Manufacturing Pharmacy (BLUE)

Which of the following is NOT used in the formulation of Honey and Almond Cream? a. White wax b. Carnation oil c. Stearic acid d. Potassium carbonate

A

Which of the following is an example of a soft gel capsule? a. Squibb b. Amoxicillin c. Flanax Forte d. Ponstan SF

A

Which of the following is frequently used as a peel strip for transdermal patches? a. Polyesters b. Acrylic c. Silicone d. Polyisobutylene e. Starch

A

Which of the following is frequently used as a sweetening agent in the formulation of toothpaste? a. Saccharin b. Calcium carbonate c. Glycerin d. Wintergreen

A

Which of the following is used as a clarifying agent in the formulation of shampoos? a. Terpineol b. Citric acid c. Selenium disulfide d. Behenic acid

A

Which of the following is used as flower oil in the formulation of fragrances? a. Jasmine absolute b. Clove oil c. Myrrh d. Cinnamon oil

A

Which of the following statement is NOT true? a. Geometric dilution is not necessary for incorporation of small amounts of potent drug. b. Sieving is necessary to achieve mixing or reduction of agglomerates. c. Powders must be protected against humidity, air oxidation, and loss of volatile ingredients. d. Divided powders are dispersed in the form of individual doses and packed in papers properly folded.

A

___________ tablets are tablets with a coating that resists dissolution in the stomach but not in the intestines. a. Enteric coated b. Sugar coated c. Film coated d. Effervescent e. Sublingual

A

_______________ creams softens the skin. a. Emollient b. Cleansing c. Shaving d. Suntan

A

_________________ capsule is made from the mixture of gelatin, sugar and water with or without suitable coloring agents. a. Hard b. Soft c. Either A or B d. None of the above

A

__________________ for Injection USP is intended to be used within 24 hours following its collection. a. Water b. Purified Water c. Sterile Water d. Bacteriostatic Water

A

For a dry granulation process, given that the weight of all ingredients is 104 grams and the batch size is 400 tablets, what is the average tablet weight? a. 385 mg b. 260 mg c. Insufficient data d. None of the above

B

Hair like string inside the bottle. a. Overpress b. Filament c. Check d. Split

B

Humectant is one of the basic ingredients of a mouthwash. Its usual concentration is a. 5-25% b. 5-20% c. 10-20% d. 10-25%

B

It is a hydrocarbon base utilized as a vehicle in the compounding of semisolid preparations. And it spreads easily on the skin. a. Vanishing cream b. Petroleum c. Lanolin d. Cholesterol

B

It is defined as a process that tends to result in a randomization of dissimilar particles within a system a. Blending b. Mixing c. Filtration d. Homogenization

B

It is the major concern with regards to the physical stability of the solutions a. Dissolution b. Precipitation c. Microbiological stability d. Compatibility

B

It is the purified honeycomb of the bee. It contributes to cream consistency. a. Mineral oil b. Beeswax c. Cetyl alcohol d. Cocoa butter

B

Mannitol when used in parenterals acts as a. Solubilizer b. Isotonicity adjuster c. Antioxidant d. Preservative

B

Mechanism of action of dry heat sterilization is by a. Coagulation of cellular protein b. Oxidation c. Sieving d. Alkylation

B

Mechanism of action of oven for sterilization a. Coagulation of cellular proteins b. Oxidation c. Alkylation d. Lethal mutation

B

Method that will produce tablets of best quality. a. Direct compression b. Wet granulation c. Dry granulation d. AOTA

B

Minimum requirement for efficiency of HEPA filter a. 99.99% effective against 0.3 microns b. 99.97% effective against 0.3 microns c. 99.97% effective against 0.5 microns d. 99.99% effective against 0.2 microns

B

Mouthwash is an example of a. Oral solution b. Topical solution c. Otic solution d. Nasal solution

B

Nitrogen and carbon dioxide are examples of _________. a. Synergist b. Oxygen displacer c. Reducing agent d. Blocking agent

B

Ointment base which allows absorption of serous discharges a. Hydrocarbon base b. Absorption base c. Water-removable base d. Water-soluble base

B

One of the economic considerations regarding processing in the selection of mixers includes a. Miscibility b. Processing time c. Maintenance d. Cost of equipment

B

Packaging and storage of sterile water for injection a. Type III glass containers, single dose b. Type II glass, single dose c. Type III glass, multiple dose d. None of the above

B

Partial fractures generally found in the hell area, but sometimes occurring at the shoulder. a. Soft blister b. Cracks c. Stone d. Mismatch

B

Particle size can be influenced by the following factors, EXCEPT: a. Penetrability of particles intended to be inhaled for deposition deep in the respiratory tract b. Grittiness of solid particles c. Uniform distribution of a drug substance d. Suspendability of particles intended to remain undissolved but uniformly dispersed in liquid vehicle

B

Presence of an oily film or droplets of liquid on the surface of the coat which may indicate incompatibilities in the film. a. Blistering b. Sweating c. Orange peel d. Wrinkling

B

Pressurized dosage forms that upon actuation emit a fine dispersion of liquid and/or solid materials containing one or more active ingredients in a gaseous medium are known as a. Inhalations b. Aerosols c. Sprays d. Inhalants

B

The following quality control tests apply to both hard gel and soft gel capsules, EXCEPT: a. Disintegration test b. Moisture permeation test c. Content uniformity d. Dissolution test

B

_________________ are small, fine cracks observed on the upper and lower central surface of tablets, or very rarely on the sidewall. a. Chipping b. Cracking c. Mottling d. Lamination

B

Transdermal delivery system used for the treatment of angina. a. Estradiol b. Glyceryl trinitrate c. Nicotine d. Hyoscine e. None of the above

B

Type of mill used for the reduction of solid particle size and for dispersion of suspensions containing poorly wetted solids a. Hammer b. Rotor stator c. Impact d. Fluid-energy

