WBC Morphology, Structure, and Function

A

A distinguishing unique morphological characteristic of monocytes, is which of the following? A. indented, folded, and clefted nucleus B. Cytoplasmic granules C. Cytoplasmic basophilia D. A single large nucleus with nucleoli

D

About 1/3 of the cytoplasmic granules in a neutrophil are what kind of granules? A. Eosinophilic B. Neutrophil-specific C. Basophilic D. Azurophilic

A

Activated lysosomal granules of neutrophil become attached to the phagosome and empty their hydrolytic enzymes into the phagosome, killing and dissolving their contents. This is a process known as _________ A. Degranulation B. Chemotaxis C. Phagocytosis D. Granulopoiesis

B

All of the following are characteristics of a myeloblast, EXCEPT: A. No cytoplasmic granules B. Low N/C ratio C. Uniform chromatin pattern D. 2-5 nucleoli

B

All of the following are eosinophilic functions EXCEPT: A. Neutralization of histamine B. Produce IL-2 C. Defense against subcutaneous parasitic infections D. Phagocytosis

B

All of the following are true about the monocyte/macrophage, EXCEPT: A. they have phagocytic activity B. Heparin containing granules C. they secrete IL_1 D. can destroy old RBCs

A

All of the following nucleated cells can routinely be found on a normal Wright's stained blood smear, EXCEPT: A. Megakaryocyte B. Segmented neutrophil C. Monocyte D. Lymphocyte

B

All of the following stages of neutrophil maturation make up the mitotic compartment, EXCEPT: A. promyelocyte B. metamyelocyte C. myeloblast D. myelocyte

A

At a given speed, decreasing the angle of the spreader slide will result in what kind of slide? A. A longer, thinner smear B. A shorter, thicker smear C. A slide with too much basophilia D. A thicker, acidophilic slide``

A

Basophil degranulation is connected with which of the following immunoglobulins? A. IgE B. IgM C. IgG D. IgA

C

Chronic granulomatous disease (CGD) is a disease due to a deficient enzyme called _________, and the most common clinical presentation is susceptibility to _________. A. myeloperoxidase, viral infection B. amine oxidase, severe allergic reaction C. NADPH oxidase, bacterial infection D. Acid muramidase, parasite infection

B

Classify the type of WBC seen on the blood smear image below. A. Lymphocyte B. Monocyte C. Immature granulocyte D. Macrophage

B

Complement C3b and C5a are involved in an inflammation reaction by playing the role of ________. A. Growth factor B. Chemotactic factor C. Iron sequestering agent D. Monocyte inhibition factor

D

General characteristics of cell aging from youngest to oldest cell stage include all of the following, EXCEPT: A. High N/C ratio --> Low N/C ratio B. Nucleoli present --> Nucleoli absent C. Finer chromatin pattern --> Coarser more dense pattern D. Small cell size --> large cell size

D

Identify the 4th cell from the left A. promyelocyte B. myeloblast C. Band neutrophil D. metamyelocyte

C

Identify the WBC in the blood smear image below. A. Eosinophil B. Lymphocyte C. Basophil D. Myeloblast

B

Identify the first cell from the left A. promyelocyte B. Blast C. metamyelocyte D. band neutrophils

B

Identify the white blood cell shown below: A. Lymph B. Segmented neutrophil C. Band neutrophil D. Eosinophil

C

If a blood smear stains RBCs bright red upon microscopic examination of a Wright's stained preparation, possible causes include: A. The staining time was too long B. The buffer was too basic C. The buffer was too acidic, or the staining time(exposure with the buffer) was too short. D. Inadequate washing

D

In the attached image, identify the WBC A. blast B. myelocyte C. basophil D. promyelocyte

C

In the figure below you see a blood smear with 4 white blood cells. Cell "C" is an example of a (an): A. Eosinophil B. Segmented neutrophil C. Basophil D. Monocyte

C

In the process of neutrophil maturation, _____ is the last stage capable of mitosis A. blast B. promyelocyte C. myelocyte D. metamyelocyte

C

In this slide of a blood smear there are four WBCs. Which of the following white blood cells is NOT found on the blood smear image? A. Segmented neutrophil B. Lymphocyte C. Eosinophil D. Monocyte

B

Monocytes can enter tissues and be transformed into: A. Plasma cells B. Macrophages C. Histocytes D. B-Lymphocytes

A

Monocytes/macrophages secrete_______ which is an activator for many immune cells such as T and B lymphocytes, neutrophils and macrophages. A. IL-1 B. IL-3 C. Interferon D. TNF

