Micro Quiz 5

Which of the influenza virus proteins binds to the host cell receptor? A. Hemaglutinin (HA) B. Neurraminidase (NA) C. Matrix (M1) D. Nucleocapsid (N) E. Ion channel (M2)

A

In the current classification scheme for viruses, all members of a virus family: A. Have the same animal host B. Have the same genome type C. Cause the same disease D. Have the same DNA sequence E. Are transmitted in the same manner

B

Integration of the viral genome into host cell chromosomal DNA is required for the replication cycles of which virus(es)? A. Influenza viruses B. Retroviruses C. Papillomaviruses D. All of the above E. None of the above

B

The retroviral TM (transmembrane) protein is responsible for: A. Binding of the virus to the host cell B. Fusion of the viral and host membranes C. Synthesis of viral DNA from the RNA genome D. Insertion of the provirus into the host cell chromosome E. Cleaves sugar residues off of the SU protein

B

Viruses can be classified based on all of the following EXCEPT: A. Arrangement of nucleic acid B. Cell wall structure C. Nucleic acid type D. Presence or absence of envelope E. Structure (shape)

B

Which of the following viruses has a segmented genome: A. HIV B. Influenza virus C. Papillomavirus D. All of the above E. None of the above

B

Another name for the protein coat of a virus is: A. Nonstructural protein B. Virion C. Structural protein D. Capsid E. Envelope

D

The Gardisil vaccine: A. Protects against infection with HIV B. Protects against infection with all influenza viruses C. Protects against infection with several types of human influenza viruses D. Protects against infection with 4 types of human papillomavirus E. Protects against infection with over 100 types of human papillomavirus

D

When purified virus is added to a dish of susceptible host cells, the first step in the virus replication cycle is: A. Synthesis of viral genomes B. Synthesis of viral proteins C. Fusion between the viral envelope and the host cell membrane D. Attachment of the virus to host cells via specific interactions E. The virus disassembles

D

Accumulation of point mutations in influenza virus HA and NA is commonly referred to as: A. Antigenic shift B. Antigenic drift C. Antigenic reassortment D. Antigen capture E. None of the above are correct

B

How/why do human papillomaviruses sometimes cause cancer? A. Infected cells are always killed B. Virus inhibits cell growth and division C. Virus promotes cell growth and division D. There are too many types for the immune system to recognize E. All of the above

C

Most of the antiretroviral drugs used to treat HIV target which step in the viral life cycle? A. Block virus binding to host cell B. Block virus penetration of virus into the cell C. Block reverse transcription D. Block integration E. Block assembly

C

The eclipse phase in the virus one-step growth curve can be defined or described as: A. Similar to the lag phase of bacterial growth B. The period before the virus has attached to the host cell C. A period where there are no infectious virus particles in the cells or in the culture D. The time it takes a virus to be transmitted from one host to another E. Similar to the log phase of bacterial growth

C

The host cell receptor for HIV is the CD4 molecule. Which statement is correct? A. CD4 is found on the surface of all human cells B. The only function for CD4 is to bind to HIV C. CD4 is found on the surface of some T cells, macrophages and dendritic cells D. CD4 is present on respiratory epithelial cells E. Answers A&B are correct

C

Which of the following proteins of the HIV virus is used to synthesize viral DNA? A. CA (capsid) B. MA (matrix) C. RT (reverse transcriptase) D. SU (surface) E. TM (transmembrane)

C

Which of the following statements accurately describes all viruses: A. All viral genomes are DNA B. Virus growth is exponential C. Virus particles are metabolically inactive D. Viruses use their own ribosomes for protein synthesis E. Viruses divide by binary fission

C

Influenza viruses use which of the following to replicate their genomes: A. Reverse transcriptase B. Hemagluttinin C. RNA-dependent DNA polymerase D. RNA-dependent RNA polymerase E. RNA-dependent RNA polymerase

E

The barriers to creating a safe and effective vaccine to protect against HIV infection include: A. Correlates of protection have NOT been determined B. Natural infection does NOT result in immunity C. There are many different genetic types of HIV (multiple clades) D. HIV mutation rate is high E. All of the above

E

The viral envelope is best described as a: A. Protein coat B. Genome C. Cell wall D. Peptidoglycan layer E. Lipid bilayer

E

Which of the following statements about viruses are TRUE? A. Cannot generate energy (ATP) or proteins outside of host cell B. All are obligate intracellular parasites C. Do not undergo cell division D. Are infectious agents E. All of the above

E