reviewer's conflict of interest should be disclosed to the journal editor or grant agency.

Which of following protocols is the one that is most likely to require IRB review?

A study to evaluate a newly designed wheelchair by asking elderly individuals to use it.

What does each employer that has workers with occupational exposure to human blood or OPIM need to have?

A written Exposure Control Plan that identifies who is exposed and outlines protective measures.

Which of the following statements best describes decontamination in the laboratory environment?

All work surfaces must be decontaminated with an appropriate disinfectant after the completion of a procedure, when surfaces are overtly contaminated, and immediately after any spill.

Which statement is true regarding the conduct of surgery in mice?

Applicable federal mandates require the use of aseptic technique for survival surgery in mice.

Which statement is true regarding venipuncture procedures in mice:

Because of potential damage to the heart, blood collection by cardiac puncture is usually permitted only as a terminal procedure.

Which of the following statements is true regarding authorship practices?

Both within and between disciplines, practices differ with regard to who should be included as an author, and in what order they should be listed.

Which of the following is true regarding the reporting of research results?

Clear specification of the methods and procedures used is essential.

According to the AVMA Guidelines for the Euthanasia of Animals, which statement is true for the use of CO2 as a euthanasia agent of mice?

Compressed CO2 gas in cylinders is the only recommended source of carbon dioxide.

Which of the following statements concerning confidentiality of IACUC business is false?

Confidentiality requirements prohibit IACUC members from reporting violations of the Animal Welfare Regulations (AWR) or PHS Policy.

Which of the following is a responsibility of each author?

Confirming that data have been accurately presented in the paper.

Which of the following is true about conflicts of interest?

Conflicts of interest increase the likelihood of bias.

Which of the following most accurately describes good mentoring practice?

Encouraging trainees to receive mentoring from a collection of individuals.

Which of the following is true regarding research misconduct?

Federal funding agencies typically rely on an institution to make the initial response to an allegation of research misconduct.

The main focus of NIH's conflict of interest policy is:

Financial conflicts of interest

Which of the following lists the required members of an IACUC constituted to comply with both the Animal Welfare Regulations (AWR) and PHS Policy?

Five members: chair, veterinarian, scientist, nonscientific member, and nonaffiliated member.

How long do employers need to keep the records for OSHA Bloodborne Pathogens Standard training?

For at least 3 years

Which statement is true regarding anesthesia in mice?

Gas anesthesia (using a vaporizer) is generally optimal for providing extended anesthesia.

Which of the following is the most effective strategy for preventing research misconduct?

Good mentoring

Which of the following statements is most accurate?

HBV vaccine is recommended for unvaccinated adults who are at risk for HBV infection.

Which of the following is the primary criterion for authorship?

Having made a significant intellectual contribution to the work.

Which is the best step to follow in the immediate aftermath of an occupational exposure incident to the eyes, nose, or mouth involving human blood or OPIM?

Immediately wash the exposed area with soap and water (or use an eye wash for 15 minutes) and then seek medical follow-up at the designated emergency healthcare location.

Which of the following statements is true regarding the International Committee of Medical Journal Editors (ICMJE) guidelines?

Individuals who do not meet the criteria for authorship but who have made a noteworthy contribution are normally listed in the acknowledgments section.

The two main criteria that the National Science Foundation (NSF) uses to evaluate grant proposals are:

Intellectual merit and broader impact.

What is the main function of a Technology Transfer Office with respect to collaborative research?

It helps collaborative researchers to commercialize their work.

What do the Animal Welfare Regulations (AWR) state about IACUC members who report violations to USDA?

It is against the law for anyone to discriminate against them or subject them to reprisals.

Which of the following most accurately describes a conflict of commitment?

It occurs when outside activities interfere with obligations to one's primary employer.

Which of the following best describes the required color and configuration of the universal biohazard symbol?

Labels should be fluorescent orange-red with lettering and symbols in a contrasting color.

Which of the following statements about attendance at IACUC meetings is false?

Like the Institutional Review Board (IRB), the IACUC cannot conduct business unless the member with nonscientific interests is present.

Which of the following is true about the management of conflicts of interest?

Management plans are often created to reduce the impact of conflicts of interest.

According to the U.S. Federal Research Misconduct Policy, falsification involves:

Manipulating research materials, equipment, or processes, or changing or omitting data.

Which of the following hinders an effective IACUC protocol review?

Members who are reluctant to express differing opinions.

Which of the following statements most accurately describes the mentoring relationship?

Mentors teach trainees about aspects of academic life that are not covered in textbooks.

Generally, there is no need to withhold food or water from mice before surgery because:

Mice are physiologically unable to vomit; they have no risk for respiratory aspiration of vomitus under anesthesia.

Which of the following is true regarding thermal support for mice during anesthesia?

Mice lose body heat rapidly under anesthesia.

With regard to conducting IACUC business, the definition of a quorum is:

More than fifty percent (a majority) of voting members.

Which of the following statements about IACUC members is true?

Nonaffiliated members must not utilize laboratory animals at any research facility.

Which of the following statements regarding routes of exposure to HBV is correct?

