Pathophys Exam 2 Practice Questions

Which of the following is NOT a function of the lubricant in a tablet formulation? A) Improving flow properties of granules B) Reducing powder adhesion onto the dies and punches C) Improving tablet wetting in the stomach D) Reducing punch and die wear E) Facilitating tablet ejection from the die

C) Improving tablet wetting in the stomach

How is NuvaRing to be used? A) Worn around the wrist B) Only inserted into the vagina prior to intercourse C) Inserted into the vagina and left in for 21 days

C) Inserted into the vagina and left in for 21 days

The United States Pharmacopeia (USP) content uniformity test for tablets is used to ensure which of the following qualities? A) Bioequivalency B) Dissolution C) Potency D) Purity E) Toxicity

C) Potency

The rectal route of administration of drug may be preferred over the oral route for some systemic-action because A) the drug does not have to be absorbed B) absorption is predictable and complete C) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation D) inert binders, diluents, and excipients cannot interfere with absorption E) the dissolution process is avoided.

C) a portion of the absorbed drug does not pass through the liver before entering the systemic circulation

United States Pharmacopeia (USP) tests for ensuring the quality of drug products in tablet form include all of the following EXCEPT. A) disintegration B) dissolution C) hardness and friability D) content uniformity E) weight variation

C) hardness and friability

Tablet formulation problem #1 If the API of 125 mg tablet decays by zero-order kinetics with a reaction rate constant kinetic of 0.5 mg per hour, what is the amount of intact drug remaining after 3 days (72 hours)? A. 0.89 mg B. 8.9 mg C. 89 mg D. 890 mg

C. 89 mg

What is the active form of Nepafenac? A. Diclofenac B. Ibuprofen C. Amfenac D. NAC (acetylcysteine)

C. Amfenac

Which of the following capsules sizes has the largest capacity? A) 5 B) 4 C) 1 D) 0 E) 000

E) 000

Most commercial vaginal suppositories use a base of A) Beewax B) Cocoa butter C) Glycerin D) glycerinated gelatin E) Polyethylene glycols

E) Polyethylene glycols

13. Which two ingredients serve as both glidants and anti-adherent agents? A. talc and magnesium stearate B. polyethylene glycol and titanium dioxide C. microcrystalline cellulose and Lactose monohydrate D. croscarmellose sodium and providone (PVP)

A. talc and magnesium stearate

Hypromellose 2208 is an ingredient in all Glucophage XR tablets. If this ingredient was removed from the medication what can we expect to change in the therapeutic effect or manufacturing process of Glucophage XR? A. Product would stick to machinery when being manufactured, causing an array of issues. B. The release of glucophage XR when taken would be less controlled and result in a quicker release of the drug, removing the benefit of being an ER tablet C. Product may cake and will struggle to freely flow during manufacturing. D. No therapeutic or manufacturing effect will be noticed.

B. The release of glucophage XR when taken would be less controlled and result in a quicker release of the drug, removing the benefit of being an ER tablet

What is the role of propylene glycol in Imvexxy? A.) Plasticizer B.) Lubricant C.) Preservative D.) Suppository Base

C.) Preservative

Which of the following is not a coating agent used for Rilutek? Hypromellose (HPMC) Polyethylene Glycol 6000 Hypromellose Phtalate (HPMCP) Titanium Dioxide

Hypromellose Phtalate (HPMCP)

Agents that might be used to coat enteric-coated tablets include: I. hydroxypropyl methylcellulose (HPMC) II. carboxymethylcellulose (CMC) III. cellulose acetate phtalate (CAP)

III. cellulose acetate phtalate (CAP)

Which of the following statements is not true about Methylin (methylphenidate HCl)? It is a central nervous system stimulant. It stimulates the reuptake of norepinephrine and dopamine. It is used for the treatment of Attention Deficit and Hyperactivity Disorder (ADHD). Maltose and aspartame are two ingredients that act as sweeteners. It is classified as "class I" in regards to the Biopharmaceutics Classification System.

It stimulates the reuptake of norepinephrine and dopamine.

Which of the following is the active ingredient of Methylin? Methylphenidate HCl Aspartame Microcrystalline Cellulose AandC All of the Above

Methylphenidate HCl

Starch is the main disintegrant ingredient in the Decadron tablet formulation. The primary purpose of starch is to: Promote particle aggregation/cohesion in liquid state Prevent sticking to die and punch Facilitate flow of granules from hopper Promote break down of particle aggregates

Promote break down of particle aggregates

Which flavoring is used in the ODT tablet? Mint Orange Strawberry Ghost Pepper Attack Helicopter

Strawberry

Which of the following is not an available formulation for Norvir? Tablet Soft gelatin capsules Solution Suspension

Suspension

SELECT/MATCH the most likely reason for the condition 10. Picking 11. Mottling 12. Capping 13. Sticking A) Excessive moisture in the granulation B) Entrapment of air C) Tablet friability D) Degraded drug E) Tablet hardness

10-A. Picking 11-D. Mottling 12-B. Capping 13-A. Sticking

Match the following: 14) Drug is bound to a resin and released due to changes in pH 2 15) Drug is compressed into tablets with a slowly soluble polymer 16) Drug is compressed into tablets with an insoluble polymer 17) Drug is compressed into tablets with semipermeable membrane and a laser drilled hole through which drug is transported out by convective flow. A) Encapsulated dissolution B) Ion-exchange C) Matrix diffusion D) Matrix dissolution E) Osmotic pumping