B

Types of glass used for buffered aqueous solution with pH below 7.0 a. Type I glass b. Type II glass c. Type III glass d. NP

B

Unclean clothing can contribute to a. Cross contamination b. Particulate contamination c. Mix-ups d. Microbial contamination

B

Used for mixing powder mixtures in large volume quantity a. Drum roller b. V-blender c. Planetary mixer d. Compactor mills

B

_________________ is due to rapid expansion of tablets when deep concave punches are used. a. Lamination b. Cracking c. Capping d. Binding

B

_________________ is the separation of a tablet into 2 or more distinct horizontal layers. a. Picking b. Lamination c. Sticking d. Chipping

B

__________is a blend of fragrant complexes culminating in an intense heavy full-bodied fragrance. a. Cologne-blend b. Oriental c. Bouquet d. Floral

B

Wet granulation a. Always requires both a solvent and a binder or an adhesive b. Always requires a solvent c. Always requires a binder or adhesive d. All of the above

B

What is the therapeutic use of acetaminophen? a. Diuretic b. Analgesic c. Expectorant d. Dietary supplement

B

What is the use of lactose in the formulation of Acetaminophen tablet? a. Binder b. Diluent c. Disintegrant d. Lubricant

B

When the ________is depressed the aerosol will deliver a spray precise volume. a. Propellant b. Valve c. Actuator d. Dip tube e. Container

B

Which of the following ingredient is not present in hard gelatin capsule? a. Diluent b. Binder c. Lubricant d. Disintegrant

B

Which of the following is NOT a characteristic of water soluble bases that are used in the formulation of ointment? a. It is composed of many polar group b. Water is required for their preparation c. It is also called greaseless ointment base d. It softens or melts when applied to the skin e. It is composed of many ether linkages

B

Which of the following is NOT a compressed gas? a. Nitrogen b. Butane c. Nitrous oxide d. Carbon dioxide

B

Which of the following is used as a preservative I the formulation of Aluminum Hydroxide Gel, USP? a. Aluminum hydroxide b. Sodium benzoate c. Sodium saccharin d. Distilled water

B

Which of the following is used as an opacifying agent in the formulation of shampoos? a. Lauric acid b. Behenic acid c. Propylene glycol d. Lanolin

B

Which of the following is used to minimize the foam in the production of emulsion? a. Spans b. Cetyl alcohol c. Tweens d. Acacia

B

Xanthan gum, as flocculating agent, is classified under a. Surfactant b. Hydrophilic polymer c. Clay d. Electrolyte

B

________ are powders agglomerated to produce larger free-flowing particles. a. Tablets b. Granules c. Capsules d. Suppository e. Ointment

B

______________ is used primarily to reduce the solid particle size and for the dispersion of suspension containing particles. a. Mechanical stirrers b. Colloid mills c. Homogenizer d. Ultrasonifier

B

_______________ is used in the formulation of face powder because it provodes water proofing properties. a. Silicate b. Zinc stearate c. Magnesium carbonate d. Calcium carbonate

B

_______________ stiffens a cream. a. Spermaceti b. Ceresin c. Lanolin d. Beeswax

B

________________ are solid dosage forms in which the drug is enclosed in either a hard or a soft, soluble shell of a suitable form of gelatin. a. Tablets b. Capsules c. Ointments d. Solutions

B

A volume of about 0.1 mL is injected into the skin between the epidermis and the dermis a. Intramuscular b. Intravenous c. Intradermal d. Intra-arterial e. Intra cardiac

C

Agents that can neutralize carbomer includeI. NaOH II. KOH III. Polar Organic Amines IV. Strong Electrolytes a. I only b. I and II c. I, II and III d. III only

C

A preservative used in ophthalmic and nasal preparation is a. Boric acid b. Methyl paraben c. Cetylpyridinium chloride d. Phenol

C

A step in tablet sugar coating that involves the application of syrup concentrate to build up slid color rapidly. a. Subcoating b. Regular syruping c. Heavy syruping d. Grossing

C

A sunken center portion at the bottom of the bottle. a. Soft blister b. Freaks c. Rocker bottom d. Poor distribution

C

A tamper-evident packaging where a band is shrunked by heat or dried to conform to cap is the a. Bottle seal b. Strip pack c. Shrink seal d. Tape seal

C

One good reason for inspecting the quality of the product during packaging and labeling operation is a. To prevent mix-ups and errors b. To monitor uniform labeling c. To ensure approval of the product d. To allow ease of reconciliation

D

Products that are prone to decomposition by moisture generally are packed with a a. Tight container b. Vacuum seal c. Absorbent cotton d. Dessicant packet

D

Pyrogens are produced by a. Gram negative bacteria b. Gram positive bacteria c. Fungi d. All of the above

D

Republic Act No. 6675 is known as a. Pharmacy Law b. Food, Drugs, and Cosmetics Act c. Narcotic Drug Regulation d. Generics Act of 1988

D

Route of administration of parenterals or injections that provide effects that are less rapid bur generally longer lasting is the a. Intradermal route b. Subcutaneous route c. Intravenous route d. Intramuscular route

D

Small inclusion of any non-glass material. a. Mismatch b. Fin c. Pinhole d. Stone

D

The attire or uniform used in parenteral production include a. Cover-all b. Facemasks c. Boots and gloves d. All of the above

D

The container of choice for ointments. a. Plastics b. Glass c. Wide mouth bottle d. Collapsible tubes

D

The following are FD&C certified red dyes that exhibit good stability in the presence of light, acid, and alkali preparation, except a. FD&C Yellow #5 b. FD&C Yellow #6 c. FD&C Red #40 d. FD&C Blue #4

D

The following are classified under suspension, except a. Gels b. Lotions c. Magmas and milk d. Liniments

D

The following are examples of common product complaints, EXCEPT: a. Misbranding b. Adulteration c. Counterfeit d. Elegance

