difference between apoptosis and necrosis

In apoptosis, no disintegration (swelling) of organelles . organelles remain intact

In necrosis, disintegration (swelling) of organelles

In apoptosis, aggregation of chromatin at the nuclear membrane

In necrosis, flocculation of chromatin

In apoptosis, there is formation of membrane bound vesicles (apoptotic bodies)

In necrosis, no vesicle formation. complete lysis

In apoptosis, phagocytosis is by adjacent cells or macrophages

In necrosis, phagocytosis is by macrophages only

In apoptosis, prelytic DNA fragmentation (early event of cell death)

In necrosis, poslytic DNA fragmentation (late event of cell death)

In apoptosis, non-random length fragmentation of DNA

In necrosis, random digestion of DNA

In apoptosis, integrity is preserved with blebbing of intact plasma membrane

In necrosis, there is loss of membrane integrity

pH of cell in Apotosis is acidic

pH of cell in Necrosis is unchanged

Apoptosis affects single cells

Necrosis affects groups of cells

Apoptosis is a tightly regulated process involving activation and enzyme steps

Necrosis involves loss of regulation of ion homeostasis

Apoptosis is a neat and organized process

Necrosis is a messy process

Apoptosis is an active process, does not occur at 4 degree celcius)

Necrosis is a passive process, occurs at 4 degree celcius)

Apoptosis is caspase dependent

Necrosis is caspase independent

Apoptosis is energy (ATP)- dependent

Necrosis is energy independent (ATP not required)

Apoptosis is induced by physiological disturbances

Necrosis is evoked by non-physiological disturbances

Apoptosis has no inflammatory response

Necrosis leads to inflammation