B

Neutrophils bind to bacteria through A. CD4 receptors B. Immunoglobulin FC and C3 receptors C. Chemotactic factors D. CD8 receptors

A

Poor blood smears can be caused by all of the following factors, EXCEPT: A. Holding the spreader slide at a 45 degree angle B. Holding the spreader slide at 10 degree angle C. A drop of blood that is too large or too small D. Pushing forward the spreader slide too fast

B

Regarding the WBC in the image below, which of the following is the immature progenitor of this cell that is capable of mitosis? A. monoblast B. myelocyte C. metamyelocyte D. promonocyte

B

The 3 white cells in the attached image is most likely A. promyelocytes B. blasts C. myelocytes D. bands

A

The blood for this slide was obtained from a 70 year old woman with a history of anemia and low WBC count, malaise, mild weight loss, and easy bruising. Identify the WBC in the blood smear image below. A. Myeloblast B. Lymphocyte C. Myelocyte D. Monocyte

D

The blood smear image below was taken from the blood of a 28 year old woman with splenomegaly. What cell is indicated by the arrow? A. Monocyte B. Metamyelocyte C. Myeloblast D. Myelocyte

D

The cell indicated by the arrow in the blood smear image below is an example of a: A. Lymphocyte B. Band Neutrophil C. Megakaryocyte D. Monocyte

B

The cell shown in this slide is a band neutrophil. If this patient showed a significant increase of these cells on this blood smear, this patient could be reported to have a: A. Routine typical blood smear B. A shift to the left C. Thrombocytosis D. A shift to the right

C

The cells pointed by arrows are A. Promyelocyte B. Myelocyte C. Macrophages D. Monocytes

A

The granules of the WBC are known to contain all of the following substances, EXCEPT: A. myeloperoxidase B. Histamine C. SRS-A D. Heparin

A

The leukocyte normally found in the circulation with the lowest absolute concentration is: A. Basophil B. Eosinophil C. Monocyte D. Myeloblast

A

The leukocyte shown in this image is a typical example of a: A. Band neutrophil B. Lymphocyte C. Basophil D. Monocyte

C

The two WBCs in the picture below are A. monocytes B. neutrophils C. lymphocytes D. eosinophils

A

There are three white blood cells shown on this blood smear image below. The one in the middle is A. Band B. Eosinophil C. Basophil D. Lymphocyte

A

What is the cell pointed by the green arrow? A. Myeloblast B. Metamyelocyte C. Myelocyte D. Segmented neutrophil

B

What is the cell pointed by the red arrow? A. Segmented neutrophil B. Metamyelocyte C. Myelocyte D. Myeloblast

B

When making a blood smear a drop of well mixed whole blood is placed about 1 cm from the end of the slide. A second slide is held and placed against the surface of the 1st slide, just in front of the drop of blood. Ideally, this second "spreader slide" should be placed at what angle to the bottom slide with the drop of blood? A. 15* B. 45* C. 70* D. 90*

C

Which enzyme is involved in the O2 dependent pathway of bacterial killing by the neutrophil? A. Pyruvate kinase B. Hydrogen peroxide C. Myeloperoxidase D. Oxygenase

B

Which maturation stage has the most pronounced cytoplasmic basophilia? A. Promyelocyte B. Myeloblast C. Myelocyte D. Metamyelocyte

C

Which of the following correctly describe the morphological change when the WBCs develop from immature to mature cells? A. cytoplasmic basophilia gets darker B. cell size gets larger C. nuclear chromatin gets coarser D. N:C ratio gets greater

C

Which of the following correctly describes the morphological change when the WBCs develop from immature to mature cells. A. N/C ratio: from small to big B. Nuclear chromatin: from coarse to fine C. Cytoplasm staining: dark blue to pink D. Nuclear shape: from irregular to regular

D

Which of the following factors can affect the blood film quality and/or the staining quality? A. Angle of spreader slide B. pH of stain or buffer C. Staining and washing times D. All of the above

B

White cells are stimulated to migrate toward sites of inflammation by: A. Blood flow B. Chemotactic substances C. Continual production of new cells D. Neural stimulus

B

__________ stimulates regeneration, maturation, and differentiation of multipotential and unipotential stem cells. A. IL-1 B. IL-3 C. GM-CSF D. TNF

B

_____________ stimulates neutrophil, eosinophil, and monocyte growth A. G-CSF B. GM-CSF C. IL-3 D. M-CSF