D

The following are functional categories if triethanolamine, except a. Alkalizing agent b. Emulsifying agent c. Solubilizing agent d. Suspending agent

D

The following are suspending agents on suspension formulations, EXCEPT: a. Tween 80 b. Carbopol c. Methocel d. Gelatin

D

The following are true for production areas for pharmaceuticals, except a. Access is restricted to authorized personnel b. Non-medicinal products should not be produced c. Provisions should be made for proper air control d. Performance of in-process controls is prohibited

D

The test done for parenterals for the presence of bacterial endotoxins is the a. Sterility test b. Pyrogen test c. Rabbit test d. Limulus Amebocyte Tests

D

The type of suspension system in which the particles settles as a dense sediment is called a. Flocculated system b. Colloidal system c. Coagulated system d. Deflocculated system

D

They are known as greaseless ointment bases. a. Hydrocarbon bases b. Absorption bases c. Water removable bases d. Water soluble bases

D

To make a solution of a solid in a solvent, the concentration of the solid in the solvent I. Must be below the solubility of the solid in that solvent II. Must be above the solubility of the solid in that solvent III. Must be at the solubility of the solid in that solvent a. I only b. II only c. I and II d. I and III

D

Type of mill used for tough, fibrous materials a. Hammer mill b. Ball mill c. Roller mill d. Cutting mill

D

The following are the usual criteria and standards for raw materials specifications, EXCEPT: a. Refractive index b. Crystal shape c. Authenticity d. Identification

C

The following can avoid cross contamination, except a. Conducting campaign production b. Recirculating of air c. Wearing protective clothing d. Using cleanliness status labels

C

The relative intensity of a fragrance impression. a. Dry out b. Body c. Strength d. Thin

C

The sweetening agent employed to impart sweetness to chewable tablets is a. Dextrose b. Saccharin Sodium c. Mannitol d. Sucrose

C

The term that describes dosage forms having drug release features based on time, course, and/or location that are designed to accomplish therapeutic or convenience objectives not offered by conventional forms is a. Repeat Action b. Extended Release c. Modified Release d. Delayed Release

C

What is the appropriate capsule size for 0.65 to 1.82 materials? a. 3 b. 1 c. 000 d. 0

C

What is the largest capsule size? a. 5 b. 1 c. 000 d. 0

C

What is the use of sorbitol in the formulation of Aluminum Hydroxide Gel, USP? a. Sweetener b. Flavorant c. Viscosity builder d. Vehicle

C

What is the use of starch paste on the formulation of Acetaminophen tablet? a. Colorant b. Flavorant c. Binder d. Lubricant

C

Biological characterization of new drugs involve the following studies, EXCEPT: a. Pharmacology b. Physical pharmacy c. Toxicology d. Pharmacokinetics

D

A suspending agent that requires a high speed equipment and which is suitable for internal and external use a. Carbomer b. Bentonite c. Sodium alginate d. Tragacanth

A

Odd shapes and conditions that render the container completely unusable. a. Freaks b. Cracks c. Stone d. Splits

A

Heavy glass on one side of the bottle. a. Mark b. Stuck c. Long neck d. Heel tap

D

Which of the following is NOT a blocking agent? a. Sodium metabisulfide b. Butyl hydroxytoluene c. Ascorbic acid esters d. NOTA

A

A special quality control test done for suspensions to measure the degree of air entrapped is called a. Specific gravity b. Coulter counter c. Photomicroscopy d. Physical stability

A

Which of the following is NOT classified as a lubricant? a. Lactose b. Talc c. Stearic acid d. Calcium stearate

A

. Before a medicinal agent is formulated into one or more dosage forms, the following therapeutic matters are considered, EXCEPT: a. Gender b. Manner of treatment(local or systemic) c. Nature of illness d. Age

A

A major process by which foreign substances, including drugs, are eliminated from the body is called a. Metabolism b. Distribution c. Absorption d. Liberation

A

A non-greasy emulsion base with pH close to that of the skin is the a. Unibase b. Hydrophilic Petroleum c. Lanolin d. Dermovan

A

A suspension of a drug that can be formulated for topical application is a. Calamine Lotion b. Oxytetracycline Suspension c. Chloramphenicol palmitate suspension d. Prednisolone suspension

A

A wavy condition of horizontal lines in the body of the bottle. a. Washboard b. Hard blister c. Seeds d. Tear

A

Ascorbic acid is classified as ______________. a. Reducing agent b. Blocking agent c. Chelating agent d. Oxygen displacer

A

Carbomer, as suspending agent, has a usual concentration of a. 0.5-1.0% b. 0.5-2.0% c. 0.1-0.5% d. 0.5-1.5%

A

Coating process/es which serves to separate the tablet core from the water a. Seal coat b. Subcoat c. Syrup coat d. All of the above

A

Dehydrogenation may be done by the following methods, EXCEPT: a. Heating at 240C for 30 minutes b. Boil with strong acid c. Reverse osmosis d. Distillation

A

Determination of moisture for effervescent tablets is conducted through: a. Paar calorimeter b. Karl Fisher method c. Loss on drying d. Azeotropic method

A

Drug delivery systems that facilitate the passage of therapeutic quantities of drug substances through the skin by means of percutaneous absorption and into the general circulation for systemic effects. a. Transdermal drugs b. Cream patches c. Medicated plasters d. Tablets

A

EDTA is classified as ________________. a. Chelating agent b. Synergist c. Blocking agent d. Oxygen displacer

A

Excipient used to prevent the drying of preparations, particularly ointments and creams is called a. Humectant b. Vehicle c. Plasticizer d. Solvent

A

Frequently employed method in the manufacture of ointments wherein the active ingredient is mixed with the melted waxes and base. a. Fusion method b. Punch method c. Dry granulation d. Levigation

A

Hard gelatin capsules contain ______% of water a. 12-16 b. 10-20 c. 0.1-1 d. 1-10

