practice questions pharm 2
A drug-induced lupus-like syndrome is associated with this antihypertensive drug A) minoxidil (Loniten) B) hydralazine (Apresoline) C) diazoxide (Hyperstat) D). nitroprusside sodium (Nipride) E) acebutolol (Sectral)
B
(True/False) Heart rate X Stroke Volume = cardiac output A) true B) false
A
(True/False) Increased preload usually leads to increased contractility: A) true B) false
A
Cardioselective beta-blockers bind to this receptor subtype: A) beta1 B) beta2
A
True/False) Cardiac Output X Peripheral Resistance = Arterial Pressure A) true B) false
A
Administration of anesthesia to patients treated with antihypertensive drugs A) increased likelihood of orthostatic hypotension B) reduced systemic blood-pressure responses to acute blood loss C) reduced systemic blood-pressure responses to body position changes D) altered physiological response to sympathomimetic drugs
A & D
Neurogenic causes of systolic and diastolic hypertension: (more than one answer) A) polyneuritis B) elevated intracranial pressure C) familial dysautonomia D) polyarteritis nodosa E) pheochromocytoma
A, B, C
A diabetic patient is prescribed a new medication to control mild hypertension. The patient then becomes less aware of hypoglycemic symptoms. The antihypertensive drug was most probably: A) phentolamine (Regitine) B) atenolol (Tenormin) C) enalapril (Vasotec) and D) hydralazine (Apresoline) E) prazosin (Minipress)
B
Antihypertensive agents -- side effect profile includes impaired glucose tolerance, hypokalemia, increased serum lipids and increased renin secretion: A) methyldopa (Aldomet) B) chlorothiazide (Diuril) C) nifedipine (Procardia, Adalat) D) nitroprusside sodium (Nipride) E) diazoxide (Hyperstat)
B
Antihypertensive drug least likely to cause orthostatic hypotension: A minoxidil (Loniten) B enalapril (Vasotec) C guanethidine (Ismelin) D hydralazine (Apresoline) E terazosin (Hytrin)
B
Effect of concurrent administration of nonsteroidal anti-inflammatory agents on antihypertensive properties of beta-blockers: A) enhanced antihypertensive effect B) diminished antihypertensive effect C) no effect
B
Effect on renin levels of beta adrenergic receptor blockers: A) increased B) decreased
B
Effects of hydralazine (Apresoline): A) increased renin levels B) lupus-like syndrome C) reflex bradycardia D) hypertensive response if patient ingests food rich in tyramine E) all of the above
B
Principal thiazide site of action: A) late distal tubule and collecting duct B) distal convoluted tubule C) loop of Henle
B
Possible antihypertensive effects: (more than one answer) A) increased peripheral resistance B) decreased afterload C) increased preload D) decrease contractility E) all of the above
B & D
Examples of selective beta1 adrenergic receptor blockers: (more than one answer) A) propranolol (Inderal) B) metoprolol (Lopressor) C) atenolol (Tenormin) D) acebutalol E) albuterol (Ventolin,Proventil)
B, C, &D
Antihypertensive drug typically used in patients with severe hypertension and renal insufficiency; this agent produces significant fluid retention and hypertrichosis. A) hydralazine (Apresoline) B) methyldopa (Aldomet) C) minoxidil (Loniten) D) nitroprusside sodium (Nipride) E) diltiazem (Cardiazem)
C
Maintenance of antihypertensive drug treatment during the perioperative period A) Previously effective antihypertensive drug therapy should be continued during the perioperative phase B) The pharmacology of the particular antihypertensive drug should be considered in the development of the anesthesia plan C) Both of the above
C
Selective blockers of alpha1 adrenergic receptors: A) propranolol (Inderal) B) phentolamine (Regitine) C) prazosin (Minipress) D) atropine E) neostigmine (Prostigmin)
C
Tachycardia due to hydralazine administration would be blocked by: A) bumetanide (Bumex) B) fosinopril (Monopril) C) mecamylamine (Inversine) D) nifedipine (Procardia, Adalat) E) minoxidil (Loniten)
C
Vascular smooth muscle relaxation by means of calcium channel blockade: A hydralazine (Apresoline) B nitroprusside sodium (Nipride) C nifedipine (Procardia, Adalat) D captopril (Capoten) E phentolamine (Regitine)
C
(more than one answer) Major classes of diuretics used in hypertension management: A) loop diuretics B) osmotic diuretics C) potassium sparing diuretics D) thiazides E) carbonic anhydrase inhibitor's
C & D
Antihypertensive agent that can produce a positive Coombs' test A clonidine (Catapres) B guanabenz (Wytensin) C guanfacine (Tenex) D methyldopa (Aldomet) E all the above
D
Hypertension of unknown etiology-- causes: A) toxemia of pregnancy B) acute intermittent porphyria C) essential hypertension D) All of the above
D
The drug of choice in management of hypertensive crisis when continuously variable IV infusion is required. A) lisinopril (Prinvivil, Zestril) B) diazoxide (Hyperstat) C) nifedipine (Procardia, Adalat) D) nitroprusside sodium (Nipride) E) metoprolol (Lopressor)
D
This antihypertensive drug is contraindicated in patients with bilateral renal artery stenosis: A clonidine (Catapres) B terazosin (Hytrin) C nifedipine (Procardia, Adalat) D captopril (Capoten) E metoprolol (Lopressor)
D
Which drug would be least likely used in the initial pharmacological treatment of mild hypertension? A) amlodipine (Norvasc) B) metoprolol (Lopressor) C) enalapril (Vasotec) D) minoxidil (Loniten) E) chlorothiazide (Diuril)
D
Lisinopril belongs to which class of antihypertensive drugs? A) centrally-acting sympatholytic B) beta-adrenoceptor antagonist C) angiotensin II receptor antagonist D) beta-adrenoceptor agonist E) angiotensin II converting enzyme inhibitor
E
Mechanisms by which blood-pressure may be reduced: A) reduced cardiac output B) increased vagus nerve activity C) decreased central sympathetic outflow D) reduced angiotensin II levels E) all the above
E
More likely to cause bronchospasm and mask hypoglycemia: A) metoprolol (Lopressor) B) atenolol (Tenormin) C) timolol (Blocadren) D) pindolol (Visken) E) C & D
E
Orthostatic hypotension: A minoxidil (Loniten) B imipramine (Tofranil) C hydralazine (Apresoline) D methyldopa (Aldomet) E all of the above
E
Adverse effects associated with beta-adrenergic receptor blockers: A) bradycardia B) bronchospasm C) masking of hypoglycemia D) impotence E) sedation F) All of the above
F
Antihypertensive drugs classified as "adrenergic neuron blockers": A) clonidine (Catapres) B) guanethidine (Ismelin) C) guanadrel (Hylorel) and D) reserpine E) guanabenz (Wytensin) F) B, C, D
F
