Adaptive Immune Function

For a----- killer T cell (TC) to become activated, it must recognize a foreign peptide complexed with self MHC-I and mount a direct attack upon the target cell.

CD4

The MHC-II antigen on the APC binds to the helper T-cell receptor first followed by a coreceptor on the helper T cell called ----- typically hooks itself to a position on the MHC-II receptor.

CD4

Generates many B cells and T cells that are activated against specific antigens: Antigen expression Antigen presentation Opsonization Antibody production Clonal expansion

Clonal expansion

Lymphocyte maturation involves: All of the choices are correct. B cells maturing in bone marrow sites. release of mature lymphocytes to begin migration to various lymphoid organs. T cells maturing in the thymus. hormonal signals that initiate development.

All of the choices are correct.

Antigen presenting cells: include dendritic cells include macrophages engulf and modify antigen to be more immunogenic hold and present processed antigen on their cell membrane surface All of the statements are correct

All of the statements are correct

Acquired specific immunity involves the response of: interferon skin barriers lysozyme B and T lymphocytes mucus membranes

B and T lymphocytes

Humoral immunity involves B cells , while T cells function in cell-mediated immunity.

B cells T cells

Match the following Matures in the bone marrow Matures in the Thymus Secretes cytokines and aids the response of both B cells and T cells Professional antigen presenting cell

B-cell T cell Helper T cell Dendritic cells

Which of the following would be affected when T helper cells are destroyed in HIV infections? Select all that apply. humoral immunity first line of defense second line of defense third line of defense cell mediated immunity

humoral immunity third line of defense cell mediated immunity

Specific immunity provides long-lasting protection through the production of: memory cells T helper cells antibodies phagocytotic cells plasma cells

memory cells

Which lymphocyte secretes antibodies in a specific immune response? memory B cells T cytotoxic cells T helper cells plasma cells

plasma cells

Plasma cells: function in allergic reactions.​ secrete antibodies. directly destroy target cells. activate B cells and other T cells. suppress immune reactions.

secrete antibodies.

Small foreign molecules that are too small by themselves to elicit an immune response are termed: antigen binding sites. epitopes. variable regions. haptens.

Haptens

The immunoglobulin class that has a dimer form found in mucus, saliva, colostrum, and other body secretions is: IgD IgG IgM IgA IgE

IgA

The immunoglobulin class that is the only one capable of crossing the placenta is: IgM IgD IgG IgE IgA

IgG

A patient was never exposed nor vaccinated against chickenpox. A couple days ago the patient was exposed, and the patient currently has chicken pox virus. Which antibody would you expect to have the highest titer based on this exposure? IgA IgD IgG IgE IgM

IgM

------- is a pentamer and is the first antibody produced at exposure to an antigen.------ is a dimer and is found in body secretions. ---- is the most prevalent immunoglobulin in the body. IgE is produced as part of the inflammatory response

IgM IgA IgG IgE

The antibody-secreting progeny cells of a B-cell clone are called: sensitized T cells. antibodies. bursa cells. plasma cells. activated macrophages.

Plasma cells

MHC molecules are found on all cells except: leukocytes. epithelial cells. eosinophils. red blood cells. islet of Langerhans cells.

RBC

An example of artificial active immunity would be a vaccination. True False

True

The cells of the adaptive immune system are educated to distinguish your cells from invading pathogens, cells that would respond to self-antigens are destroyed in immune tolerance. This property of adaptive immunity is attributed to the Unresponsiveness to self Clonality Inducibility Memory Specificity

Unresponsiveness to self

A foreign molecule that causes a specific immune response is a(n): PAMP antibody marker hapten antigen

antigen

T helper cells play a pivotal role in generating antibodies humoral immunity only cell-mediated immunity only both cell-mediated and humoral immunity

both cell-mediated and humoral immunity

Two months later, the same patient is then exposed to chicken pox virus again. Which immunoglobulin will be present in the highest amount after this new exposure? IgA IgM IgE IgD IgG

IgG

Specific immunity provides long-lasting protection through the production of: T helper cells plasma cells phagocytotic cells memory cells antibodies

Memory cells

A fetus acquiring maternal IgG to the chickenpox virus across the placenta. Chickenpox vaccine triggering extended immunity to chickenpox. Chickenpox infection followed by lifelong immunity. Giving a person immune globulins to chickenpox virus after exposure to the virus.

Natural passive immunity Articial active immunity Natural active immunity Artificial passive immunity

T cells mature in the bone marrow? True False

fasle

B-cells are part of----------- and T cells are part of------

humoral immunity cell-mediated immunity

Cytotoxic T cells: secrete interleukin-2 to stimulate B and T cells. are activated by free, soluble antigens. secrete granzymes and perforins that damage target cells. lack specificity for antigen.

secrete granzymes and perforins that damage target cells.

Properties of effective antigens include all of the following except: they are cells or large, complex molecules they are large polymers made up of repeating subunits they are large molecules with a minimum molecular weight of 1,000 they have molecular complexity they are foreign to the immune system

they are large polymers made up of repeating subunits