A

In adults, what is the common site for intramuscular injection? a. Gluteals b. Deltoid c. Abdomen d. Pectoralis e. Thigh

A

In case of coated tablets, it is a film defect caused by rapid drying or inadequate solution after each application of coating solution a. Blistering b. Sweating c. Orange peel d. Wrinkling

A

It establishes the objectives and determines the basic policies and the general courses of the business. a. Level I b. Level II c. Level III d. NOTA

A

It functions to investigate customer complaints or inquiries on product quality. a. Central release section b. Chemical control section c. Inspection and checking section d. Specification/Assay Dev. Section

A

It is added in hard gel capsule to prevent decomposition during manufacture. a. Sulfur dioxide b. Titanium dioxide c. Glycerin d. Sorbitol

A

It is employed to allow the displacement of air from hydrophobic materials and permit the continuous liquid phase to surround the particles a. Wetting agent b. Suspending agent c. Flavoring agent d. Flocculating agent

A

It is frequently used as a diluent in the formulation of chewable tablet. a. Mannitol b. Celutab c. Avicel d. Lactose e. Sucrose

A

It is used as an antioxidant in the compounding of semisolid preparations. a. Butylated hydroxyl toluene b. Parabens c. Sorbitan monostearate d. Mineral oil

A

Largest capsule size. a. 000 b. 0 c. 5 d. 1

A

Limits of bacterial endotoxin of sterile water for injection a. Less than 0.25 USP Endotoxin Unit per mL b. Less than 0.25 USP Endotoxin Unit per 100 mL c. Less than 0.50 USP Endotoxin Unit per mL d. Less than 0.20 USP Endotoxin Unit per mL

A

Magnesium stearate should be present in not more than 1% w/w of the formulation because a. An increase in disintegration time results beyond this limit b. A decrease in disintegration time results beyond this limit c. Granules become too flowable beyond this limit d. None of the above

A

Mechanism of action of saturated steam under pressure a. Coagulation of cellular proteins b. Oxidation c. Alkylation d. Lethal mutation

A

Method of preparing sodium chloride tablet. a. Direct compression b. Granulation by compression c. Wet granulation d. Spray drying e. Slugging

A

One of the following situations can avoid cross contaminations and mix-ups. a. Components are tightly sealed. b. Improper partitioning of working areas. c. Components are improperly dispersed. d. Wrong label

A

Opacifying agent used in the production of opaque hard gelatin capsules a. Titanium dioxide b. Titanium oxide c. Zinc oxide d. Lactose e. Starch

A

Process employed both to comminute and mix powders is called a. Trituration b. Blending c. Spatulation d. Levigation

A

Quarantined materials delivered in the warehouse are a. Subject to test and assay b. Releasable to production department c. Rejectable d. In-process products

A

Small bubbles in the glass. a. Seeds b. Stuck c. Tear d. Mark

A

Solid preparations made up of sodium bicarbonate, citric acid, and tartaric acid are referred to as a. Effervescent granules b. Bulk powder c. Divided powder d. Aerosol granules

A

The basic tool that clearly defines the authority, duty or responsibility of the areas in the chart is the a. Position description b. Organizational planning c. Organizational manual d. Chart description

A

The best solvent used for the preparation of oral liquid dosage forms is a. Purified Water, USP b. Sterile Water for Injection, USP c. Distilled Water, USP d. Mineral Water

A

The color of amber glass is produced largely by the presence of: a. Iron oxide b. Titanium dioxide c. Magnesium oxide d. Silicon dioxide

A

The common name for FD & C Red #2 a. Amaranth b. Erythrosine c. Ponceau SX d. Carmine

A

The following animals may be used in evaluating the toxicity plastic materials based on USP test procedures EXCEPT: a. Dogs b. Rabbits c. Mice d. None of the above

A

The following are characteristics of flocculates system of suspensions, EXCEPT: a. The sediment is formed slowly b. The flocculated suspensions exhibit plastic or pseudo plastic behavior c. Particles in the suspension are in the form of loose agglomerates d. The sediment is easily redispersed by small amount of agitation

A

The following are methods of sterilization for parenteral products, EXCEPT: a. Steam sterilization b. Boiling c. Filtration d. Gas sterilization

A

The following are natural emulsifying agent EXCEPT a. Tween 80 b. Acacia c. Agar d. Gelatin

A

The following are penetration enhancers, except a. Carbomer b. Glycerin c. Propylene glycol d. Water

A

The following are the methods used for the preparation of suppositories, EXCEPT: a. Congealing b. Hand rolling c. Fusion d. Compression

A

The following qualities are tested for containers, EXCEPT: a. Breakability b. Drug compatibility c. Toxicity d. Light transmission

A

The information that gives an indication of particle size and size range of the raw material along with the crystal structure is the a. Microscopic examination b. Physical description c. Particle size d. Solubility

A

The most efficient type of motion in sieving a. Vibratory b. Rotary c. Side-tap d. Bottom-tap

A

The process of reducing substances to fine particles by rubbing them in a mortar with pestle. a. Trituration b. Pulverization by intervention c. Levigation d. Fusion

A

The required amount of methyl and propyl paraben combinations as preservatives employed in pharmaceutical products is a. 0.1-0.2% b. 0.1-0.5% c. 15-20% d. 0.002-0.01%

A

The section responsible for the conduct of stability studies is the a. Chemical control and testing section b. Central release section c. Assay and specification section d. Inspection and checking section

A

The weight requirement for a rectal suspension contains a. 2 g b. 1g c. 4g d. 5g

A

These are gas sterilants EXCEPT a. Carbon Dioxide b. Formaldehyde c. Beta propiolactone d. Sulfur dioxide

A

Which of the following is NOT considered in the preparation of pharmaceutical solutions? a. Chemical modification b. Absorption or penetration c. Stability d. Solubility