14 B 15 D 16 C 17 E

Under what temperature conditions should Indocin suppositories be stored? 2°C to 8°C (36°F to 46°F) 8°C to 14°C (46°F to 57°F) 0°C to 6°C (32°F to 42°F) Below 0°C (32°F)

2°C to 8°C (36°F to 46°F)

The shells of soft gelatin capsules may be made elastic or plastic-like by the addition of A) sorbitol B) povidone C) polyethylene glycol (PEG) D) lactose E) hydroxypropyl methylcellulose (HPMC)

A) sorbitol

Dose dumping is a problem in the formulation of A) compressed tablets B) modified-release drug products C) hard gelatin capsules D) soft gelatin capsules E) suppositories

B) modified-release drug products

What is a reason why rectal suppository formulation of an NSAID would be preferred for a patient? Rectal suppositories offer less therapeutic response than other formulations Patient is unconscious Patient is alert, aware, and able to swallow pills or capsules Patient is experiencing nausea/vomiting Both B and D

Both B and D

Viral transduction enanchers are materials used to increase the amount of gene expression in the target tissue. Which of the following ingredients assists in gene transduction efficiency? A. Sodium phosphate dibasic B. Sodium chloride C. Poloxamer 188 D. Sodium phosphate monobasic

C. Poloxamer 188

Capsule formulation problem A pharmacist receives a prescription for 15 mg piroxicam capsules, qty. 48. A #1 capsule filled with piroxicam weighs 245 mg; a capsule filled with lactose weighs 180 mg. How much piroxicam and lactose are required for the prescription? Prepare sufficient powder for 50 capsules (2 extra). A. 15 mg piroxicam + 165 mg lactose B. 750 mg piroxicam + 9.00 g lactose C. 750 mg piroxicam + 8.45g lactose D. 15 mg piroxicam + 230 mg lactose E. None of the above

C?

In which solubility class can you find Norvir? Class I Class II Class III Class IV

Class IV

Tablet formulation problem #2 Considering this "secret" formula and procedure, the amount of Acetaminophen (in kg) required to produce 1 million Tylenol tablets is A) 0.5 kg B) 5 kg C) 50 kg D) 500 kg E) 500,000 kg

D) 500 kg

Which one of the following statements concerning tablet dissolution is NOT true? A) Disintegration precedes dissolution B) In vivo disintegration is usually a good predictor of dissolution C) Changing a drug's crystalline state may change dissolution rates D) Increasing tablet compression force will increase dissolution E) Micronization of drug powder will decrease dissolution time

D) Increasing tablet compression force will increase dissolution

A satisfactory suppository base must meet all of the following criteria EXCEPT A) it should have a narrow melting range B) it should be nonirritating and nonsensitizing C) it should dissolve or disintegrate rapidly in the body cavity D) it should melt below 30 degrees C E) it should be inert

D) it should melt below 30 degrees C

A sweetener that is widely employed in chewable tablet formula is: A) aspartame B) glucose C) lactose D) mannitol E) sucrose

D) mannitol

If a bottle has an expiration date of Dec 2021 on it, the pharmacist can use it until: A) up to 1 year after the expiration date B) only through January 31, 2021 C) only through December 15, 2021 D) only through December 31, 2021 E) if the pharmacist informs the patient to discard unused tablets in 6 months

D) only through December 31, 2021

What does Luxturna use as a vector to carry a functional gene into the affected eye tissue? A. Poxvirus B. Adenovirus C. Retrovirus D. Adeno-associated virus

D. Adeno-associated virus

What is a disadvantage with using direct compression method? A. Fewer steps B. Direct compression excipients possess inherent disintegration properties (microcrystallinecellulose) C. Faster dissolution compared to wet granulation D. Occurrence of unblending due to variability in API and excipients

D. Occurrence of unblending due to variability in API and excipients

Which of the following is true about the storage conditions of DSUVIA? DSUVIA should be stored at 30 degrees celsius DSUVIA should be stored away from light DSUVIA can be stored in a bathroom cabinet Because light only affects color, it does not matter if DSUVIA is protected from light

DSUVIA should be stored away from light

True statements, about the function of excipients used in tablet formulations include: I. Binders promote granulation during the wet granulation process II. Glidants help to promote the flow of the tablet granulation during the manufacture III. Lubricants help the patient to swallow the tablets.

I. Binders promote granulation during the wet granulation process II. Glidants help to promote the flow of the tablet granulation during the manufacture

Advantages to the manufacturer for tablet film coating when compared to sugar coating include: I. shorter production times II. less gross weight III. lower incidence in coat chipping

I. shorter production times II. less gross weight III. lower incidence in coat chipping

.The prime purpose for which of the following types of coating may be to mask the bitter taste of an orally administered drug? I. Enteric II. Film III. Sugar

II. Film III. Sugar

As described in Case Study 1, Decadron is a conventional release tablet. Given that Decadron follows first-order releases kinetics, it can be assumed: The rate of drug release is independent of time and constant over time The rate of drug release is delayed for a predefined period of time The rate of drug release declines exponentially with time The rate of drug release increases exponentially

The rate of drug release declines exponentially with time

Which of the following is not an ingredient(s) in ibuprofen: a. Maltose b. Lactose c. Croscarmellose sodium d. Colloidal silicon dioxide e. hot butter f. A and E

f. A and E

Formulation of Motrin involves: low shearing mixing pre-formed ingredients wet mixtures explosions none of the above

none of the above