Percutaneous (through the skin) and mucous membranes (for example, splashes to the eyes, nose, and mouth) are the primary routes of exposure to HBV.

Which item is not considered PPE?

Personal identification badge

According to U.S. Federal Research Misconduct Policy, which of the following is considered to be research misconduct?

Plagiarism

Which of the following represents plagiarism?

Presenting someone else's ideas or words and claiming them as one's own.

Reviewers have a responsibility to promote ethical peer review by:

Preserving the confidentiality of the submission.

Which statement best describes what an IRB is responsible for reviewing?

Research involving a human subject

Which of the following statements is true regarding the responsibilities of reviewers?

Reviewers should identify the positive and negative aspects of a manuscript, and indicate where improvements are needed.

Which of the following is a true statement regarding engineering controls?

Sharps containers, biohazard bags, tongs, gauze pads, bench top shields, sealed tubes, and centrifuge safety buckets are all examples of other engineering controls that are available for worker protection.

Which of the following reflects the primary routes of exposure to bloodborne pathogens?

Skin or mucous membranes of eyes, nose, or mouth

Which of the following is a key reason why international collaborations can be challenging?

The collaborators may have different disciplinary and cultural backgrounds and practices.

Which of the following most accurately describes the process that must occur when working with research animals covered by U.S. federal regulations?

The research team must obtain IACUC approval for the proposed research procedures prior to starting the work.

What is the central focus of the OSHA Bloodborne Pathogens Standard?

The standard discusses a framework to minimize exposure to bloodborne pathogens (such as HIV, HBV, and HCV) that could be present in human blood, tissues, and body fluids.

Which of the following most accurately describes the responsibilities of a trainee in the mentoring relationship?

The trainee must take an active role in the relationship and clearly communicate needs and expectations.

Which of the following reflects an appropriate response to a spill involving human material and broken glass?

The worker must use a set of tongs or another device to collect the contaminated sharps.

What is the primary purpose of the "3Rs" concept from Russell and Burch?

To decrease the use of animals in research and to minimize pain and distress caused by animal experiments.

Which of the following best describes the purpose of the federally mandated "alternatives search" in an animal protocol?

To search for procedures that may replace the use of animals, reduce the number of animals used, or refine the methodology to minimize animal pain or distress.

Workers with occupational exposure to human blood, body fluids, and OPIM need training. Which of the following statements is correct regarding training for workers?

Training is required for occupationally exposed workers prior to the initiation of work involving exposure and annually within 365 days of the previous training.

Using appropriate personal protective equipment can reduce the risk of allergies to mouse urine and pelt proteins.

True

Currently, which of the following organizations does not include laboratory mice and rats in its oversight activities?

U.S. Department of Agriculture (USDA)

Which of the following statements best defines universal precautions?

Universal precautions are an infection control practice where all human blood or OPIM are treated as if they were infectious for HIV, HBV, HCV, and other bloodborne pathogens

In the research context, the term validity most commonly refers to:

Whether operationalized terms actually measure what they purport to measure.

Which statement is true regarding care procedures for mice undergoing surgery?

While under anesthesia, mice should be monitored for cardiovascular and respiratory function and body temperature.

Which of the following statements concerning health risks from working with mice is false?

Zoonotic diseases are very common in specific-pathogen-free laboratory mice.

Which of the following is a required training topic for occupationally exposed workers?

all of the above

Which of the following is commonly available in a basic spill kit?

all of the above

Before placing them in a bag in the necropsy freezer or cooler, you must make sure euthanized mice are really dead.

True

Which of the following is most likely to be considered plagiarism?

Using materials from a source without proper citation.

What is the recommended NIOSH height (in inches) for the top opening of wall mounted sharps containers?

52 to 56 inches

What is the current schedule for the administration of the HBV vaccination?

Currently, workers may need a two, three, or four dose series of the HBV vaccine depending on the vaccination.

Which of the following is true regarding data acquisition?

Data acquisition should follow a detailed collection plan that is set in advance.

Which of the following statements most clearly illustrates the principle of beneficence?

Determining whether the benefits of a study outweigh the risks.

A research collaboration can be enhanced by:

Discussing intellectual property issues while the collaboration is forming.

Which justification would an IACUC most likely accept if a research team plans to withhold pain relief (analgesia) from animals during a project?

Documented evidence that the analgesic agent will interfere with the aims of the project.

An IACUC that is not properly constituted:

Does not have required members appointed and cannot conduct official business.

Which entity is responsible for monitoring institutional compliance with PHS Policy?

The Office of Laboratory Animal Welfare (OLAW)

Which of the following is true regarding the use of animals in research?

The attending veterinarian must be allowed to have access to all research animals at all times.

Which of the following is the most appropriate step to take if authors believe that their manuscript was reviewed unfairly?

The author can contact the editor with their concerns.

Which of the following best summarizes the information that must be provided when a database search is used to document a lack of alternatives?

The names of the databases used, the date of the search, the years of citations accessed, and the search strategy.

Which of the following is most likely to own the data resulting from a research project?

The organization that receives federal funding for a project.

Which of the following is a recommended practice for sharps containers?

all of the above

What type container requires a label with the universal biohazard symbol?

all of the above