A

To prevent microbial contamination contributed by people, it is best to a. Practice good personal hygiene b. Tolerate injuries and illness c. Clean equipment properly d. Conduct quality control test

A

Type of surfactant preferred for sensitive skin a. Amphoteric b. Nonionic c. Cationic d. Anionic

A

What capsule size has the approximate capacity of 0.098 to 0.13g of materials? a. 5 b. 4 c. 2 d. 3

A

What gives calamine its characteristic pink color? a. Zinc oxide b. Ferric oxide c. Lead oxide d. Hydrogen sulfide e. Lead sulfide

A

What is the common method employed by a pharmacist in filling of capsules? a. Punch method b. Ouch method c. Dry gum method d. Hunch method

A

What is the effect on the tablet formulation if too much binder is added? a. Tablet produced will be coarse and dry b. Larger quantity of lubricants will be required to facilitate tablet ejection c. Premature dissolution of active ingredient may occur particularly when wet binders are used d. Mottling of tablet surfaces may occur for colored granules e. None of the above

A

What is the positive result for Bacterial Endotoxin Test? a. Gel-clot formation b. White precipitate c. Green solution d. Blue solution

A

What is the smallest capsule size? a. 5 b. 1 c. 000 d. 0

A

What is the therapeutic use of Soda Mint Tablet? a. Antacid b. Astringent c. Antifungal d. Keratolytic

A

. The ability of a particular formulation in a specific container to remain within its physical, chemical, therapeutic and toxicological specification is called a. Overage b. Shelf-life c. Validation d. Stability

B

. _________________ is the term used, when the upper or lower segment of the tablet separates horizontally, either partially or completely from the main body of a tablet and comes off a cap, during ejection from the tablet press, or during subsequent handling. a. Lamination b. Capping c. Picking d. Binding

B

A dilute concentration of suspension contains a. 1-5% (w/v) solids b. 2-10% (w/v) solids c. 10-50% (w/v) solids d. 50% (w/v) solids

B

A disadvantage of parenterals is a. It needs to be administered by a professionally trained person b. Difficulty in correcting error c. Not recommended for patients who cannot take oral medications d. It has immediate and controlled physiological effects

B

A natural gum best used as a tablet binder when dry since it is difficult to disperse and forms a very heavy mucilage in water. a. Acacia b. Tragacanth c. Gelatin d. Alginic acid

B

A very simple, sensitive, and fast test for pyrogens using the amebocyte of te horseshoe crab. a. Pyrogent test b. LAL test c. Rabbit test d. Crab test

B

Advantages of plastic containers over glass, EXCEPT: a. Lightness in weight b. Permeability c. Lower cost d. Resistant to impact

B

Aggregates of powders which adhere or bond to each other to form larger particles. a. Powders b. Granules c. Microcapsules d. Pellets

B

All of the following glass types may be subjected to the Powdered Glass Test except: a. Highly resistant borosilicated glass b. Treated soda-lime glass c. Soda-lime glass d. General purpose soda lime glass

B

An agent that "glue" powders together and cause them to form granules is the a. Diluent b. Binder c. Glidant d. Disintegrant

B

An establishment which is a registered owner of the drug product, procures the materials and packaging components and provides the production monograph and quality control standards and procedures is the a. Drug importer b. Drug trader c. Drug supplier d. Drug manufacturer

B

An example of a base that is washable in water and absorbs water is a. Cold cream b. PEG Ointment c. Vanishing cream d. Hydrous woolfat

B

An important parameter considered for the stability of drug products is a. Loss of elegance b. Increase in potency c. Loss of moisture content d. Loss of activity

B

An ointment base which is anhydrous, water-insoluble and cannot absorb water is a. Absorption base b. Oleaginous base c. Emulsion base d. Water-soluble base

B

Carbomer, as a gelling agent, has a usual concentration of a. 0.5-1.0% b. 0.5-2.0% c. 0.1-0.5% d. 0.5-1.5%

B

Classification of temperature between 8C and 15C a. Cold b. Cool c. Controlled room temperature d. Warm e. None of the above

B

Cold sterilization refers to the removal of particulate matter down to the smallest size of a. 2 microns b. 0.2 microns c. 0.3 microns d. 0.5 microns

B

Retention period for finished products should be a. At least 2 years after the distribution of the first lot b. One year after the expiration date of the product c. At least 3 years after the manufacture is completed d. At least 1 year after the expiration date of the last lot

B

Separation of the tablet into two or more distinct layers are called a. Capping b. Lamination c. Blistering d. Flaking

B

Stage of research which involves manufacturing requirements, reviews basic information, product control and patent application is the a. Applied Research Stage b. Clinical Research Stage c. Pharmaceutical Research Stage d. Preliminary Research Stage

B

Substances used to cause adhesion of powder particles in tablet granulations are called a. Disintegrants b. Binders c. Diluents d. Glidants

B

Suspension adjunct used to prevent the product from drying at topical application. a. Sweetening agent b. Humectant c. Preservative d. Emollient

B

Tablet defect which may be revealed through the friability test or by shaking tablets vigorously in cupped hands. a. Sticking b. Lamination c. Picking d. Double impression

B

The ___________________ come in contact with both the product and the propellant and therefore should be resistant to both physical and chemical attack. a. Valve b. Dip tube c. Actuator d. Container e. Propellant

B

The best solvent to use for oral solutions is the a. Diluted Alcohol, USP b. Purified Water, USP c. Propylene Glycol d. Alcohol, USP

B

The color for quarantine sticker is a. Green b. Yellow c. White d. Red

B

The following are characteristics of gels, except a. Water washable b. Occlusive c. Can absorb additional water d. Lipid-free

B

The following are examples of true antioxidant except a. BHA b. Lecithin c. BHT d. Tocopherols

B

The following are important document in the manufacture of drugs and cosmetics, EXCEPT: a. Manufacturing monographs b. Batch records c. CGMP guidelines d. Standard operating procedures

