difference between apoptosis and necrosis
In apoptosis, no disintegration (swelling) of organelles . organelles remain intact
In necrosis, disintegration (swelling) of organelles
In apoptosis, aggregation of chromatin at the nuclear membrane
In necrosis, flocculation of chromatin
In apoptosis, there is formation of membrane bound vesicles (apoptotic bodies)
In necrosis, no vesicle formation. complete lysis
In apoptosis, phagocytosis is by adjacent cells or macrophages
In necrosis, phagocytosis is by macrophages only
In apoptosis, prelytic DNA fragmentation (early event of cell death)
In necrosis, poslytic DNA fragmentation (late event of cell death)
In apoptosis, non-random length fragmentation of DNA
In necrosis, random digestion of DNA
In apoptosis, integrity is preserved with blebbing of intact plasma membrane
In necrosis, there is loss of membrane integrity
pH of cell in Apotosis is acidic
pH of cell in Necrosis is unchanged
Apoptosis affects single cells
Necrosis affects groups of cells
Apoptosis is a tightly regulated process involving activation and enzyme steps
Necrosis involves loss of regulation of ion homeostasis
Apoptosis is a neat and organized process
Necrosis is a messy process
Apoptosis is an active process, does not occur at 4 degree celcius)
Necrosis is a passive process, occurs at 4 degree celcius)
Apoptosis is caspase dependent
Necrosis is caspase independent
Apoptosis is energy (ATP)- dependent
Necrosis is energy independent (ATP not required)
Apoptosis is induced by physiological disturbances
Necrosis is evoked by non-physiological disturbances
Apoptosis has no inflammatory response
Necrosis leads to inflammation