MGY250 Unit 1 Quiz

Cancer is inherently Incurable A genetic disease An immune disorder A disease of the lymphatic system

A genetic disease

If you know the sequence of one strand of DNA, you can predict the sequence of the other strand because: The strands are anti-parallel One strand is arranged 5' —> 3' and the other strand is arranged 3' —> 5' Adenine always pairs with guanine and cytosine always pairs with thymine Adenine always pairs with thymine and cytosine always pairs with guanine

Adenine always pairs with thymine and cytosine always pairs with guanine

This speciality of medical genetics focuses on examining chromosomes and identifying chromosomal abnormalities: Laboratory biochemical genetics Clinical genetics Molecular genetics Cytogenetics Clinical biochemical genetics

Cytogenetics

Chromosomes are primarily composed of: Protein RNA Lipids DNA

DNA

Mendel is known as "the founder of genetics" because: His experiments established the rules of single gene inheritance with independent assortment He established the chromosomal theory of inheritance He was the first to recognize animalcules as the units of heredity He established the theory of preformation

His experiments established the rules of single gene inheritance with independent assortment

In the year 1900, the leading causes of death were: Non-communicable diseases, tuberculosis and pneumonia or influenza Infectious diseases, tuberculosis and pneumonia or influenza Non-communicable diseases, cancer and heart disease Infectious diseases, tuberculosis and cancer

Infectious diseases, tuberculosis and pneumonia or influenza

In the Canadian paediatric patient population: It is uncommon to find patients with genetic disorders, similar to the adult population It is uncommon to find patients with genetic disorders, unlike to the adult population It has been estimated that diseases where the dysfunction of a single gene is involved can account for up to 40% of the patient load

It has been estimated that diseases where the dysfunction of a single gene is involved can account for up to 40% of the patient load

Gleevec has been very successful in the treatment of chronic myeloid leukaemia because: It is a transplant of white blood cells It targets the mechanism of the cancer It indiscriminately kills fast growing cells It disables the immune system

It targets the mechanism of the cancer

This speciality of medical genetics is only about 25 years old and began with the ability to test DNA markers linked to disease genes. Clinical genetics Molecular genetics Clinical biochemical genetics Cytogenetics Laboratory biochemical genetics

Molecular genetics

Which of the following statements are true? Humans are considered complex organisms so naturally we have a greater amount of DNA than most other species The amount of DNA between individuals within a species is not relatively constant Organismal complexity is not related the amount of DNA The amount of DNA between species is not relatively constant

Organismal complexity is not related the amount of DNA The amount of DNA between species is not relatively constant

In Next Generation Illumina sequencing, what are the two purposes for the DNA tails added to the ends of the processed sample fragments? Provide a fluorescent signal to be captured by the imaging software Enable reverse transcription to take place when extracting RNA Ensure the library fragments are no longer than a few hundred base pairs Provide a binding site for the primers involved in the synthesis reaction Bind to flow cell oligos, capturing the sample libraries

Provide a binding site for the primers involved in the synthesis reaction Bind to flow cell oligos, capturing the sample libraries

Archibald Garrod determined that Mendel's laws of heredity could be applied to humans by: Performing experiments with humans that were similar to the experiments Mendel had performed with pea plants Genetic testing of members of a family afflicted by the same rare disease Searching all over Britain for people that shared the same rare symptoms Taking a family history of the members of a family that shared a rare disease

Taking a family history of the members of a family that shared a rare disease

Medical genetics can be defined as (select all that apply): The application of genetics to medicine or medical practice The study of the etiology, pathogenesis, and natural history of diseases and disorders that are at least partially genetic in origin The science of the human mind and its functions, especially those affecting behaviour in a given context The science of human biological variation as it relates to health and disease

The application of genetics to medicine or medical practice The study of the etiology, pathogenesis, and natural history of diseases and disorders that are at least partially genetic in origin The science of human biological variation as it relates to health and disease

Without telomere "caps" at the end of the chromosomes (select all that apply): The chromosome could degrade The chromosome may fuse with other broken chromosomes The chromosome may become involved in other recombination events

The chromosome could degrade The chromosome may fuse with other broken chromosomes The chromosome may become involved in other recombination events

The unique dark/light chromosomal staining patterns created by G-banding are due to: The nucleotide base pair composition and repetitive DNA elements The uncondensed state of stained DNA The age of the DNA The specific strand of DNA stained

The nucleotide base pair composition and repetitive DNA elements

The key ingredient for Sanger (dideoxy) sequencing is ddNTPs because: They synthesize the DNA resulting in fragments that differ in length by one nucleotide They are incorporated into DNA being synthesized, resulting in elongation of the DNA fragment They prevent further DNA synthesis, and when added at the appropriate ratio will result in DNA fragments that differ in length by one nucleotide They act as a primer, annealing to the starting DNA and allowing DNA polymerase to bind

They prevent further DNA synthesis, and when added at the appropriate ratio will result in DNA fragments that differ in length by one nucleotide

The two types of chromosomes are autosomes, X chromosomes autosomes, sex chromosomes X chromosomes, Y chromosomes autobots, sex chromosomes

autosomes, sex chromosomes

The gene TP53 provides instructions for the gene product p53, which is a tumour suppressor. Carriers of a constitutional (whole body) loss of function p53 allele (select all that apply): likely have Li-Fraumeni syndrome have increased survival following a comprehensive surveillance protocol have an increased lifetime risk of cancer

likely have Li-Fraumeni syndrome have increased survival following a comprehensive surveillance protocol have an increased lifetime risk of cancer

When not undergoing cell division, chromosomes are found in this state: polymorphic Arizona uncondensed condensed

uncondensed

Alleles are best defined as: the maternally inherited genes different genes on the same chromosome versions of the same gene that differ by their sequence of nucleotides the paternally inherited genes

versions of the same gene that differ by their sequence of nucleotides