B

The following are tests that evaluate the flammability and combustibility of pharmaceutical aerosols except: a. Flash point b. Vapor pressure c. Flame extension d. Closed drum test

B

The organizational chart can a. Reveals little about working relationships b. Assess strength and weaknesses in functions and personnel c. Indicate delegated authority d. Reveal company objectives and policies

B

The period in which the product remain acceptable for use. a. Stability b. Shelf life c. Accelerated stability studies d. All of the above

B

The rapid formation of aggregates of emulsion droplets is called a. Precipitation b. Coalescence c. Aggregation d. Flocculation

B

The section which samples retention or reserved samples withdrawn from the packaging line for FP's and from the warehouse for the RM's. a. Chemical control section b. Inspection and checking section' c. Technical/QC section d. Central release section

B

The specification and Assay Development Section is under the a. Central release section b. Technical director's department c. Chemical control section d. Inspection/checking section

B

These are compounds that increase the effectiveness of antioxidants, particularly by blocking oxidative reactions. a. Blocking agents b. Synergist c. Chelating agent d. Reducing agent

B

These are excipients composed of inorganic materials which are used to provided added hiding or covering power to tablet coating solutions: a. Colorants b. Opaquant-extenders c. Plasticizers d. Lakes

B

This type of excipient must be added when lactose is used as a diluent in tablet manufacture. a. Glidant b. Lubricant c. Anti-adherents d. Buffers

B

. Which of the following is NOT used as a humectant I the formulation of tooth paste? a. Glycerine b. Sorbitol c. Dichlorphene d. Propylene glycol

C

A homogenous mixture of one or more solute dissolved or molecularly dispersed in a solvent is called a. Emulsion b. Syrup c. Solution d. Suspension

C

A mechanism for determining and assigning necessary duties to people so they can work together effectively is the a. Chart b. Quality rules c. Organization d. Management

C

An example of non-aqueous solution is a. Spray b. Juice c. Oleovitamin d. Douche

C

An inert filter that creates the desired bulk, flow properties, and compression characteristics of tablets and capsules is called a. Lubricant b. Surfactant c. Diluent d. Anti-adherents

C

Aspilet tablets for children are a. Sublingual b. Buccal c. Chewable d. Soluble

C

Dry granulation is used for active ingredients which are a. Prone to solvent degradation b. Unstable in heat and drying process c. Either a or b d. None of the above

C

Film coating defect that occurs as a consequence when products are processed under exceedingly humid conditions a. Spotting b. Blistering c. Bloom d. Orange peel

C

HEPA filters are used for the filtration of a. Parenterals b. Ophthalmics c. Air d. Solvents

C

In the formulation of liquids, the following consideration should be studied, EXCEPT: a. Availability b. Viscosity c. Organoleptic characteristics d. Stability

C

In wet granulation, the proper amount of binder should be added because a. Insufficient wetting will result to hard granules b. Over wetting will result to soft granules c. Overly wet materials would prolong processing d. Both A and B

C

It can be applied to moist skin lesions because it can absorb discharges. a. Hydrocarbon bases b. Absorption bases c. Water removable bases d. Water soluble bases

C

It is composed of magnesium trisilicate. It is the basic ingredients of all powder formulations. a. Magnesium carbonate b. Calcium carbonate c. Talc d. Kaolin

C

Materials which help the tablet break up and dissolve to release the medicament are called: a. Anti-adherents b. Solubilizing agents c. Disintegrants d. Diluents

C

Mechanism of action of ethylene oxide gas for sterilization a. Coagulation of cellular proteins b. Oxidation c. Alkylation d. Lethal mutation

C

Metallic strearates are usually passed through fine mesh screens before mixing with the granules to a. Increase their covering power b. Reduce the amount required c. Both a and b d. None of the above

C

Methods used for the incorporation of small amounts of potent drugs with a large amount of diluent. a. Spatulation b. Sifting c. Geometric dilution d. Levigation

C

Milling of dry ingredients is done to a. Facilitate uniform blending in the mixing step b. Remove or break lumps c. Both a and b d. None of the above

C

Standard Operating Procedures are written for the following operations EXCEPT a. Calibration of equipment b. Receipt of materials and records c. Consumer's information records d. Recall procedures

C

Substance that glue powders together that cause them to form granules. a. Diluent b. Lubricant c. Binder d. Disintegrant

C

Tablets that are flat and oval which are intended to be dissolved beneath the tongue are called a. Effervescent tablets b. Molded tablets c. Sublingual tablets d. Buccal tablets

C

Tablets that are prepared by subjection to more than a single compression are called a. Enteric-coated tablets b. Film-coated tablets c. Multiple compressed tablets d. Molded tablets

C

The ______________ come in contact with both the product and the propellant. a. Propellant b. Valve c. Dip tubes d. Actuator

C

The ______________ is responsible for developing the proper pressure within the container and it expels the product. a. Valve b. Dip tubes c. Propellant d. Actuator

C

The basic element of an organization where the types of work must be identified and grouped logically on related elements is the a. Delegation of authority b. Determination of interrelationship among functions c. Division of responsibility d. None of the above

C

The following tests official in USP/NF except: a. Pyrogen test b. Sterility test c. Clarity test d. Bacterial endotoxin test

C

The hydrocarbon base which is frequently used as a vehicle for ointment. a. Cholesterol b. Lanolin c. Petroleum d. Sorbitan monostearate monooleate e. Mineral oil

C

The main concerns for the formulation of suspensions are the following, EXCEPT: a. To eliminate separation on standing b. To create the required particle size c. To decrease rate of settling d. To permit easy resuspendability

C

The management guide which combine the chart and position description is considered as the a. First basic tool b. Second basic tool c. Third basic tool d. Fourth basic tool

C

The method of mixing or blending small amounts of powders by movement of spatula through them on a sheet of paper or ointment slab is called a. Levigation b. Comminution c. Spatulation d. Trituration

C

The period of stability of a preparation is the time from the date of manufacture until its chemical or biological activity a. Has deteriorated b. Is close to 100% c. Is not less than 90% of the labeled potency d. Has reached its maximum

C

Which of the following id NOT used as a perfume in the formulation of Honey and Almond Cream? a. Benzaldehyde b. Rose oil c. Coconut oil d. Carnation oil

C

Which of the following is NOT a physical property of a solution? a. Clarity b. Odor c. Vehicle d. Viscosity

C

Which of the following is NOT true about autoclave? a. It makes use of moist heat. b. It is considered a thermal process of sterilization. c. It is considered as a chemical process of sterilization. d. It is considered as a physical process of sterilization.

C

Which of the following is NOT true about the flocculated system of suspension? a. It forms a clear particle free supernatant liquid and sediment. b. Particles appear as floccules. c. It frequently results in a poor suspension. d. It exhibits a minimum of serious separation.

C

Which of the following is NOT used as a preservative in parenteral preparations? a. Benzyl alcohol b. Methyl paraben c. Propylene glycol d. Chlorobutanol

C

Which of the following is NOT used in gas sterilization? a. Ethylene oxide b. Beta propiolactone c. Nitrogen d. Sulfur dioxide

C

Which of the following is NOT used in the formulation of shampoo? a. Lauric acid b. Triethanolamine c. Potassium carbonate d. Glycerin

C

Which of the following is frequently used as a staining dye in lipsticks? a. Carnauba wax b. Lanolin c. Eosine d. Castor oil

C

Which of the following statement is NOT true? a. Oxidation readily occurs in vegetable oils. b. Oxidation in emulsion produces rancidity. c. Oxidation produces emulsion with pleasant odor. d. BHA and BHT are most commonly used in cosmetics and pharmaceutical preparations.

C

Which type of glass is recommended for dry powders and oleaginous preparations but not for preparations with water. a. Type II b. NP c. Type III d. Type I

C

_______________ creams prevent skin melanogenesis. a. Shaving b. Hand c. Suntan d. Emollient

C

A functional requirement for Rubber Closures is a. It should be easily subjected to sterilization. b. It should not provide protection against bacterial contamination. c. It should not make bacteria-proof seals. d. It should provide complete barrier against vapor transport.

D

A process by which solids, liquids, or even gases may be enclosed in microscopic particles by formation of thin coatings of wall material around the substance is known as a. Complex Formation b. Microcompression c. Film Coating d. Microencapsulation

D

A satisfactory suppository base should pass the following criteria, EXCEPT: a. Should be nonsensitizing b. Should dissolve rapidly in the cavity fluid c. Should be firm d. Should remain solid at room temperature

D

An agent that acts between surfaces in relative motion to prevent friction and wear. a. Diluent b. Binder c. Disintegrant d. Lubricant

D

An element of the organization where types of work area are identified and grouped logically according to related elements is referred to as a. Determining duties of people b. Harmonious interrelationship among functions c. Delegation of authority d. Division of responsibility

D

An example of primary packaging material is a a. Insert b. Brochure c. Label d. Seal

D

An ideal preservative should be a. Nonreactive with microbes b. Available at all times c. Incorporated in small amounts only d. Effective against broad spectrum microbes

D

Cross contamination can come from the following, EXCEPT: a. Unclean clothing b. Airborne particles c. Improper dispensing d. Inaccuracies in mix-ups

D

Dispersion of high concentrations of insoluble powdered substances in a fatty or aqueous base a. Creams b. Lotions c. Ointment d. Pastes

D

Excess wetting agent may lead to the following I. Foaming II. Unpleasant taste III. Caking a. I and II b. II and III c. I and III d. I, II, III

D

Excessive use of binders in tablets affects a. Bioavailability b. Disintegration c. Dissolution d. AOTA

D

Film coating defect that refers to the presence of mottled areas on the film coat due to migration of plasticizers, dyes and other additives in the formulation. a. Mottling b. Blistering c. Spotting d. Bloom

D

Gel-based alcohol is an example of a/an a. Aqueous solution b. Non aqueous solution c. Emulsion d. Suspension

D

It implies a procedure by which decisions are made regarding whether the production is processing as planned. a. Master formula b. Control c. Sampling d. Monitoring

D

It is used as an opacifying agent and whitening pigment in the formulation of Face Powder. a. Talc b. Kaolin c. Zinc oxide d. Titanium dioxide

D

It is used as an opacifying agent in hard gelatin capsules. a. Triethanolamine b. Sorbitol c. Saccharin d. Titanium dioxide

D

It is used for compacting the materials in the tablet machine. a. Hopper b. Feed frame c. Dies d. Punches

D

Mechanism of action of radioactive isotopes for sterilization a. Coagulation of cellular proteins b. Oxidation c. Alkylation d. Lethal mutation

D

Metallic stearates are examples of a. Disintegrants b. Anti-adherents c. Binders d. Lubricants

D

Minimum permitted force for a satisfactory hard tablet. a. 2 kg b. 7 kg c. 3 kg d. 4kg e. 1 kg

D

Small, usually cylindrical, molded or compressed tablets containing small amounts of usually potent drugs are known as a. Dispensing tablets b. Chewable tablets c. Hypodermic tablets d. Tablet triturates

D

Solid dosage forms intended to pass through the stomach intact to disintegrate and release their drug content for absorption along the intestines are called a. Molded triturates b. Gelatin capsules c. Chewable tablets d. Enteric-coated tablets

D

Solubility maybe enhanced through a. Application of heat b. Agitation c. Reduction of particle size d. All of the above

D

Surfactants are compounds with hydrophobic and hydrophilic portion to the following, except a. Wetting b. Foaming c. Rinsability d. Viscosity

D

Tablet excipients that reduce interparticulate friction to ensure smooth and uniform flow of materials from larger through smaller apertures in tablet presses are called: a. Dusting agent b. Lubricant c. Anti-adherents d. Glidants

D

Test animal used in Pyrogen Test. a. Pigeon b. Swiss mice c. Guinea pig d. Rabbit e. Dog

D

The IPQC Test that determines the durability of a tablet and its ability to withstand abrasion in handling, packaging and shipment; USP requires a maximum weight loss of not more than 1% is the a. Tablet hardness b. Tablet disintegration c. Tablet thickness d. Friability test

D

The last step in the compounding procedure for liquid preparation prior to filling is a. Nitrogen flushing b. Volume adjustment c. Filtration d. Test for pH

D

The mesh size of regular lactose, USP a. 20-40 b. 40-60 c. 60-80 d. 80-100

D

The number of tablet samples which must be assayed for Content Uniformity according to USP a. 10 b. 15 c. 20 d. 30

D

The study of the deformation and flow of liquid and semi-solid preparations referred to as a. Emulsification b. Suspendability c. Compatibility study d. Rheology

D

Water, as a solvent in wet granulation a. Has the advantage of not being flammable b. Has the advantage of adversely affecting drug stability due to extended exposure to heat c. Requires less drying time than organic solvents d. Both a and b

D

What is the function of sorbic acid in the formulation of ointment? a. Ointment base b. Vehicle c. Active ingredient d. Preservative e. Flavorant

D

What is the therapeutic use of Zinc Oxide Paste? a. Protectant b. Antifungal c. Antiprupritec d. Analgesic e. Antiseptic

D

What is the use Purified Water, USP in the formulation of parenterals? a. Tonicity contributor b. Preservative c. Antioxidant d. Vehicle

D

What is the use of nitrogen in the formulation of parenterals? a. Buffer b. Tonicity contributor c. Preservative d. Antioxidant

D

What may happen to tablets if inadequate quantities of lubricants are used? a. Tablet produced may be harder to disintegrate. b. Tablets may be ejected too easily from the machine. c. Formed tablets may have oily spots. d. Formed tablets may have irregular striations on the edges.

D

Which of the following has to be considered in the formulation of emulsions? a. Consistency that will provide the desired stability and flow characteristics of emulsion must be attained. b. The use of preservative, since emulsion consist of a number of ingredients which support the growth of bacteria, molds, and yeast. c. Use of antioxidants. d. All of the above

D

Which of the following is NOT a torche? a. Strepsils b. Dequadin c. Valda Pastilles d. Dulcolax

D

Which of the following is NOT an example of sterile solution/preparation? a. Dialysis solution b. Pellets of implants c. Prefilled syringe d. Diagnostic solution

D

Which of the following is NOT true about the Pyrogen Test? a. It is designed to limit ta an acceptable level the risks of febrile reaction in the patient to the administration by injection of a product. b. Rabbit is used as test animal. c. No individual rabbit should show a rise in temperature by 0.6 degrees Celsius. d. The sum of the rise in temperature of 3 rabbits should not exceed 2.1 degrees Celsius

D

Which of the following is an example of animal secretion that is used in the formulation of fragrances? a. Benzoin b. Eugenol c. Myrrh d. Ambergris

D

Which of the following is the active component of toothpaste? a. Tawas b. Glycerin c. Hard soap d. Precipitated calcium carbonate

D

Which of the following is used as a lubricant in the formulation of Acetaminophen tablet? a. Lactose b. Corn starch c. Starch paste d. Magnesium stearate

D

Which of the following is used as a preservative in the formulation of parenterals? a. Sodium citrate b. Sodium EDTA c. Sodium chloride d. Methyl paraben

D

Which of the following is used as an antidandruff agent in the formulation of shampoos? a. Isopropyl alcohol b. Butyl alcohol c. Propylene alcohol d. Selenium sulfide

D

Which of the following is used as an antioxidant in the formulation of parenterals? a. Sodium chloride b. Sodium hydroxide c. Sodium citrate d. Sodium EDTA

D

Which of the following statement is NOT true? a. Oral aerosols are intended for administration as fine particles or as liquid mist via the respiratory system or nasal passages. b. The particle size of the active ingredient of aerosols must be considerably below 50 micrometers. c. Hydrocarbons have greater range of solubility than the fluorinated carbons. d. Compressed gases do not expand.

D

Which of the following statement is true? a. The backing layer of transdermal patches should be impermeable. b. None of the adhesive should stay on the peel strip. c. The adhesive must hold the drug securely in place. d. All of the above.

D

Yellow ointment is a hydrocarbon base. What is the synonym for yellow ointment? a. White petroleum jelly b. Yellow petrolatum c. Petroleum jelly d. Simple ointment e. Liquid petrolatum

D

_________ are substances that make up the major portion of tablet. a. Binder b. Glidant c. Lubricant d. Diluent e. Disintegrant

D

_________ is the removal of the edges of tablets. a. Capping b. Cracking c. Mottling d. Chipping e. Lamination

D

___________ increase the quality, volume, and stability of lather of shampoo. a. Conditioning agent b. Opacifying agent c. Clarifying agent d. Foam builder

D

_____________ help the tablet to dissolve once it is in an aqueous medium. a. Diluent b. Binder c. Colorant d. Disintegrant

D

_______________ are discoid shaped solid containing the medicinal agent in suitably flavored base. a. Capsules b. Powders c. Aerosols d. Troches

D

Commonly used lubricant in the formulation of tablets. a. Lactose b. Starch c. Mannitol d. Celutab e. Magnesium stearate

E

What is the smallest capsule size? a. 000 b. 00 c. 0 d. 1 e. 5

E

Which of the following is NOT used as a diluent in the formulation of a tablet? a. Celutab b. Corn starch c. Lactose d. Avicel e. Ethyl cellulose

E

Which of the following is NOT used as a diluent or absorbent in the formulation of capsules? a. Lactose b. Magnesium carbonate c. Kaolin d. Light magnesium Oxide e. Starch

E